Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Jason M. Gow"'
Autor:
Stephanie E Hesselson, Pär Matsson, James E Shima, Hisayo Fukushima, Sook Wah Yee, Yuya Kobayashi, Jason M Gow, Connie Ha, Benjamin Ma, Annie Poon, Susan J Johns, Doug Stryke, Richard A Castro, Harunobu Tahara, Ji Ha Choi, Ligong Chen, Nicolas Picard, Elin Sjödin, Maarke J E Roelofs, Thomas E Ferrin, Richard Myers, Deanna L Kroetz, Pui-Yan Kwok, Kathleen M Giacomini
Publikováno v:
PLoS ONE, Vol 4, Iss 9, p e6942 (2009)
Membrane transporters play crucial roles in the cellular uptake and efflux of an array of small molecules including nutrients, environmental toxins, and many clinically used drugs. We hypothesized that common genetic variation in the proximal promote
Externí odkaz:
https://doaj.org/article/09fb7e921026438cb6a8f93630163930
Autor:
Sabina Buntich, Amber Umble-Romero, Wei-Jian Pan, L Som, Jason M. Gow, C D Krill, Yu Sun, Samantha P. Prokop, Kathleen Köck, Alexander Colbert, Yu Zhang, Wayne Tsuji, Jennifer E. Towne, T J Goletz, M W Trimble, William A. Rees, John P. Gibbs, Michelle Horner, J C O'Neill, Kathryn J. Newhall
Publikováno v:
British Journal of Pharmacology. 172:159-172
Background and Purpose AMG 139 is a human anti-IL-23 antibody currently in a phase II trial for treating Crohn's disease. To support its clinical development in humans, in vitro assays and in vivo studies were conducted in cynomolgus monkeys to deter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff2df1ca4f60b9725b1651875f7c7b2d
https://doi.org/10.1111/bph.12904
https://doi.org/10.1111/bph.12904
Autor:
Anthony M. Treacy, Virginia M Platt, Christine M. Evangelista, Dominic C. Borie, Lynn Smith, Mark Yen, Jane M. Andrews, Peter J. Prince, Kefei Zhou, Wei-Jian Pan, Christine D Krill, Graham L. Radford-Smith, Jason M. Gow, Kaz O Reynhardt, Jonathan Lee, Zhigang Yu, David R. Doherty, Kathleen Köck, William A. Rees, Barbara A. Sullivan, Sonal K. Patel, Jing Jing Shen
Publikováno v:
British Journal of Clinical Pharmacology. 78:1315-1333
AIMS AMG 181 pharmacokinetics/pharmacodynamics (PK/PD), safety, tolerability and effects after single subcutaneous (s.c.) or intravenous (i.v.) administration were evaluated in a randomized, double-blind, placebo-controlled study. METHODS Healthy mal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b4affc6406b420c1a3ccb1e05e144e99
https://doi.org/10.1111/bcp.12418
https://doi.org/10.1111/bcp.12418
Autor:
M Habashian, Jason M. Gow, Mary V. Relling, Deanna L. Kroetz, Mark J. Ratain, Wanqing Liu, R. M. Baldwin, Svetlana Markova, Tan D. Nguyen
Publikováno v:
The pharmacogenomics journal
Multidrug resistance protein 2 (MRP2, ABCC2) is an efflux membrane transporter highly expressed in liver, kidney and intestine with important physiological and pharmacological roles. The goal of this study was to investigate the functional significan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c895673cc72e736c5209e85850e33337
https://doi.org/10.1038/tpj.2012.20
https://doi.org/10.1038/tpj.2012.20
Autor:
Jason M. Gow, Russ B. Altman, Deanna L. Kroetz, Svetlana Markova, Leslie W. Chinn, Laura M. Hodges, Teri E. Klein
Publikováno v:
Pharmacogenetics and Genomics. 21:152-161
ABCB1 descriptionABCB1 (MDR1) is one of many ubiquitous adenosine triphosphate (ATP)-binding cassette (ABC) genes present in all kingdoms of life that is responsible for cellular homeostasis [1–3]. ABC genes encode transporter and channel proteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80a3f5a3db1135f96342e81caaf0c9a6
https://doi.org/10.1097/fpc.0b013e3283385a1c
https://doi.org/10.1097/fpc.0b013e3283385a1c
Autor:
Andrej Sali, Rachel Karchin, Jason M. Gow, Ursula Pieper, Deanna L. Kroetz, Leslie W. Chinn, Libusha Kelly, Hisayo Fukushima, Mark R. Segal
Publikováno v:
Protein Science. 19:2110-2121
The human ATP-binding cassette (ABC) transporter superfamily consists of 48 integral membrane proteins that couple the action of ATP binding and hydrolysis to the transport of diverse substrates across cellular membranes. Defects in 18 transporters h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5393982390e6b40f755bea7bfc257bb0
https://doi.org/10.1002/pro.491
https://doi.org/10.1002/pro.491
Publikováno v:
Journal of Antimicrobial Chemotherapy. 60:61-67
Objectives: ABCB1 encodes the efflux transporter P-glycoprotein (P-gp), which regulates the intracellular concentration of many xenobiotics, including several HIV protease inhibitors (PIs). Exposure to some xenobiotics, such as the antibiotic rifampi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16fe6e9ed87b2d29576d16fab838295e
https://doi.org/10.1093/jac/dkm135
https://doi.org/10.1093/jac/dkm135
Autor:
Shawn L. Searle, David Sciberras, Tim Mant, Wayne Tsuji, John P. Gibbs, Gary J. Williams, Jason M. Gow, Daniel T. Mytych
Publikováno v:
Arthritis Research & Therapy
Introduction Nerve growth factor plays a key role in the pathology of osteoarthritis (OA) related chronic pain. The aim of these studies was to evaluate the safety, tolerability, pharmacokinetics, and clinical response of AMG 403, a human anti-nerve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61348242f30081da075f299745d3db05
http://europepmc.org/articles/PMC4599327
http://europepmc.org/articles/PMC4599327
Autor:
Laura M, Hodges, Svetlana M, Markova, Leslie W, Chinn, Jason M, Gow, Deanna L, Kroetz, Teri E, Klein, Russ B, Altman
Publikováno v:
Pharmacogenetics and genomics. 21(3)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a071e3399b09c81cc5825d961bf4a0a5
https://pubmed.ncbi.nlm.nih.gov/20216335
https://pubmed.ncbi.nlm.nih.gov/20216335
Autor:
Yuya Kobayashi, Benjamin Ma, Deanna L. Kroetz, Maarke J.E. Roelofs, Sook Wah Yee, Ji Ha Choi, Stephanie Hesselson, Ligong Chen, Connie Ha, Hisayo Fukushima, Pui-Yan Kwok, Harunobu Tahara, Kathleen M. Giacomini, Pär Matsson, Richard M. Myers, Nicolas Picard, James E. Shima, Doug Stryke, Susan J. Johns, Elin Sjödin, Annie Poon, Jason M. Gow, Richard A. Castro, Thomas E. Ferrin
Publikováno v:
PloS one, vol 4, iss 9
PLoS ONE, Vol 4, Iss 9, p e6942 (2009)
PLoS ONE
PLoS ONE, Vol 4, Iss 9, p e6942 (2009)
PLoS ONE
Membrane transporters play crucial roles in the cellular uptake and efflux of an array of small molecules including nutrients, environmental toxins, and many clinically used drugs. We hypothesized that common genetic variation in the proximal promote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3d723da0a968f5281896b4ddea40a7a
https://escholarship.org/uc/item/1m1186zr
https://escholarship.org/uc/item/1m1186zr
