Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Jason M. Christie"'
Autor:
Owen Y. Chao, Salil Saurav Pathak, Hao Zhang, George J. Augustine, Jason M. Christie, Chikako Kikuchi, Hiroki Taniguchi, Yi-Mei Yang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Social recognition memory (SRM) is a key determinant of social interactions. While the cerebellum emerges as an important region for social behavior, how cerebellar activity affects social functions remains unclear. We selectively increased
Externí odkaz:
https://doaj.org/article/89225d647d484f2ba0478a41bfaab34a
Autor:
Audrey Bonnan, Matthew M. J. Rowan, Christopher A. Baker, M. McLean Bolton, Jason M. Christie
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Plastic reweighting of parallel fiber synaptic strength is a mechanism for the acquisition of cerebellum-dependent motor learning. Here, the authors found that optogenetic activation of PCs generates dendritic Ca2+ signals that induce plasticity in v
Externí odkaz:
https://doaj.org/article/231e3ecfe8014b23afce4d2cc0b1ebd2
Autor:
Diego Jerez, Eleanor Stuart, Kylie Schmitt, Debbie Guerrero-Given, Jason M. Christie, Naomi Kamasawa, Michael S. Smirnov
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Electron microscopy (EM) enables high-resolution visualization of protein distributions in biological tissues. For detection, gold nanoparticles are typically used as an electron-dense marker for immunohistochemically labeled proteins. Manua
Externí odkaz:
https://doaj.org/article/5a0c7fe657b7450eb58edf43c22c8435
Publikováno v:
eLife, Vol 11 (2022)
The cerebellum is hypothesized to represent timing information important for organizing salient motor events during periodically performed discontinuous movements. To provide functional evidence validating this idea, we measured and manipulated Purki
Externí odkaz:
https://doaj.org/article/8b4f057b358447fe8cb8643939ea62df
Publikováno v:
The Journal of Neuroscience. 43:601-612
Procedural memories formed in the cerebellum in response to motor errors depend on changes to Purkinje cell (PC) spiking patterns that correct movement when the erroneous context is repeated. Because molecular layer interneurons (MLIs) inhibit PCs, l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::619317e9485867da4ec656ccc17aa883
https://doi.org/10.1523/jneurosci.0731-22.2022
https://doi.org/10.1523/jneurosci.0731-22.2022
Autor:
Diego Jerez, Eleanor Stuart, Kylie Schmitt, Debbie Guerrero-Given, Jason M. Christie, William E. Hahn, Naomi Kamasawa, Michael S. Smirnov
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/50c57fe7bfa44c1e896241192b383768
Autor:
Matthew J.M. Rowan, Jason M. Christie
Publikováno v:
Cell Reports, Vol 18, Iss 8, Pp 2018-2029 (2017)
In many neurons, subthreshold depolarization in the soma can transiently increase action-potential (AP)-evoked neurotransmission via analog-to-digital facilitation. The mechanisms underlying this form of short-term synaptic plasticity are unclear, in
Externí odkaz:
https://doaj.org/article/8fe5d63206b141459e2151a710ab52b7
Publikováno v:
J Neurosci
Duchenne muscular dystrophy (DMD), the most common form of childhood muscular dystrophy, is caused by mutations in the dystrophin gene. In addition to debilitating muscle degeneration, patients display a range of cognitive deficits thought to result
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddf3daf4e6eb736a7adf7f6f05f23daa
https://doi.org/10.1523/jneurosci.1256-21.2022
https://doi.org/10.1523/jneurosci.1256-21.2022
Publikováno v:
eLife, Vol 7 (2018)
Motor learning involves neural circuit modifications in the cerebellar cortex, likely through re-weighting of parallel fiber inputs onto Purkinje cells (PCs). Climbing fibers instruct these synaptic modifications when they excite PCs in conjunction w
Externí odkaz:
https://doaj.org/article/f939885e8b6644f88526190d9d3d688c
Autor:
Samantha B Amat, Matthew J M Rowan, Michael A Gaffield, Audrey Bonnan, Chikako Kikuchi, Hiroki Taniguchi, Jason M Christie
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0179347 (2017)
The cerebellar system helps modulate and fine-tune motor action. Purkinje cells (PCs) provide the sole output of the cerebellar cortex, therefore, any cerebellar involvement in motor activity must be driven by changes in PC firing rates. Several diff
Externí odkaz:
https://doaj.org/article/5a5971fc0bb9471b9ba326a726830076