Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Jason M Tennessen"'
Autor:
Sophie A Fleck, Puja Biswas, Emily D DeWitt, Rebecca L Knuteson, Robert C Eisman, Travis Nemkov, Angelo D'Alessandro, Jason M Tennessen, Elizabeth Rideout, Lesley N Weaver
Publikováno v:
eLife, Vol 12 (2024)
The ease of genetic manipulation in Drosophila melanogaster using the Gal4/UAS system has been beneficial in addressing key biological questions. Current modifications of this methodology to temporally induce transgene expression require temperature
Externí odkaz:
https://doaj.org/article/22a6cb8f6cb04786abf01b646a597a0f
Publikováno v:
PLoS ONE, Vol 19, Iss 1, p e0287865 (2024)
Drosophila melanogaster larval development relies on a specialized metabolic state that utilizes carbohydrates and other dietary nutrients to promote rapid growth. One unique feature of the larval metabolic program is that Lactate Dehydrogenase (Ldh)
Externí odkaz:
https://doaj.org/article/d4d58fe9eab74a379ad378dfcf6aa701
miR-125-chinmo pathway regulates dietary restriction-dependent enhancement of lifespan in Drosophila
Autor:
Manish Pandey, Sakshi Bansal, Sudipta Bar, Amit Kumar Yadav, Nicholas S Sokol, Jason M Tennessen, Pankaj Kapahi, Geetanjali Chawla
Publikováno v:
eLife, Vol 10 (2021)
Dietary restriction (DR) extends healthy lifespan in diverse species. Age and nutrient-related changes in the abundance of microRNAs (miRNAs) and their processing factors have been linked to organismal longevity. However, the mechanisms by which they
Externí odkaz:
https://doaj.org/article/89e6fb71bceb40c682285f5113659ac7
Autor:
Simranjot Bawa, David S Brooks, Kathryn E Neville, Marla Tipping, Md Abdul Sagar, Joseph A Kollhoff, Geetanjali Chawla, Brian V Geisbrecht, Jason M Tennessen, Kevin W Eliceiri, Erika R Geisbrecht
Publikováno v:
eLife, Vol 9 (2020)
Cell growth and/or proliferation may require the reprogramming of metabolic pathways, whereby a switch from oxidative to glycolytic metabolism diverts glycolytic intermediates towards anabolic pathways. Herein, we identify a novel role for TRIM32 in
Externí odkaz:
https://doaj.org/article/b8f7ff5e057c440da2bb12f20db8fda5
Autor:
Gabriela Krejčová, Adéla Danielová, Pavla Nedbalová, Michalina Kazek, Lukáš Strych, Geetanjali Chawla, Jason M Tennessen, Jaroslava Lieskovská, Marek Jindra, Tomáš Doležal, Adam Bajgar
Publikováno v:
eLife, Vol 8 (2019)
Macrophage-mediated phagocytosis and cytokine production represent the front lines of resistance to bacterial invaders. A key feature of this pro-inflammatory response in mammals is the complex remodeling of cellular metabolism towards aerobic glycol
Externí odkaz:
https://doaj.org/article/988c82f9ff7246d7af99d3165741a2d1
Autor:
Nader H. Mahmoudzadeh, Yasaman Heidarian, Jason P. Tourigny, Alexander J. Fitt, Katherine Beebe, Hongde Li, Arthur Luhur, Kasun Buddika, Liam Mungcal, Anirban Kundu, Robert A. Policastro, Garrett J. Brinkley, Gabriel E. Zentner, Travis Nemkov, Robert Pepin, Geetanjali Chawla, Sunil Sudarshan, Aylin R. Rodan, Angelo D'Alessandro, Jason M. Tennessen
Publikováno v:
Molecular Metabolism, Vol 89, Iss , Pp 102013- (2024)
Objectives: The mitochondrial enzyme L-2-hydroxyglutarate dehydrogenase (L2HGDH) regulates the abundance of L-2-hydroxyglutarate (L-2HG), a potent signaling metabolite capable of influencing chromatin architecture, mitochondrial metabolism, and cell
Externí odkaz:
https://doaj.org/article/c959551a1a6c44d4a4238d794febab0c
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e78913 (2013)
To search for evolutionary forces that might act upon transcript length, we use the singular value decomposition (SVD) to identify the length distribution functions of sets and subsets of human and yeast transcripts from profiles of mRNA abundance le
Externí odkaz:
https://doaj.org/article/02d52f15baf149b187e18ffa51c4e7f1
Autor:
François Busquet, Jeanne Laperrouze, Katica Jankovic, Tamara Krsmanovic, Tomasz Ignasiak, Benedetta Leoni, Gordana Apic, Giovanni Asole, Roderic Guigó, Paolo Marangio, Emilio Palumbo, Silvia Perez-Lluch, Valentin Wucher, Anna Hendrika Vlot, Robert Anholt, Trudy Mackay, Beate I. Escher, Nico Grasse, Julia Huchthausen, Riccardo Massei, Thorsten Reemtsma, Stefan Scholz, Gerrit Schüürmann, Maria Bondesson, Peter Cherbas, Jonathan H. Freedman, Stephen Glaholt, Jessica Holsopple, Stephen C. Jacobson, Thomas Kaufman, Ellen Popodi, Joseph J. Shaw, Shannon Smoot, Jason M. Tennessen, Gary Churchill, Christina Cramer von Clausbruch, Thomas Dickmeis, Gaëlle Hayot, Giuseppina Pace, Ravindra Peravali, Carsten Weiss, Nadezda Cistjakova, Xin Liu, Andis Slaitas, James (Ben) Brown, Rafael Ayerbe, Joan Cabellos, Elena Cerro-Gálvez, María Diez-Ortiz, Verónica González, Rubén Martínez, Patricia Solórzano Vives, Rosemary Barnett, Thomas Lawson, Robert G. Lee, Elena Sostare, Mark Viant, Roland Grafström, Vesa Hongisto, Pekka Kohonen, Konrad Patyra, Pradeep Kumar Bhaskar, Marcial Garmendia-Cedillos, Ibraheem Farooq, Brian Oliver, Tom Pohida, Ghadi Salem, Daniel Jacobson, Elisabeth Andrews, Marianne Barnard, Aleksandra Čavoški, Anurag Chaturvedi, John K. Colbourne, David J.T. Epps, Laura Holden, Martin R. Jones, Xiaojing Li, Ferenc Müller, Agata Ormanin-Lewandowska, Luisa Orsini, Ruth Roberts, Ralf J.M. Weber, Jiarui Zhou, Mu-En Chung, Juan Carlos Gonzalez Sanchez, Gaurav D. Diwan, Gurdeep Singh, Uwe Strähle, Robert B. Russell, Dominique Batista, Susanna-Assunta Sansone, Philippe Rocca-Serra, David Du Pasquier, Gregory Lemkine, Barbara Robin-Duchesne, Andrew Tindall
The goal of PrecisionTox is to overcome conceptual barriers to replacing traditional mammalian chemical safety testing by accelerating the discovery of evolutionarily conserved toxicity pathways that are shared by descent among humans and more distan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::876b7659dcbf87711644cfc5deccdefc
https://ora.ox.ac.uk/objects/uuid:bed21c1b-b26c-4b6d-aea0-dce1e848c810
https://ora.ox.ac.uk/objects/uuid:bed21c1b-b26c-4b6d-aea0-dce1e848c810
Autor:
Sen Yang, Zhen-Xian Niou, Andrea Enriquez, Jacob LaMar, Jui-Yen Huang, Karen Ling, Paymaan Jafar-Nejad, Jonathan Gilley, Michael P. Coleman, Jason M. Tennessen, Vidhya Rangaraju, Hui-Chen Lu
Background Bioenergetic maladaptations and axonopathy are often found in the early stages of neurodegeneration. Nicotinamide adenine dinucleotide (NAD), an essential cofactor for energy metabolism, is mainly synthesized by Nicotinamide mononucleotide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::834e9326976cca119528a0fea2b3b836
https://doi.org/10.21203/rs.3.rs-2859584/v1
https://doi.org/10.21203/rs.3.rs-2859584/v1
Obesity is increasing worldwide, particularly in rural communities, where people are likely exposed to high levels of pesticides. We here investigated whether six commonly used agricultural pesticides on corn and soy fields have adipogenic activity a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::51f07ba0478ae59819862f3835339cf9
https://doi.org/10.1101/2023.04.14.536563
https://doi.org/10.1101/2023.04.14.536563