Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Jason M Spaeth"'
Autor:
Rebecca K Davidson, Staci A Weaver, Nolan Casey, Sukrati Kanojia, Elise Hogarth, Rebecca Schneider Aguirre, Emily K Sims, Carmella Evans-Molina, Jason M Spaeth
Publikováno v:
J Mol Endocrinol
Type 2 diabetes (T2D) is associated with loss of transcription factors (TFs) from a subset of failing β-cells. Among these TFs is Pdx1, which controls the expression of numerous genes involved in maintaining β-cell function and identity. Pdx1 activ
Autor:
Rebecca K. Davidson, Sukrati Kanojia, Wenting Wu, Tatsuyoshi Kono, Jerry Xu, Meredith Osmulski, Robert N. Bone, Nolan Casey, Carmella Evans-Molina, Emily K. Sims, Jason M. Spaeth
The transcriptional activity of Pdx1 is modulated by a diverse array of coregulatory factors that govern chromatin accessibility, histone modifications, and nucleosome distribution. We previously identified the Chd4 subunit of the nucleosome remodeli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a03ae668fe75f1bb64d63f350f20ed1
https://doi.org/10.2337/figshare.22236679
https://doi.org/10.2337/figshare.22236679
Autor:
Jason M. Spaeth, Sangeeta Dhawan
Publikováno v:
Diabetes. 71:1614-1616
Autor:
Mikko Turunen, Jason M. Spaeth, Salla Keskitalo, Min Ju Park, Teemu Kivioja, Alison D. Clark, Netta Mäkinen, Fangjian Gao, Kimmo Palin, Helka Nurkkala, Anna Vähärautio, Mervi Aavikko, Kati Kämpjärvi, Pia Vahteristo, Chongwoo A. Kim, Lauri A. Aaltonen, Markku Varjosalo, Jussi Taipale, Thomas G. Boyer
Publikováno v:
Cell Reports, Vol 7, Iss 3, Pp 654-660 (2014)
Somatic mutations in exon 2 of the RNA polymerase II transcriptional Mediator subunit MED12 occur at very high frequency (∼70%) in uterine leiomyomas. However, the influence of these mutations on Mediator function and the molecular basis for their
Externí odkaz:
https://doaj.org/article/59206a3393054e17a8c174a02fdf6b30
Publikováno v:
Diabetes. 70
A key feature of type 1 and type 2 diabetes is insufficient functional β-cell mass. Strategies to augment functional β-cell mass include directed differentiation of embryonic stem cells towards a β-cell fate, which requires extensive knowledge of
Publikováno v:
Diabetes. 70
Diabetes progression is partly characterized by a loss of key transcription factors (TFs) in a subset of failing β-cells. Among these TFs is Pdx1, which coordinates the expression of numerous genes related to β-cell function (MafA, Ins2, Ucn3), mit
Publikováno v:
Diabetes. 70
Pancreatic β-cells are crucial for glucose-stimulated insulin secretion (GSIS) and whole-body glucose homeostasis. Dysfunctional β-cell mass results in diabetes mellitus (DM), a growing pandemic causing global economic burden. Pancreas-enriched tra
Publikováno v:
Endocrinology
Islet β-cell dysfunction that leads to impaired insulin secretion is a principal source of pathology of diabetes. In type 2 diabetes, this breakdown in β-cell health is associated with compromised islet-enriched transcription factor (TF) activity t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9abe64b99fad33f68306d47fca1c5b40
https://europepmc.org/articles/PMC7749714/
https://europepmc.org/articles/PMC7749714/
Autor:
Roland Stein, Mark Perelis, Joseph Bass, Holly A. Cyphert, Shuangli Guo, Yu-Ping Yang, Jin Hua Liu, Mark A. Magnuson, Christopher V.E. Wright, Jason M. Spaeth, Min Guo, Manisha Gupte
Publikováno v:
Diabetes. 66:2830-2839
The transcription factor encoded by the Pdx1 gene is a critical transcriptional regulator, as it has fundamental actions in the formation of all pancreatic cell types, islet β-cell development, and adult islet β-cell function. Transgenic- and cell
Autor:
Christopher V.E. Wright, Anil Bhushan, Fardin Mohammadi, Anna B. Osipovich, Nilotpal Roy, Daniel Peters, Jason M. Spaeth, Matthias Hebrok, Jin Hua Liu, Mark A. Magnuson, Min Guo, Roland Stein
Publikováno v:
Diabetes, vol 68, iss 9
Diabetes
Diabetes
Transcription factors positively and/or negatively impact gene expression by recruiting coregulatory factors, which interact through protein-protein binding. Here we demonstrate that mouse pancreas size and islet β-cell function are controlled by th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::178b8790efc4dc093bdcaf8fb08bdf0c
https://escholarship.org/uc/item/2ks8d4pt
https://escholarship.org/uc/item/2ks8d4pt