Výsledky vyhledávání - "Jason M Sheltzer"

Akademický článek

Micronuclei-based model system reveals functional consequences of chromothripsis in human cells

Autor: Maja Kneissig, Kristina Keuper, Mirjam S de Pagter, Markus J van Roosmalen, Jana Martin, Hannah Otto, Verena Passerini, Aline Campos Sparr, Ivo Renkens, Fenna Kropveld, Anand Vasudevan, Jason M Sheltzer, Wigard P Kloosterman, Zuzana Storchova

Publikováno v: eLife, Vol 8 (2019)

Cancer cells often harbor chromosomes in abnormal numbers and with aberrant structure. The consequences of these chromosomal aberrations are difficult to study in cancer, and therefore several model systems have been developed in recent years. We sho

Externí odkaz: https://doaj.org/article/574814c022834ba19e0b5bb4d7e9d020

Zobrazit plný text záznamu

Akademický článek

Systematic identification of mutations and copy number alterations associated with cancer patient prognosis

Autor: Joan C Smith, Jason M Sheltzer

Publikováno v: eLife, Vol 7 (2018)

Successful treatment decisions in cancer depend on the accurate assessment of patient risk. To improve our understanding of the molecular alterations that underlie deadly malignancies, we analyzed the genomic profiles of 17,879 tumors from patients w

Externí odkaz: https://doaj.org/article/2315081caf4744e08fd706862f704cbf

Zobrazit plný text záznamu

Akademický článek

An elevated rate of whole-genome duplications in cancers from Black patients

Autor: Leanne M. Brown, Ryan A. Hagenson, Tilen Koklič, Iztok Urbančič, Lu Qiao, Janez Strancar, Jason M. Sheltzer

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)

Abstract In the United States, Black individuals have higher rates of cancer mortality than any other racial group. Here, we examine chromosome copy number changes in cancers from more than 1800 self-reported Black patients. We find that tumors from

Externí odkaz: https://doaj.org/article/e4e2e07b9fa94f0899002c6acd2dcdb7

Zobrazit plný text záznamu

Akademický článek

MELK expression correlates with tumor mitotic activity but is not required for cancer growth

Autor: Christopher J Giuliano, Ann Lin, Joan C Smith, Ann C Palladino, Jason M Sheltzer

Publikováno v: eLife, Vol 7 (2018)

The Maternal Embryonic Leucine Zipper Kinase (MELK) has been identified as a promising therapeutic target in multiple cancer types. MELK over-expression is associated with aggressive disease, and MELK has been implicated in numerous cancer-related pr

Externí odkaz: https://doaj.org/article/74b1625563b9473ca17e33fb23458412

Zobrazit plný text záznamu

Akademický článek

CRISPR/Cas9 mutagenesis invalidates a putative cancer dependency targeted in on-going clinical trials

Autor: Ann Lin, Christopher J Giuliano, Nicole M Sayles, Jason M Sheltzer

Publikováno v: eLife, Vol 6 (2017)

The Maternal Embryonic Leucine Zipper Kinase (MELK) has been reported to be a genetic dependency in several cancer types. MELK RNAi and small-molecule inhibitors of MELK block the proliferation of various cancer cell lines, and MELK knockdown has bee

Externí odkaz: https://doaj.org/article/b99d40db238a4793959d3b76a7669da3

Zobrazit plný text záznamu

Akademický článek

Evolving copy number gains promote tumor expansion and bolster mutational diversification

Autor: Zicheng Wang, Yunong Xia, Lauren Mills, Athanasios N. Nikolakopoulos, Nicole Maeser, Scott M. Dehm, Jason M. Sheltzer, Ruping Sun

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)

Abstract The timing and fitness effect of somatic copy number alterations (SCNA) in cancer evolution remains poorly understood. Here we present a framework to determine the timing of a clonal SCNA that encompasses multiple gains. This involves calcul

Externí odkaz: https://doaj.org/article/a2aa4e2c332c42c18d976ced25f4b625

Zobrazit plný text záznamu

Extensive protein dosage compensation in aneuploid human cancers

Autor: Klaske M. Schukken, Jason M. Sheltzer

Publikováno v: Genome Research. 32:1254-1270

Aneuploidy is a hallmark of human cancers, but the effects of aneuploidy on protein expression remain poorly understood. To uncover how chromosome copy number changes influence the cancer proteome, we conducted an analysis of hundreds of human cancer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cadec73cdf74bad69a09631d544819c0
https://doi.org/10.1101/gr.276378.121

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání