Zobrazeno 1 - 10
of 110
pro vyhledávání: '"Jason M Butler"'
Autor:
Ana G Freire, Jason M Butler
Publikováno v:
F1000Research, Vol 9 (2020)
The generation of hematopoietic stem cells (HSCs) from pluripotent stem cell (PSC) sources is a long-standing goal that will require a comprehensive understanding of the molecular and cellular factors that determine HSC fate during embryogenesis. A p
Externí odkaz:
https://doaj.org/article/e3db11d4df5d41d5bb65a492dea6256e
Autor:
Bi-Sen Ding, Daylon James, Rajiv Iyer, Ilaria Falciatori, Dolores Hambardzumyan, Su Wang, Jason M Butler, Sina Y Rabbany, Adília Hormigo
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e62150 (2013)
In glioblastoma high expression of the CD133 gene, also called Prominin1, is associated with poor prognosis. The PDGF-driven proneural group represents a subset of glioblastoma in which CD133 is not overexpressed. Interestingly, this particular subse
Externí odkaz:
https://doaj.org/article/ac63ba960db24b3f91ee1746ded443f1
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e26918 (2011)
The mechanism by which hematopoietic stem and progenitor cells (HSPCs) through interaction with their niches maintain and reconstitute adult hematopoietic cells is unknown. To functionally and genetically track localization of HSPCs with their niches
Externí odkaz:
https://doaj.org/article/1dfe41be9b7241728c67243cbda7e35f
Autor:
Pradeep Ramalingam, Michael C. Gutkin, Michael G. Poulos, Taylor Tillery, Chelsea Doughty, Agatha Winiarski, Ana G. Freire, Shahin Rafii, David Redmond, Jason M. Butler
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Aging associated defects within stem cell-supportive niches contribute towards age-related decline in stem cell activity. However, mechanisms underlying age-related niche defects, and whether restoring niche function can improve stem cell fi
Externí odkaz:
https://doaj.org/article/bfeb0e9c16e84018b805b3d540fe3b9c
Autor:
Pradeep Ramalingam, Michael G. Poulos, Elisa Lazzari, Michael C. Gutkin, David Lopez, Christopher C. Kloss, Michael J. Crowley, Lizabeth Katsnelson, Ana G. Freire, Matthew B. Greenblatt, Christopher Y. Park, Jason M. Butler
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
Myelosuppressive injuries lead to chronic MAPK activation and impair blood reconstitution. Here, the authors show that chronic activation endothelial MAPK impairs hematopoietic stem cell (HSC) function through NFkB signaling, and that post-myelosuppr
Externí odkaz:
https://doaj.org/article/6b54770221c34086b376c539aef6277a
Autor:
Michael G. Poulos, Pradeep Ramalingam, Michael C. Gutkin, Maria Kleppe, Michael Ginsberg, Michael J. P. Crowley, Olivier Elemento, Ross L. Levine, Shahin Rafii, Jan Kitajewski, Matthew B. Greenblatt, Jae-Hyuck Shim, Jason M. Butler
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
The complex microenvironmental signalling pathways that govern haematopoietic stem cell (HSC) activity remain poorly defined. Here, the authors identify endothelial NF-κB signalling as regulating regenerative HSC function, accelerating haematopoieti
Externí odkaz:
https://doaj.org/article/95743d5eec914dfda2ea75f85a602491
Autor:
Brandon Hadland, Barbara Varnum-Finney, Stacey Dozono, Tessa Dignum, Cynthia Nourigat-McKay, Adam M. Heck, Takashi Ishida, Dana L. Jackson, Tomer Itkin, Jason M. Butler, Shahin Rafii, Cole Trapnell, Irwin D. Bernstein
Publikováno v:
Nature Communications. 13
Hematopoietic stem cells (HSCs) develop from hemogenic endothelium within embryonic arterial vessels such as the aorta of the aorta-gonad-mesonephros region (AGM). To identify the signals responsible for HSC formation, here we use single cell RNA-seq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd419a9a0b73f4774ad4c7d4e228b4a4
https://doi.org/10.1038/s41467-022-28781-z
https://doi.org/10.1038/s41467-022-28781-z
Autor:
Michael G. Poulos, Peipei Guo, Natalie M. Kofler, Sandra Pinho, Michael C. Gutkin, Anastasia Tikhonova, Iannis Aifantis, Paul S. Frenette, Jan Kitajewski, Shahin Rafii, Jason M. Butler
Publikováno v:
Cell Reports, Vol 4, Iss 5, Pp 1022-1034 (2013)
The bone marrow (BM) microenvironment is composed of multiple niche cells that, by producing paracrine factors, maintain and regenerate the hematopoietic stem cell (HSC) pool (Morrison and Spradling, 2008). We have previously demonstrated that endoth
Externí odkaz:
https://doaj.org/article/a2de7d96b8d94890af4dc12d7b19d166
Autor:
Mahmoud Dabbah, Aditya Barve, Emilia Kooienga, Zakiya Kelley, Jason M Butler, Marta Derecka, Shannon McKinney-Freeman
Publikováno v:
Blood. 140:8622-8622
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ea8f35a649f1ef5149804da8ed43227
https://doi.org/10.1182/blood-2022-164738
https://doi.org/10.1182/blood-2022-164738
Publikováno v:
Blood. 140:8623-8623
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb0842ae97c7a93b5135427df2e14332
https://doi.org/10.1182/blood-2022-167869
https://doi.org/10.1182/blood-2022-167869