Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Jason M Brouwer"'
Autor:
Rachel T Uren, Martin O’Hely, Sweta Iyer, Ray Bartolo, Melissa X Shi, Jason M Brouwer, Amber E Alsop, Grant Dewson, Ruth M Kluck
Publikováno v:
eLife, Vol 6 (2017)
During apoptosis, Bak and Bax undergo major conformational change and form symmetric dimers that coalesce to perforate the mitochondrial outer membrane via an unknown mechanism. We have employed cysteine labelling and linkage analysis to the full len
Externí odkaz:
https://doaj.org/article/48645ef9a7cc4f43a59462f285e8cf9b
Autor:
Mark F. van Delft, Meng Xiao Luo, Kate McArthur, Peter E. Czabotar, Jarrod J. Sandow, Laura F. Dagley, Kym N Lowes, Jason M. Brouwer, Andrew I. Webb, Guillaume Lessene, Rachael M. Lane, Keith G. Watson, Christoph Grohmann, Ahmad Wardak, Peter M. Colman, Sabrina Bernard, Soo San Wan, Yelena Khakham, Phillip P. Sharp, Romina Lessene, Thao Nguyen, David J. Segal, David C.S. Huang, Erinna F. Lee, Lucy Li, Marlyse A. Debrincat, Grant Dewson, Chinh T. Bui, Hui San Chin, W. Douglas Fairlie, Stephane Duflocq, Benjamin T. Kile, Stephane Chappaz, Caroline Miles, Kurt Lackovic, Laure Peilleron
Publikováno v:
Nature Chemical Biology. 15:1057-1066
Activating the intrinsic apoptosis pathway with small molecules is now a clinically validated approach to cancer therapy. In contrast, blocking apoptosis to prevent the death of healthy cells in disease settings has not been achieved. Caspases have b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::21f8a84e9d19f8763b3963c4941664e3
https://doi.org/10.1038/s41589-019-0365-8
https://doi.org/10.1038/s41589-019-0365-8
Autor:
Yepy H Rustam, Iris K. L. Tan, Eugene A. Kapp, Jonathan P. Bernardini, Grant Dewson, Peter M. Colman, Nicholas A. Smith, Jarrod J. Sandow, Jason M. Brouwer, M.J. Roy, Andrew I. Webb, Gavin E. Reid, Brian J. Smith, Peter E. Czabotar, Angus D. Cowan, Jacqueline M. Gulbis, James M. Murphy, Ahmad Wardak
Publikováno v:
Nature structuralmolecular biology. 27(11)
BAK and BAX are essential mediators of apoptosis that oligomerize in response to death cues, thereby causing permeabilization of the mitochondrial outer membrane. Their transition from quiescent monomers to pore-forming oligomers involves a well-char
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d09b3adc9911ffb81c34d497964c1f7
https://pubmed.ncbi.nlm.nih.gov/32929280
https://pubmed.ncbi.nlm.nih.gov/32929280
Autor:
Iris K. L. Tan, Shuai Huang, Grant Dewson, Jonathan P. Bernardini, Christopher D. Riffkin, Jason M. Brouwer, Michael Lazarou, Peter E. Czabotar, Aleksandra Bankovacki, Che A. Stafford, Ahmad Wardak, Jarrod J. Sandow
Publikováno v:
The EMBO Journal. 38
The E3 ubiquitin ligase Parkin is a key effector of the removal of damaged mitochondria by mitophagy. Parkin determines cell fate in response to mitochondrial damage, with its loss promoting early onset Parkinson's disease and potentially also cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::013040f5b0dd73734e6da83d43a23de2
https://doi.org/10.15252/embj.201899916
https://doi.org/10.15252/embj.201899916
Autor:
Peter M. Colman, Jason M. Brouwer, Grant Dewson, Cindy S. Luo, Richard W Birkinshaw, Ruth M. Kluck, Sweta Iyer, Michelle S. Miller, Adeline Y. Robin, Rachel T Uren, Peter E. Czabotar, Daisy Lio
Publikováno v:
Molecular Cell. 81:2123-2134.e5
A body of data supports the existence of core (α2-α5) dimers of BAK and BAX in the oligomeric, membrane-perturbing conformation of these essential apoptotic effector molecules. Molecular structures for these dimers have only been captured for trunc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b729c755b41c79fe3f8a589e452c32a9
https://doi.org/10.1016/j.molcel.2021.03.014
https://doi.org/10.1016/j.molcel.2021.03.014
Autor:
Adeline Y. Robin, Rachel T Uren, Grant Dewson, D. Westphal, Peter E. Czabotar, Peter M. Colman, Geoff V. Thompson, Ruth M. Kluck, Ray Bartolo, Jason M. Brouwer
Publikováno v:
Molecular Cell. 55(6):938-946
Apoptotic stimuli activate and oligomerize the proapoptotic proteins Bak and Bax, resulting in mitochondrial outer-membrane permeabilization and subsequent cell death. This activation can occur when certain BH3-only proteins interact directly with Ba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d125d296c124e5195b4d4cc6c97813ed
Autor:
Anna Roth, Anthony J. Sadler, Kerstin Jahn-Hofmann, Matthew C.J. Wilce, Die Wang, Jason M. Brouwer, Matthias John, Simone A. Beckham, Jacqueline A. Wilce, Bryan R.G. Williams
Publikováno v:
Nucleic Acids Research
The retinoic acid inducible gene-I (RIG-I)-like family of receptors is positioned at the front line of our innate cellular defence system. RIG-I detects and binds to foreign duplex RNA in the cytoplasm of both immune and non-immune cells, and initiat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82a0cdee54b0c228a51711465017a317
http://europepmc.org/articles/PMC3597671
http://europepmc.org/articles/PMC3597671
Autor:
Rachel T Uren, Ray Bartolo, Jason M. Brouwer, Martin O'Hely, Grant Dewson, Ruth M. Kluck, Sweta Iyer, Amber E. Alsop
During apoptosis, Bak and Bax undergo major conformational change and form symmetric dimers that coalesce to perforate the mitochondrial outer membrane via an unknown mechanism. We have employed cysteine labelling and linkage analysis to the full len
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::139e3b223a1752cfbed7adf4d5ac1f50
https://doi.org/10.1101/059899
https://doi.org/10.1101/059899
Autor:
Mark F, van Delft, Stephane, Chappaz, Yelena, Khakham, Chinh T, Bui, Marlyse A, Debrincat, Kym N, Lowes, Jason M, Brouwer, Christoph, Grohmann, Phillip P, Sharp, Laura F, Dagley, Lucy, Li, Kate, McArthur, Meng-Xiao, Luo, Hui San, Chin, W Douglas, Fairlie, Erinna F, Lee, David, Segal, Stephane, Duflocq, Romina, Lessene, Sabrina, Bernard, Laure, Peilleron, Thao, Nguyen, Caroline, Miles, Soo San, Wan, Rachael M, Lane, Ahmad, Wardak, Kurt, Lackovic, Peter M, Colman, Jarrod J, Sandow, Andrew I, Webb, Peter E, Czabotar, Grant, Dewson, Keith G, Watson, David C S, Huang, Guillaume, Lessene, Benjamin T, Kile
Publikováno v:
Nature chemical biology. 15(11)
Activating the intrinsic apoptosis pathway with small molecules is now a clinically validated approach to cancer therapy. In contrast, blocking apoptosis to prevent the death of healthy cells in disease settings has not been achieved. Caspases have b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0477b40e4e5384654fad1f5b446d351b
https://pubmed.ncbi.nlm.nih.gov/31591564
https://pubmed.ncbi.nlm.nih.gov/31591564