Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Jason M, Newbern"'
Autor:
George R. Bjorklund, Katherina P. Rees, Kavya Balasubramanian, Lauren T. Hewitt, Kenji Nishimura, Jason M. Newbern
Publikováno v:
Disease Models & Mechanisms, Vol 17, Iss 6 (2024)
Externí odkaz:
https://doaj.org/article/4bae5a7266df4e65a3b97c0d36678ef0
Autor:
Alexander B. Andre, Katherina P. Rees, Samantha O’Connor, Grant W. Severson, Jason M. Newbern, Jeanne Wilson-Rawls, Christopher L. Plaisier, Alan Rawls
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Background: The expression of proinflammatory signals at the site of muscle injury are essential for efficient tissue repair and their dysregulation can lead to inflammatory myopathies. Macrophages, neutrophils, and fibroadipogenic progenitor cells r
Externí odkaz:
https://doaj.org/article/67782f314e6b445991619e95e0404d50
Autor:
Michael C Holter, Lauren T Hewitt, Stephanie V Koebele, Jessica M Judd, Lei Xing, Heather A Bimonte-Nelson, Cheryl D Conrad, Toshiyuki Araki, Benjamin G Neel, William D Snider, Jason M Newbern
Publikováno v:
PLoS Genetics, Vol 15, Iss 4, p e1008108 (2019)
RASopathies are a family of related syndromes caused by mutations in regulators of the RAS/Extracellular Regulated Kinase 1/2 (ERK1/2) signaling cascade that often result in neurological deficits. RASopathy mutations in upstream regulatory components
Externí odkaz:
https://doaj.org/article/8dcbf3d7041c4a1a9c70605c26705f53
Autor:
Kimberly T. Meyers, Chelsey C. Damphousse, Annika B. Ozols, Janet M. Campbell, Jason M. Newbern, Chengcheng Hu, Diano F. Marrone, Amelia Gallitano
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ee91c1702ac7061e8ddc6e104f4f51d
https://doi.org/10.2139/ssrn.4355426
https://doi.org/10.2139/ssrn.4355426
Autor:
Sara J. Knowles, April M. Stafford, Tariq Zaman, Kartik Angara, Michael R. Williams, Jason M. Newbern, Daniel Vogt
RAS/MAPK gene dysfunction underlies various cancers and neurocognitive disorders. Although the roles of RAS/MAPK genes have been well studied in cancer, less is known about their function during neurodevelopment. There are many genes that work in con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e053de78a40cfff707941187ad171180
https://doi.org/10.1101/2022.08.04.502867
https://doi.org/10.1101/2022.08.04.502867
Autor:
Sara J. Knowles, Michael C. Holter, Guohui Li, George R. Bjorklund, Katherina P. Rees, Johan S. Martinez-Fuentes, Kenji J. Nishimura, Ariana E. Afshari, Noah Fry, April M Stafford, Daniel Vogt, Marco Mangone, Trent Anderson, Jason M. Newbern
The RAS/RAF/MEK/ERK1/2 intracellular signaling pathway is activated by numerous cues during brain development and dysregulated in neurodevelopmental syndromes, particularly the RASopathies and certain forms of autism. Cortical excitatory/inhibitory i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a1d3f63de4c5dd7660b62f02f9275e1
https://doi.org/10.1101/2022.08.02.502073
https://doi.org/10.1101/2022.08.02.502073
Publikováno v:
Hippocampus. 31:221-231
Past studies find that chronic stress alters inhibitory, GABAergic circuitry of neurons in distinct hippocampal subregions. Less clear is whether these effects persist weeks after chronic stress ends, and whether these effects involve changes in the
Autor:
Kenneth L, Chiou, Alex R, DeCasien, Katherina P, Rees, Camille, Testard, Cailyn H, Spurrell, Aishwarya A, Gogate, Hannah A, Pliner, Sébastien, Tremblay, Arianne, Mercer, Connor J, Whalen, Josué E, Negrón-Del Valle, Mareike C, Janiak, Samuel E, Bauman Surratt, Olga, González, Nicole R, Compo, Michala K, Stock, Angelina V, Ruiz-Lambides, Melween I, Martínez, Melissa A, Wilson, Amanda D, Melin, Susan C, Antón, Christopher S, Walker, Jérôme, Sallet, Jason M, Newbern, Lea M, Starita, Jay, Shendure, James P, Higham, Lauren J N, Brent, Michael J, Montague, Michael L, Platt, Noah, Snyder-Mackler
Publikováno v:
Nat Neurosci
Aging is accompanied by a host of social and biological changes that correlate with behavior, cognitive health and susceptibility to neurodegenerative disease. To understand trajectories of brain aging in a primate, we generated a multiregion bulk (N
Autor:
Lei Xing, Rylan S Larsen, George Reed Bjorklund, Xiaoyan Li, Yaohong Wu, Benjamin D Philpot, William D Snider, Jason M Newbern
Publikováno v:
eLife, Vol 5 (2016)
Aberrant signaling through the Raf/MEK/ERK (ERK/MAPK) pathway causes pathology in a family of neurodevelopmental disorders known as 'RASopathies' and is implicated in autism pathogenesis. Here, we have determined the functions of ERK/MAPK signaling i
Externí odkaz:
https://doaj.org/article/3d381bd76ab04494a1d0fdf55415926c
Autor:
Shannon O'Brien, Heather C. Hrach, Hannah S Steber, Alan Rawls, Marco Mangone, Jason M. Newbern
Publikováno v:
Human Molecular Genetics
Duchenne muscular dystrophy (DMD) is a lethal, X-linked disease characterized by progressive muscle degeneration. The condition is driven by nonsense and missense mutations in the dystrophin gene, leading to instability of the sarcolemma and skeletal