Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Jason M, Cox"'
Autor:
Kritika Khanna, Wilfred W. Raymond, Jing Jin, Annabelle R. Charbit, Irina Gitlin, Monica Tang, Adam D. Werts, Edward G. Barrett, Jason M. Cox, Sharla M. Birch, Rachel Martinelli, Hannah S. Sperber, Sergej Franz, Thomas Duff, Markus Hoffmann, Anne Marie Healy, Stefan Oscarson, Stefan Pöhlmann, Satish K. Pillai, Graham Simmons, John V. Fahy
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 323:L372-L389
The redox status of the cysteine-rich SARS-CoV-2 spike glycoprotein (SARS-2-S) is important for the binding of SARS-2-S to angiotensin-converting enzyme 2 (ACE2), suggesting that drugs with a functional thiol group (“thiol drugs”) may cleave cyst
Autor:
Santhosh Satapati, Ying Qian, Margaret S. Wu, Aleksandr Petrov, Ge Dai, Sheng-ping Wang, Yonghua Zhu, Xiaolan Shen, Eric S. Muise, Ying Chen, Emanuel Zycband, Adam Weinglass, Jerry Di Salvo, John S. Debenham, Jason M. Cox, Ping Lan, Vinit Shah, Stephen F. Previs, Mark Erion, David E. Kelley, Liangsu Wang, Andrew D. Howard, Jin Shang
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 8, Pp 1561-1578 (2017)
GPR40 and GPR120 are fatty acid sensors that play important roles in glucose and energy homeostasis. GPR40 potentiates glucose-dependent insulin secretion and demonstrated in clinical studies robust glucose lowering in type 2 diabetes. GPR120 improve
Externí odkaz:
https://doaj.org/article/1d5d6bb81f4b48f7aa3c095bb5ab4e88
The structural integrity of cancellous bone, which is essential to skeletal load-bearing capacity, is governed chiefly by apparent density, trabecular architecture, and tissue material properties. Metabolic bone disorders such as osteoporosis can aff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a4fbd5539d166c2ac5da36477859bd0
https://doi.org/10.1101/2021.11.30.470675
https://doi.org/10.1101/2021.11.30.470675
Autor:
Kritika, Khanna, Wilfred, Raymond, Jing, Jin, Annabelle R, Charbit, Irina, Gitlin, Monica, Tang, Adam D, Werts, Edward G, Barrett, Jason M, Cox, Sharla M, Birch, Rachel, Martinelli, Hannah S, Sperber, Sergej, Franz, Satish, Pillai, Anne Marie, Healy, Thomas, Duff, Stefan, Oscarson, Markus, Hoffmann, Stefan, Pöhlmann, Graham, Simmons, John V, Fahy
Publikováno v:
bioRxiv : the preprint server for biology.
Neutrophil-induced oxidative stress is a mechanism of lung injury in COVID-19, and drugs with a functional thiol group ("thiol drugs"), especially cysteamine, have anti-oxidant and anti-inflammatory properties that could limit this injury. Thiol drug
Autor:
Jerry Di Salvo, Santhosh Satapati, Mark D. Erion, Jin Shang, Stephen F. Previs, Adam B. Weinglass, John S. Debenham, Margaret Wu, Sheng-Ping Wang, Andrew D. Howard, Ying Chen, Aleksandr Petrov, Ge Dai, Yonghua Zhu, Liangsu Wang, David E. Kelley, Ying Qian, Xiaolan Shen, Eric S. Muise, Jason M. Cox, Ping Lan, Vinit Shah, Emanuel Zycband
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 8, Pp 1561-1578 (2017)
GPR40 and GPR120 are fatty acid sensors that play important roles in glucose and energy homeostasis. GPR40 potentiates glucose-dependent insulin secretion and demonstrated in clinical studies robust glucose lowering in type 2 diabetes. GPR120 improve
Autor:
Hong D. Chu, Huaibing He, Ying-Duo Gao, Xiaohua Li, Aleksandr Petrov, Tesfaye Biftu, Joseph M. Metzger, Jeffrey T. Kuethe, Kathryn A. Lyons, Jason M. Cox, Ranabir SinhaRoy, George J. Eiermann, Ann E. Weber, Shiyao Xu, Giovanna Scapin, Joseph K. Wu
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:2622-2626
Novel potent and selective 5,6,5- and 5,5,6-tricyclic pyrrolidine dipeptidyl peptidase IV (DPP-4) inhibitors were identified. Structure-activity relationship (SAR) efforts focused on improving the intrinsic DPP-4 inhibition potency, increasing protea
Autor:
Elizabeth Smith, Robin E. Haimbach, Li-Jun Ma, Olga Price, David E. Kelley, Yonghua Zhu, Ji Zhang, Yanqing Kan, Xiaoyan Zhou, Margarita Garcia-Calvo, Shirly Pinto, Wei Zhu, Emanuel Zycband, Jason M. Cox, Rosemary Mayer-Ezell, Maarten Hoek
Publikováno v:
Pharmacology Research & Perspectives
Multiple integrins have been implicated in modulating renal function. Modulation of integrin function can lead to pathophysiological processes associated with diabetic nephropathy such as alterations in the glomerular filtration barrier and kidney fi
Autor:
Gaochao Zhou, Judyann Wiltsie, Jason M. Cox, Lisa Contino, Jaume Balsells, Martin Crook, Ling Xu, Joseph Clemas, Hong D. Chu, JeanMarie Lisnock, Jack Gibson, Christine Yang, Thomas Bateman, Zhicai Wu, Peter J. Sinclair, Beata Zamlynny, Hong C. Shen, Margarita Garcia-Calvo, Xinchun Tong, Alejandro Crespo, Patricia Brown
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:4388-4392
Novel oxazolidinedione analogs were discovered as potent and selective mineralocorticoid receptor (MR) antagonists. Structure–activity relationship (SAR) studies were focused on improving the potency and microsomal stability. Selected compounds dem
Autor:
Christopher Joseph Sinz, Sarah Souza, Aimie M. Ogawa, Dennis Leung, Eric R. Ashley, Brande Thomas-Fowlkes, Maria Madeira, Mary Ann Powles, Effie Tozzo, Hong D. Chu, Feroze Ujjainwalla, Melissa Kirkland, Matthew Lombardo, Clare London, Jerry Di Salvo, Keith Eagen, John S. Debenham, Jason M. Cox, Ping Lan, Alejandro Crespo, Adam B. Weinglass, Taro E. Akiyama, Nengxue Wang, Henry M. Vaccaro, Michele Pachanski, Shah Unmesh G, Zhongxiang Sun, Mariappan V. Chelliah, James R. Tata, Michael A. Plotkin, Candice Alleyne, Takao Suzuki, Srikanth Venkatraman
Publikováno v:
ACS medicinal chemistry letters. 8(1)
Type 2 diabetes mellitus (T2DM) is an ever increasing worldwide epidemic, and the identification of safe and effective insulin sensitizers, absent of weight gain, has been a long-standing goal of diabetes research. G-protein coupled receptor 120 (GPR
Autor:
Sangita B. Patel, Scott D. Edmondson, Ann E. Weber, Reshma A. Patel, Aleksandr Petrov, Kathryn A. Lyons, Bing Zhu, Joseph K. Wu, Anthony Mastracchio, Shiyao Xu, George J. Eiermann, Ranabir Sinha Roy, Giovanna Scapin, Nancy A. Thornberry, Jason M. Cox, Huaibing He
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:4097-4101
A new series of DPP-4 inhibitors derived from piperidine-fused benzimidazoles and imidazopyridines is described. Optimization of this class of DPP-4 inhibitors led to the discovery of imidazopyridine 34. The potency, selectivity, cross-species DMPK p