Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Jason Limberis"'
Autor:
Weihao Zheng, I-Chang Chang, Jason Limberis, Jonathan M Budzik, Beth Shoshana Zha, Zachary Howard, Lucas Chen, Joel D Ernst
Publikováno v:
PLoS Pathogens, Vol 20, Iss 5, p e1012205 (2024)
Mycobacterium tuberculosis (Mtb) infects lung myeloid cells, but the specific Mtb-permissive cells and host mechanisms supporting Mtb persistence during chronic infection are incompletely characterized. We report that after the development of T cell
Externí odkaz:
https://doaj.org/article/4dce6a47034b4f2db7cf2ce38e6f5d2a
Autor:
Michele Tomasicchio, Jason Limberis, Ruben van der Merwe, Rachael Jacobson, Richard Meldau, Grant Theron, Mark Nicol, Rob Warren, Keertan Dheda
Publikováno v:
International Journal of Infectious Diseases, Vol 96, Iss , Pp 240-243 (2020)
Objectives: Between-person variability in T-cell-specific interferon-gamma release assay (IGRA) responses and discordance between IGRA test formats are poorly understood. Methods: We evaluated the IFN-γ responses (QuantiFERON-TB Gold-In-Tube [QFT-GI
Externí odkaz:
https://doaj.org/article/3fc580e54caa40a8b0014d235b1f7996
Autor:
Marisa Klopper, Tim Hermanus Heupink, Grant Hill-Cawthorne, Elizabeth Maria Streicher, Anzaan Dippenaar, Margaretha de Vos, Abdallah Musa Abdallah, Jason Limberis, Matthias Merker, Scott Burns, Stefan Niemann, Keertan Dheda, James Posey, Arnab Pain, Robin Mark Warren
Publikováno v:
BMC Medicine, Vol 18, Iss 1, Pp 1-14 (2020)
Abstract Background Atypical Beijing genotype Mycobacterium tuberculosis strains are widespread in South Africa and have acquired resistance to up to 13 drugs on multiple occasions. It is puzzling that these strains have retained fitness and transmis
Externí odkaz:
https://doaj.org/article/94b53d5408b144e69d8124dbfc6439ad
Autor:
Nabila Ismail, PhD, Emmanuel Rivière, MSc, Jason Limberis, PhD, Stella Huo, MSc, John Z Metcalfe, ProfPhD, Rob M Warren, ProfPhD, Annelies Van Rie, ProfPhD
Publikováno v:
The Lancet Microbe, Vol 2, Iss 11, Pp e604-e616 (2021)
Summary: Background: Bedaquiline is a crucial drug for control of rifampicin-resistant tuberculosis. Molecular drug resistance assays could facilitate effective use of bedaquiline and surveillance of drug resistance emergence. To facilitate molecular
Externí odkaz:
https://doaj.org/article/fcd16e4bfa3b4da9a5848998efcff179
Autor:
Charissa C. Naidoo, Georgina R. Nyawo, Imran Sulaiman, Benjamin G. Wu, Carolin T. Turner, Kevin Bu, Zaida Palmer, Yonghua Li, Byron W.P. Reeve, Suventha Moodley, Jennifer G. Jackson, Jason Limberis, Andreas H. Diacon, Paul D. van Helden, Jose C. Clemente, Robin M. Warren, Mahdad Noursadeghi, Leopoldo N. Segal, Grant Theron
Publikováno v:
EBioMedicine, Vol 67, Iss , Pp 103374- (2021)
Background: The relationship between tuberculosis (TB), one of the leading infectious causes of death worldwide, and the microbiome, which is critical for health, is poorly understood. Methods: To identify potential microbiome-host interactions, prof
Externí odkaz:
https://doaj.org/article/2b0b5555619a46c9847ef66452da65ce
Publikováno v:
International Journal of Infectious Diseases, Vol 85, Iss , Pp 74-79 (2019)
Background: Treatment outcomes of patients with extensively drug-resistant tuberculosis (XDR-TB) are suboptimal and treatment options remain limited. Linezolid is associated with improved outcomes but also substantial toxicity, and details about the
Externí odkaz:
https://doaj.org/article/f34256f700f943219d4c2cd487d8e31f
Autor:
Weihao Zheng, I-Chang Chang, Jason Limberis, Jonathan M. Budzik, B. Shoshana Zha, Zach Howard, Lucas Chen, Joel D. Ernst
Mycobacterium tuberculosis(Mtb) infects cells in multiple lung myeloid cell subsets and causes chronic infection despite innate and adaptive immune responses. However, the mechanisms allowing Mtb to evade elimination are not fully understood. Here, u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::940a922143adb5cc8e12711a2797b0ee
https://doi.org/10.1101/2023.01.19.524758
https://doi.org/10.1101/2023.01.19.524758
Autor:
Robin M. Warren, Annelies Van Rie, David M. Engelthaler, Megan Folkerts, Tim H. Heupink, Christopher J. Allender, Jason Limberis, John Z. Metcalfe, Michael G. Whitfield
Publikováno v:
Journal of clinical microbiology
Background: Pyrazinamide is an important component of both drug-susceptible and drug-resistant tuberculosis treatment regimens. Although approximately 50% of rifampicin resistant isolates are also resistant to pyrazinamide, pyrazinamide susceptibilit
Autor:
Rachael Jacobson, Rob Warren, Keertan Dheda, Jason Limberis, Mark P. Nicol, Michele Tomasicchio, Richard Meldau, Ruben van der Merwe, Grant Theron
Publikováno v:
International Journal of Infectious Diseases, Vol 96, Iss, Pp 240-243 (2020)
OBJECTIVES: Between-person variability in T-cell-specific interferon-gamma release assay (IGRA) responses and discordance between IGRA test formats are poorly understood. METHODS: We evaluated the IFN-γ responses (QuantiFERON-TB Gold-In-Tube [QFT-GI
Autor:
Jacob Cardenas, Jonathan M. Blackburn, Anil Pooran, Jinghua Gu, Phindile Gina, Aliasgar Esmail, Thearith Koeuth, Tawanda Gumbo, Michele Tomasicchio, Clemens Hermann, Keertan Dheda, Malika Davids, Jason Limberis, Shashikant Srivastava, L. Mottay, Fawziyah Thompson, Bridget Calder, Richard Meldau
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 201:1277-1291
Rationale: A human model to better understand tuberculosis immunopathogenesis and facilitate vaccine development is urgently needed.Objectives: We evaluated the feasibility, safety, and immunogenic...