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Sex-specific differences in atherosclerosis, thrombospondin-1, and smooth muscle cell differentiation in metabolic syndrome versus non-metabolic syndrome mice

Autor: Shreya Gupta, Saugat Khanal, Neha Bhavnani, Amy Mathias, Jason Lallo, Ariana Kiriakou, Jessica Ferrell, Priya Raman

Publikováno v: Frontiers in Cardiovascular Medicine, Vol 9 (2022)

IntroductionMetabolic syndrome (MetS) amplifies the risks of atherosclerosis. Despite well-known sexual dimorphism in atherosclerosis, underlying mechanisms are poorly understood. Our previous findings highlight a proatherogenic protein, thrombospond

Externí odkaz: https://doaj.org/article/1c6b1ad6b0984bb2be4e9ccbfa78620d

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Deletion of Smooth Muscle O-GlcNAc Transferase Prevents Development of Atherosclerosis in Western Diet-Fed Hyperglycemic ApoE-/- Mice In Vivo

Autor: Saugat Khanal, Neha Bhavnani, Amy Mathias, Jason Lallo, Shreya Gupta, Vahagn Ohanyan, Jessica M. Ferrell, Priya Raman

Publikováno v: International Journal of Molecular Sciences; Volume 24; Issue 9; Pages: 7899

Accumulating evidence highlights protein O-GlcNAcylation as a putative pathogenic contributor of diabetic vascular complications. We previously reported that elevated protein O-GlcNAcylation correlates with increased atherosclerotic lesion formation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f19053803b7e5e0e3aba5a9b7f88e0b

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Abstract 135: Sex-specific Differences In The Role Of TSP1 On Metabolic Syndrome-induced Atherosclerosis

Autor: Shreya Gupta, Saugat Khanal, Amy Mathias, Jason Lallo, Priya Raman

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology. 42

Metabolic syndrome (MetS) amplifies risks of atherosclerotic complications. MetS induces abnormal vascular smooth muscle cell (VSMC) migration and proliferation, hallmark of SMC de-differentiation, crucial in the pathogenesis of atherosclerosis. Desp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::36e37f21418fdbdcb7fb21526b714a49
https://doi.org/10.1161/atvb.42.suppl_1.135

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Abstract 204: Sex-specific Differences In The Role Of TSP1 On Metabolic Syndrome-induced Atherosclerosis

Autor: Shreya Gupta, Saugat Khanal, Amy Mathias, Jason Lallo, Priya Raman

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology. 42

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::482a5d766a1e70d23036ce32f14f0297
https://doi.org/10.1161/atvb.42.suppl_1.204

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Abstract MP48: Smooth Muscle Cell-Specific Deletion Of O-GlcNAc Transferase Impedes Atherosclerotic Lesion Formation In Western Diet-fed Apoe -/- Mice

Autor: Saugat Khanal, Amy Mathias, Jason Lallo, Neha Bhavnani, Shreya Gupta, Priya Raman

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology. 41

Attachment of O-linked N-acetylglucosamine (O-GlcNAc) to nucleocytoplasmic proteins or ‘O-GlcNAcylation’ is a ubiquitous post-translational modification affecting numerous cellular processes. We and others have previously reported that augmented

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b69244d4079960c96f84b5b317ae2cff
https://doi.org/10.1161/atvb.41.suppl_1.mp48

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Abstract P153: Upregulation Of Thrombospondin-1 Associates With Accelerated Atherosclerosis And Reduced Smooth Muscle Cell Differentiation In Metabolic Syndrome

Autor: Shreya Gupta, Saugat Khanal, Amy Mathias, Jason Lallo, Jessica Ferrell, Priya Raman

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology. 41

Hyperglycemia and obesity, characteristic of metabolic syndrome (MetS), are important risk-factors for atherosclerosis. MetS patients manifest increased vascular smooth muscle cell (VSMC) migration and proliferation, hallmark of VSMC phenotypic trans

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::666d3d09c72ac2fa6034a0c6bf5954af
https://doi.org/10.1161/atvb.41.suppl_1.p153

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TSP-1 (Thrombospondin-1) Deficiency Protects ApoE −/− Mice Against Leptin-Induced Atherosclerosis

Autor: Rituparna Ganguly, Sujay Datta, Jason Lallo, Aakaash Patel, Shreya Gupta, Priya Raman, Saugat Khanal, Amy Mathias, Vahagn Ohanyan, Kyle Storm, Soumyadip Sahu

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology. 41

Objective: Hyperleptinemia, hallmark of obesity, is a putative pathophysiologic trigger for atherosclerosis. We previously reported a stimulatory effect of leptin on TSP-1 (thrombospondin-1) expression, a proatherogenic matricellular protein implicat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::26330476126dd417f2fd8e7350c15a93
https://doi.org/10.1161/atvbaha.120.314962

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TSP-1 (Thrombospondin-1) Deficiency Protects ApoE

Autor: Rituparna, Ganguly, Saugat, Khanal, Amy, Mathias, Shreya, Gupta, Jason, Lallo, Soumyadip, Sahu, Vahagn, Ohanyan, Aakaash, Patel, Kyle, Storm, Sujay, Datta, Priya, Raman

Publikováno v: Arterioscler Thromb Vasc Biol

OBJECTIVE –: Hyperleptinemia, hallmark of obesity, is a putative pathophysiologic trigger for atherosclerosis. We previously reported a stimulatory effect of leptin on thrombospondin-1 (TSP-1) expression, a proatherogenic matricellular protein impl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::77a6bcc0b7c4bce9532f8a2959ae5df8
https://pubmed.ncbi.nlm.nih.gov/33327743

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