Zobrazeno 1 - 10
of 256
pro vyhledávání: '"Jason L. Sperry"'
Autor:
Jeremy W. Cannon, Danielle S. Gruen, Ruben Zamora, Noah Brostoff, Kelly Hurst, John H. Harn, Fayten El-Dehaibi, Zhi Geng, Rami Namas, Jason L. Sperry, John B. Holcomb, Bryan A. Cotton, Jason J. Nam, Samantha Underwood, Martin A. Schreiber, Kevin K. Chung, Andriy I. Batchinsky, Leopoldo C. Cancio, Andrew J. Benjamin, Erin E. Fox, Steven C. Chang, Andrew P. Cap, Yoram Vodovotz
Publikováno v:
Communications Medicine, Vol 4, Iss 1, Pp 1-12 (2024)
Abstract Background Optimizing resuscitation to reduce inflammation and organ dysfunction following human trauma-associated hemorrhagic shock is a major clinical hurdle. This is limited by the short duration of pre-clinical studies and the sparsity o
Externí odkaz:
https://doaj.org/article/4ec280b49b694ff292ab1c9cd28a37b5
Autor:
Jack K. Donohue, Danielle S. Gruen, Nidhi Iyanna, John M. Lorence, Joshua B. Brown, Francis X. Guyette, Brian J. Daley, Brian J. Eastridge, Richard S. Miller, Raminder Nirula, Brian G. Harbrecht, Jeffrey A. Claridge, Herb A. Phelan, Gary A. Vercruysse, Terence O’Keeffe, Bellal Joseph, Matthew D. Neal, Timothy R. Billiar, Jason L. Sperry
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract Injury mechanism is an important consideration when conducting clinical trials in trauma. Mechanisms of injury may be associated with differences in mortality risk and immune response to injury, impacting the potential success of the trial.
Externí odkaz:
https://doaj.org/article/fb736ecef55a4e4d8e607f38370a6f96
Autor:
Jack K. Donohue, Jason L. Sperry, Philip C. Spinella, Darrell J. Triulzi, Christine L. Leeper, Mark H. Yazer
Publikováno v:
Hematology, Vol 28, Iss 1 (2023)
ABSTRACTBackground The introduction of low titer group O whole blood (LTOWB) that contains potentially ABO-incompatible plasma and the increasing use of group A plasma, due to shortages of AB plasma, in trauma patients whose ABO group is unknown coul
Externí odkaz:
https://doaj.org/article/d92c028323ad491e8b8ba4a3ec042216
Autor:
Insiyah Campwala, Francis X. Guyette, Joshua B. Brown, Mark H. Yazer, Brian J. Daley, Richard S. Miller, Brian G. Harbrecht, Jeffrey A. Claridge, Herbert A. Phelan, Brian Eastridge, Raminder Nirula, Gary A. Vercruysse, Terence O’Keeffe, Bellal Joseph, Matthew D. Neal, Brian S. Zuckerbraun, Jason L. Sperry
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Trauma resuscitation practices have continued to improve with new advances targeting prehospital interventions. The critical care burden associated with severely injured patients at risk of hemorrhage has been poorly characterized. We aim to
Externí odkaz:
https://doaj.org/article/23d7c40065204928884b17324616d6c2
Autor:
Junru Wu, Anthony Cyr, Danielle S. Gruen, Tyler C. Lovelace, Panayiotis V. Benos, Jishnu Das, Upendra K. Kar, Tianmeng Chen, Francis X. Guyette, Mark H. Yazer, Brian J. Daley, Richard S. Miller, Brian G. Harbrecht, Jeffrey A. Claridge, Herb A. Phelan, Brian S. Zuckerbraun, Matthew D. Neal, Pär I. Johansson, Jakob Stensballe, Rami A. Namas, Yoram Vodovotz, Jason L. Sperry, Timothy R. Billiar, PAMPer study group
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Alterations in lipid metabolism and circulating lipid species have been reported in patients with acute critical illness. Here the authors show that selective rise in systemic phosphatidylethanolamine levels is a common feature of critical illness th
Externí odkaz:
https://doaj.org/article/878ce1521f7b4769bceaa30dfe45f017
Autor:
Jillian Bonaroti, Isabel Billiar, Hamed Moheimani, Junru Wu, Rami Namas, Shimena Li, Upendra K. Kar, Yoram Vodovotz, Matthew D. Neal, Jason L. Sperry, Timothy R. Billiar
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Severe injury is known to cause a systemic cytokine storm that is associated with adverse outcomes. However, a comprehensive assessment of the time-dependent changes in circulating levels of a broad spectrum of protein immune mediators and soluble im
Externí odkaz:
https://doaj.org/article/202257bb628941ccb9b6e5bca7e3f62e
Autor:
Hunter B. Moore, MD, PhD, Matthew D. Neal, MD, Marnie Bertolet, PhD, Brian A. Joughin, PhD, Michael B. Yaffe, MD, PhD, Christopher D. Barrett, MD, Molly A. Bird, BS, Russell P. Tracy, PhD, Ernest E Moore, MD, Jason L. Sperry, MD, Brian S. Zuckerbraun, MD, Myung S. Park, MD, Mitchell J. Cohen, MD, Stephen R. Wisniewski, PhD, James H. Morrissey, PhD, TACTIC Investigators
Publikováno v:
Annals of Surgery Open, Vol 3, Iss 2, p e167 (2022)
Objective:. Trauma-induced coagulopathy (TIC) is provoked by multiple mechanisms and is perceived to be one driver of massive transfusions (MT). Single laboratory values using prothrombin time (INR) or thrombelastography (TEG) are used to clinically
Externí odkaz:
https://doaj.org/article/99cb90e1cb8743f7a15129fd3f2eac4c
Autor:
Insiyah Campwala, Francis X. Guyette, Joshua B. Brown, Peter W. Adams, Barbara J. Early, Mark H. Yazer, Matthew D. Neal, Brian S. Zuckerbraun, Jason L. Sperry
Publikováno v:
BMC Emergency Medicine, Vol 20, Iss 1, Pp 1-11 (2020)
Abstract Objectives With increased focus on early resuscitation methods following injury to improve patient outcomes, studies are employing exception from informed consent (EFIC) enrollment. Few studies have assessed patients’ opinions following pa
Externí odkaz:
https://doaj.org/article/50fbc8a709624048aa2ffa71d8909bff
Autor:
Tianmeng Chen, Matthew J. Delano, Kong Chen, Jason L. Sperry, Rami A. Namas, Ashley J. Lamparello, Meihong Deng, Julia Conroy, Lyle L. Moldawer, Philip A. Efron, Patricia Loughran, Christopher Seymour, Derek C. Angus, Yoram Vodovotz, Wei Chen, Timothy R. Billiar
Publikováno v:
JCI Insight, Vol 6, Iss 2 (2021)
Immune dysfunction is an important factor driving mortality and adverse outcomes after trauma but remains poorly understood, especially at the cellular level. To deconvolute the trauma-induced immune response, we applied single-cell RNA sequencing to
Externí odkaz:
https://doaj.org/article/aa87caa1bd944fb59beac3cbabf37d4a
Autor:
Vincent P. Anto, Joshua B. Brown, Andrew B. Peitzman, Brian S. Zuckerbraun, Matthew D. Neal, Gregory Watson, Raquel Forsythe, Timothy R. Billiar, Jason L. Sperry
Publikováno v:
World Journal of Emergency Surgery, Vol 13, Iss 1, Pp 1-8 (2018)
Abstract Background Blunt cerebrovascular injuries (BCVI) are generally associated with high-energy injury mechanisms. Less is known regarding lower-energy injuries in elderly patients. We sought to determine the incidence of BCVI and characterize cu
Externí odkaz:
https://doaj.org/article/b1fc26eda94a4697bc39ed18df8496f9