Implementation of preemptive DNA sequence-based pharmacogenomics testing across a large academic medical center: The Mayo-Baylor RIGHT 10K Study

Autor: Liewei Wang, Steven E. Scherer, Suzette J. Bielinski, Donna M. Muzny, Leila A. Jones, John Logan Black, Ann M. Moyer, Jyothsna Giri, Richard R. Sharp, Eric T. Matey, Jessica A. Wright, Lance J. Oyen, Wayne T. Nicholson, Mathieu Wiepert, Terri Sullard, Timothy B. Curry, Carolyn R. Rohrer Vitek, Tammy M. McAllister, Jennifer L. St. Sauver, Pedro J. Caraballo, Konstantinos N. Lazaridis, Eric Venner, Xiang Qin, Jianhong Hu, Christie L. Kovar, Viktoriya Korchina, Kimberly Walker, HarshaVardhan Doddapaneni, Tsung-Jung Wu, Ritika Raj, Shawn Denson, Wen Liu, Gauthami Chandanavelli, Lan Zhang, Qiaoyan Wang, Divya Kalra, Mary Beth Karow, Kimberley J. Harris, Hugues Sicotte, Sandra E. Peterson, Amy E. Barthel, Brenda E. Moore, Jennifer M. Skierka, Michelle L. Kluge, Katrina E. Kotzer, Karen Kloke, Jessica M. Vander Pol, Heather Marker, Joseph A. Sutton, Adrijana Kekic, Ashley Ebenhoh, Dennis M. Bierle, Michael J. Schuh, Christopher Grilli, Sara Erickson, Audrey Umbreit, Leah Ward, Sheena Crosby, Eric A. Nelson, Sharon Levey, Michelle Elliott, Steve G. Peters, Naveen Pereira, Mark Frye, Fadi Shamoun, Matthew P. Goetz, Iftikhar J. Kullo, Robert Wermers, Jan A. Anderson, Christine M. Formea, Razan M. El Melik, John D. Zeuli, Joseph R. Herges, Carrie A. Krieger, Robert W. Hoel, Jodi L. Taraba, Scott R. St. Thomas, Imad Absah, Matthew E. Bernard, Stephanie R. Fink, Andrea Gossard, Pamela L. Grubbs, Therese M. Jacobson, Paul Takahashi, Sharon C. Zehe, Susan Buckles, Michelle Bumgardner, Colette Gallagher, Kelliann Fee-Schroeder, Nichole R. Nicholas, Melody L. Powers, Ahmed K. Ragab, Darcy M. Richardson, Anthony Stai, Jaymi Wilson, Joel E. Pacyna, Janet E. Olson, Erica J. Sutton, Annika T. Beck, Caroline Horrow, Krishna R. Kalari, Nicholas B. Larson, Hongfang Liu, Liwei Wang, Guilherme S. Lopes, Bijan J. Borah, Robert R. Freimuth, Ye Zhu, Debra J. Jacobson, Matthew A. Hathcock, Sebastian M. Armasu, Michaela E. McGree, Ruoxiang Jiang, Tyler H. Koep, Jason L. Ross, Matthew G. Hilden, Kathleen Bosse, Bronwyn Ramey, Isabelle Searcy, Eric Boerwinkle, Richard A. Gibbs, Richard M. Weinshilboum

Publikováno v: Genet Med

PURPOSE: The Mayo-Baylor RIGHT 10K Study enabled preemptive, sequence-based pharmacogenomics (PGx)-driven drug prescribing practices in routine clinical care within a large cohort. We also generated the tools and resources necessary for clinical PGx

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8d355d871839420df942f373e190f5c
https://pubmed.ncbi.nlm.nih.gov/35331649

Integrating pharmacogenomics panel testing for supportive care medications in patients with solid tumors

Autor: Christopher B. Grilli, Cindy Azevedo, Katie L. Kunze, Mahesh Seetharam, Michael A. Golafshar, Parminder Singh, Eric Nelson, Jewel Samadder, Sydney Welp, Adrijana Kekic, Jason L. Ross, Tyler Koep, Anne Bofferding

Publikováno v: Journal of Clinical Oncology. 38:e24114-e24114

e24114 Background: Pharmacogenomics (PGx) testing is used increasingly in cancer supportive care for drug and dose selection, and side effects prediction with antidepressants, antiemetics, and pain medications. Genetic variants in genes that encode f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::84fb348b0a0d6d0122e08ce0679f0b53
https://doi.org/10.1200/jco.2020.38.15_suppl.e24114

Mayo Genome Consortia: A Genotype-Phenotype Resource for Genome-Wide Association Studies With an Application to the Analysis of Circulating Bilirubin Levels

Autor: Jean Pierre A. Kocher, Hugues Sicotte, Rachel E. Gullerud, Mariza de Andrade, High Seng Chai, Jyotishman Pathak, Suzette J. Bielinski, John A. Heit, Paul J. Limburg, Christopher G. Chute, Jayant A. Talwalkar, Eric W. Klee, Jason L. Ross, Iftikhar J. Kullo, Gloria M. Petersen

Publikováno v: Mayo Clinic Proceedings. 86:606-614

OBJECTIVE To create a cohort for cost-effective genetic research, the Mayo Genome Consortia (MayoGC) has been assembled with participants from research studies across Mayo Clinic with high-throughput genetic data and electronic medical record (EMR) d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e94d5c0c6ee88cfd055d34e22e9f9a5
https://doi.org/10.4065/mcp.2011.0178

Toward a Learning Health-care System – Knowledge Delivery at the Point of Care Empowered by Big Data and NLP

Autor: Joshua J. Pankratz, Dingcheng Li, Vinod C. Kaggal, Sean P. Murphy, Yanshan Wang, James D. Buntrock, Jason L. Ross, Saeed Mehrabi, Rajeev Chaudhry, Majid Mojarad Rastegar, Ravikumar Komandur Elayavilli, Hongfang Liu, Sunghwan Sohn

Publikováno v: Biomedical Informatics Insights, Vol 2016, Iss Suppl. 1, Pp 13-22 (2016)
Biomedical Informatics Insights, Vol 8s1 (2016)
Biomedical Informatics Insights

The concept of optimizing health care by understanding and generating knowledge from previous evidence, ie, the Learning Health-care System (LHS), has gained momentum and now has national prominence. Meanwhile, the rapid adoption of electronic health

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbff30e11b2138e4f93f48a2762581f7
https://doi.org/10.4137/bii.s37977