Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Jason L. Poulos"'
Publikováno v:
Biomedical Microdevices. 14:187-191
Reconstitution of ion channels and transmembrane proteins in planar lipid bilayer membranes allow for their scientific study in highly controlled environments. Recent work with lipid bilayers formed from mechanically joined monolayers has shown their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e4428f3d77760a0d0fe08346e81ac69
https://doi.org/10.1007/s10544-011-9596-5
https://doi.org/10.1007/s10544-011-9596-5
Publikováno v:
Biosensors and Bioelectronics. 26:2651-2654
Ion channels and transmembrane proteins play key roles in a wide range of physiological processes. Engineered ion channels have been explored as highly sensitive single molecule sensors. Scientific and sensing measurements of ion channel conductance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb1df08de071b3b93bcc59e30f7a7de3
https://doi.org/10.1016/j.bios.2010.01.017
https://doi.org/10.1016/j.bios.2010.01.017
Publikováno v:
Biotechnology Journal. 5:511-514
As a step towards an automated and operator-free ion channel measurement platform we have previously demonstrated a solution formulation for artificial lipid bilayers that enabled the indefinite storage and shipping of frozen bilayer precursors. In t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::347f5830fca3e1295660dc560c384757
https://doi.org/10.1002/biot.200900297
https://doi.org/10.1002/biot.200900297
Autor:
Eugene J. Gillespie, Jacob J. Schmidt, Tae-Joon Jeon, Robert Damoiseaux, Kenneth A. Bradley, Jason L. Poulos
Publikováno v:
Biosensors and Bioelectronics. 24:1806-1810
Measurements of ion channels are important for scientific, sensing and pharmaceutical applications. Reconstitution of ion channels into lipid vesicles and planar lipid bilayers for measurement at the single molecule level is a laborious and slow proc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ac178c5ed7ce2408e9aaa8166bb3389
https://doi.org/10.1016/j.bios.2008.08.041
https://doi.org/10.1016/j.bios.2008.08.041
Publikováno v:
Biomedical Microdevices. 17
The human ether-a-go-go related gene (hERG) encodes the potassium channel Kv11.1, which plays a key role in the cardiac action potential and has been implicated in cardiac disorders as well as a number of off-target pharmaceutical interactions. The e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6ae43339ae5e9705c7377985fa83d7e
https://doi.org/10.1007/s10544-014-9919-4
https://doi.org/10.1007/s10544-014-9919-4
Publikováno v:
Biophysical Journal. 106(2)
TRPV1 measured in lipid bilayers The TRPV1 ion channel is a member of the transient receptor potential ion channel family which is known to respond to temperature, voltage and certain chemicals such as capsaicin. We have engineered a HEK cell line ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6657d37c174de34c6292e2186bf02080
Artificial lipid bilayers have been used to create highly accessible and controllable simulated biological environments for studying membrane structure and function, measurement of ion channels and other membrane proteins, and as scaffolds for single
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e309c74da602396316293e7c367598a2
https://doi.org/10.1016/b978-0-12-374396-1.00086-6
https://doi.org/10.1016/b978-0-12-374396-1.00086-6
Publikováno v:
Biophysical Journal. 96(3)
Although artificially reconstituted lipid bilayers have been used for over four decades for basic scientific research, to host engineered pore proteins for sensing applications, and to measure drug/ion channel interactions, their wider application is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f94401d1b4a5893f43f87b32cf97446
Autor:
Jacob J. Schmidt, Jason L. Poulos
Publikováno v:
Biophysical Journal. 96(3)
Measurements of ion channels are important for scientific, sensing and pharmaceutical applications. Reconstitution of ion channels into lipid vesicles and planar lipid bilayers for measurement at the single molecule level is a laborious and slow proc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd38bc7888f0d2ae9a80124f0dae475a
Publikováno v:
Lab on a chip. 8(10)
The fragility and short lifetimes characteristic of conventionally formed lipid bilayer membranes has necessitated their preparation to be at the time and point of use. By using high freezing-point lipid–solvent mixtures, the process of lipid bilay
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7bbb3c8952f4e2653d249e6797908dc
https://pubmed.ncbi.nlm.nih.gov/18813400
https://pubmed.ncbi.nlm.nih.gov/18813400