Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Jason L. Nyrop"'
Autor:
R. Scott Hoerrner, Juan D. Arredondo, C. Scott Shultz, Takahiro Itoh, Xianghui Wen, Debra J. Wallace, Jason L. Nyrop, Dalian Zhao, Paul G. Bulger, Daniel J. Muzzio, Lushi Tan, Ephraim M. Bassan, Qinghao Chen, Mark Weisel, Sarah J. Dolman, Chengfu Xie, Pintipa Grongsaard
Publikováno v:
Organic Process Research & Development. 16:1069-1081
The development of a convergent, chromatography-free synthesis of an allosteric Akt kinase inhibitor is described. The route comprised 17 total steps and was used to produce kilogram quantities of the target molecule. A key early transformation, for
Publikováno v:
The Journal of Organic Chemistry. 76:993-996
An economical and simple flow mixer based on magnetically driven agitation in a tube (MDAT) is reported. Mixing via MDAT compared favorably to both Tee and multilaminar mixers at low flow and was successfully used to screen and optimize two challengi
Autor:
Sarah J. Dolman, Christopher J. Welch, Jason L. Nyrop, Hallena Rogers, James Cuff, Fiona Lin, Xiaoyi Gong
Publikováno v:
Organic Process Research & Development. 13:1022-1025
The application of a recently developed online HPLC reaction sampling instrument for monitoring flow chemistry reactions is described. The system was found to work well for online analysis of flowing streams at or near atmospheric pressure, allowing