Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Jason K. W. Cheng"'
Autor:
Chengkun Wang, Qiong Xia, Qianhe Zhang, Yuanhao Qu, Stephen Su, Jason K. W. Cheng, Nicholas W. Hughes, Le Cong
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2022)
The development of CRISPR-based gene-editing technologies has brought an unprecedented revolution in the field of genome engineering. Cas12a, a member of the Class 2 Type V CRISPR-associated endonuclease family distinct from Cas9, has been repurposed
Externí odkaz:
https://doaj.org/article/7971de916c8d4e2e84fb86afdfe85239
Autor:
Chengkun Wang, Yuanhao Qu, Jason K. W. Cheng, Nicholas W. Hughes, Qianhe Zhang, Mengdi Wang, Le Cong
Publikováno v:
Nature cell biology. 24(2)
Gene editing is a powerful tool for genome and cell engineering. Exemplified by CRISPR–Cas, gene editing could cause DNA damage and trigger DNA repair processes that are often error-prone. Such unwanted mutations and safety concerns can be exacerba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c4cb3cc13445747e6530c9c2c8dc5c4
https://pubmed.ncbi.nlm.nih.gov/35145221
https://pubmed.ncbi.nlm.nih.gov/35145221
Autor:
Nicholas W. Hughes, Le Cong, Jason K W Cheng, Qiong Xia, Chengkun Wang, Qianhe Zhang, Monte M. Winslow
Publikováno v:
Nucleic Acids Research
Several existing technologies enable short genomic alterations including generating indels and short nucleotide variants, however, engineering more significant genomic changes is more challenging due to reduced efficiency and precision. Here, we deve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dea863f8bc1e2b110e235b556589b5dd
http://europepmc.org/articles/PMC8034634
http://europepmc.org/articles/PMC8034634