Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Jason K. K. Low"'
Autor:
Jayne E. Murray, Emanuele Valli, Giorgio Milazzo, Chelsea Mayoh, Andrew J. Gifford, Jamie I. Fletcher, Chengyuan Xue, Nisitha Jayatilleke, Firoozeh Salehzadeh, Laura D. Gamble, Jourdin R. C. Rouaen, Daniel R. Carter, Helen Forgham, Eric O. Sekyere, Joanna Keating, Georgina Eden, Sophie Allan, Stephanie Alfred, Frances K. Kusuma, Ashleigh Clark, Hannah Webber, Amanda J. Russell, Antoine de Weck, Benjamin T. Kile, Martina Santulli, Piergiuseppe De Rosa, Emmy D. G. Fleuren, Weiman Gao, Lorna Wilkinson-White, Jason K. K. Low, Joel P. Mackay, Glenn M. Marshall, Douglas J. Hilton, Federico M. Giorgi, Jan Koster, Giovanni Perini, Michelle Haber, Murray D. Norris
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract MYCN oncogene amplification is frequently observed in aggressive childhood neuroblastoma. Using an unbiased large-scale mutagenesis screen in neuroblastoma-prone transgenic mice, we identify a single germline point mutation in the transcript
Externí odkaz:
https://doaj.org/article/ee532e0c05a8415d9de099a04d9f475c
Autor:
Yichen Zhong, Hakimeh Moghaddas Sani, Bishnu P. Paudel, Jason K. K. Low, Ana P. G. Silva, Stefan Mueller, Chandrika Deshpande, Santosh Panjikar, Xavier J. Reid, Max J. Bedward, Antoine M. van Oijen, Joel P. Mackay
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
CHD4 is an essential chromatin remodelling enzyme in complex organisms. Here the authors demonstrate that CHD4 activity is regulated both positively and negatively by distinct auxiliary domains, revealing parallels with other chromatin remodellers.
Externí odkaz:
https://doaj.org/article/344de9654b7241baa0c94cef93c12913
Autor:
Lipin Loo, Matthew A. Waller, Cesar L. Moreno, Alexander J. Cole, Alberto Ospina Stella, Oltin-Tiberiu Pop, Ann-Kristin Jochum, Omar Hasan Ali, Christopher E. Denes, Zina Hamoudi, Felicity Chung, Anupriya Aggarwal, Jason K. K. Low, Karishma Patel, Rezwan Siddiquee, Taeyoung Kang, Suresh Mathivanan, Joel P. Mackay, Wolfram Jochum, Lukas Flatz, Daniel Hesselson, Stuart Turville, G. Gregory Neely
Publikováno v:
PLoS Biology, Vol 21, Iss 2 (2023)
Although ACE2 is the primary receptor for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection, a systematic assessment of host factors that regulate binding to SARS-CoV-2 spike protein has not been described. Here, we use whole-gen
Externí odkaz:
https://doaj.org/article/b23da8ae80bf4c039eff72357ad89c27
Autor:
Claudio Counoupas, Matt D. Johansen, Alberto O. Stella, Duc H. Nguyen, Angela L. Ferguson, Anupriya Aggarwal, Nayan D. Bhattacharyya, Alice Grey, Owen Hutchings, Karishma Patel, Rezwan Siddiquee, Erica L. Stewart, Carl G. Feng, Nicole G. Hansbro, Umaimainthan Palendira, Megan C. Steain, Bernadette M. Saunders, Jason K. K. Low, Joel P. Mackay, Anthony D. Kelleher, Warwick J. Britton, Stuart G. Turville, Philip M. Hansbro, James A. Triccas
Publikováno v:
npj Vaccines, Vol 6, Iss 1, Pp 1-10 (2021)
Abstract Global control of COVID-19 requires broadly accessible vaccines that are effective against SARS-CoV-2 variants. In this report, we exploit the immunostimulatory properties of bacille Calmette-Guérin (BCG), the existing tuberculosis vaccine,
Externí odkaz:
https://doaj.org/article/54cf1269f483428f921decb5fa5ac562
Autor:
Alexander Norman, Charlotte Franck, Mary Christie, Paige M. E. Hawkins, Karishma Patel, Anneliese S. Ashhurst, Anupriya Aggarwal, Jason K. K. Low, Rezwan Siddiquee, Caroline L. Ashley, Megan Steain, James A. Triccas, Stuart Turville, Joel P. Mackay, Toby Passioura, Richard J. Payne
Publikováno v:
ACS Central Science, Vol 7, Iss 6, Pp 1001-1008 (2021)
Externí odkaz:
https://doaj.org/article/0a46d203a8ab4df88c42556e3ac1d0dd
Autor:
Yichen Zhong, Bishnu P. Paudel, Daniel P. Ryan, Jason K. K. Low, Charlotte Franck, Karishma Patel, Max J. Bedward, Mario Torrado, Richard J. Payne, Antoine M. van Oijen, Joel P. Mackay
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Chromatin remodellers hydrolyse ATP to move nucleosomal DNA against histone octamers. Here, the authors use single-molecule assays to examine the mechanism of action of CHD4 remodeller, and provide evidence that CHD4 slides nucleosomes by decoupling
Externí odkaz:
https://doaj.org/article/848eae28baf44153b8dee9ed3f4508b7
Autor:
Stephanie Link, Ramona M. M. Spitzer, Maryam Sana, Mario Torrado, Moritz C. Völker-Albert, Eva C. Keilhauer, Thomas Burgold, Sebastian Pünzeler, Jason K. K. Low, Ida Lindström, Andrea Nist, Catherine Regnard, Thorsten Stiewe, Brian Hendrich, Axel Imhof, Matthias Mann, Joel P. Mackay, Marek Bartkuhn, Sandra B. Hake
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
PWWP2A is a chromatin-binding transcriptional regulator that mediates mitosis-progression. Here, the authors provide evidence that PWWP2A directly interacts with H2A.Z nucleosomes, DNA and H3K36me3, binds to an MTA1-specific subcomplex of the NuRD co
Externí odkaz:
https://doaj.org/article/014b47e5311d4e1aa8fa73d95eb91cdd
Autor:
Jason K K Low, Karishma Patel, Paul Solomon, Alexander Norman, Petr Pachl, Natasha Jones, Richard J Payne, Toby Passioura, Hiroaki Suga, Louise J Walport, Joel P Mackay
Bromodomains regulate gene expression by recognizing protein motifs containing acetyllysine. Although originally characterized as histone-binding proteins, it has since become clear that these domains interact with other acetylated proteins, perhaps
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27ab2199ddb8297634faec9650223e54
https://doi.org/10.1101/2023.05.17.541126
https://doi.org/10.1101/2023.05.17.541126
Autor:
Tara K. Bartolec, Xabier Vázquez-Campos, Alexander Norman, Clement Luong, Marcus Johnson, Richard J. Payne, Marc R. Wilkins, Joel P. Mackay, Jason K. K. Low
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Significant recent advances in structural biology, particularly in the field of cryoelectron microscopy, have dramatically expanded our ability to create structural models of proteins and protein complexes. However, many proteins remain refractory to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2297b89303e586dc0816ccfa2a0aa604
https://doi.org/10.1073/pnas.2219418120
https://doi.org/10.1073/pnas.2219418120
Autor:
Tara K. Bartolec, Xabier Vázquez-Campos, Alexander Norman, Clement Luong, Richard J. Payne, Marc R. Wilkins, Joel P. Mackay, Jason K. K. Low
Significant recent advances in structural biology, particularly in the field of cryo-electron microscopy, have dramatically expanded our ability to create structural models of proteins and protein complexes. However, many proteins remain refractory t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::85725471ceaac38881f1a80a9fc0e70f
https://doi.org/10.1101/2022.11.16.516813
https://doi.org/10.1101/2022.11.16.516813