Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Jason K. Higa"'
The Role of Ferroptosis in Adverse Left Ventricular Remodeling Following Acute Myocardial Infarction
Publikováno v:
Cells, Vol 11, Iss 9, p 1399 (2022)
Ferroptosis is an iron-dependent form of regulated cell death and is distinct from other conventional forms of regulated cell death. It is often characterized by the dysfunction of the antioxidant selenoprotein glutathione peroxidase 4 (GPX4) antioxi
Externí odkaz:
https://doaj.org/article/7032bad51aba4ad09e89a5e43ed202e1
Autor:
Briana K. Shimada, Naaiko Yorichika, Jason K. Higa, Yuichi Baba, Motoi Kobayashi, Toshinori Aoyagi, Tomohiro Suhara, Takashi Matsui
Publikováno v:
Physiological Reports, Vol 9, Iss 6, Pp n/a-n/a (2021)
Abstract The mechanistic target of rapamycin (mTOR) is a key mediator of energy metabolism, cell growth, and survival. While previous studies using transgenic mice with cardiac‐specific overexpression of mTOR (mTOR‐Tg) demonstrated the protective
Externí odkaz:
https://doaj.org/article/042ba68a7c4741258784f2e28684b7b3
Autor:
Sumit Kar, Shi Su, Nicholas K. Kawasaki, Takashi Matsui, Adriana Adameova, Paras Kumar Mishra, James M. Downey, Jagat Narula, Peter M. Kang, Joseph A. Hill, Christopher P. Baines, Antonio Abbate, Hande Piristine, Jason K. Higa, Masafumi Takahashi
Publikováno v:
Am J Physiol Heart Circ Physiol
Cell death is a fundamental process in cardiac pathologies. Recent studies have revealed multiple forms of cell death, and several of them have been demonstrated to underlie adverse cardiac remodeling and heart failure. With the expansion in the area
Autor:
Tomohiro Suhara, Takashi Matsui, Yuichi Baba, Motoi Kobayashi, Jason K. Higa, Briana K. Shimada, Naaiko Yorichika, Toshinori Aoyagi
Publikováno v:
Physiological Reports
Physiological Reports, Vol 9, Iss 6, Pp n/a-n/a (2021)
Physiological Reports, Vol 9, Iss 6, Pp n/a-n/a (2021)
The mechanistic target of rapamycin (mTOR) is a key mediator of energy metabolism, cell growth, and survival. While previous studies using transgenic mice with cardiac‐specific overexpression of mTOR (mTOR‐Tg) demonstrated the protective effects
Autor:
Motoi Kobayashi, Takashi Matsui, Tomohiro Suhara, Yuichi Baba, Jason K. Higa, Nicholas K. Kawasaki
Publikováno v:
Current Drug Targets. 19:1068-1076
Iron is an essential mineral required for a variety of vital biological functions. Despite being vital for life, iron also has potentially toxic aspects. Iron has been investigated as a risk factor for coronary artery disease (CAD), however, iron's t
Autor:
Takashi Matsui, Hiroko Aoyagi, Briana K. Shimada, Kate M. Horiuchi, Motoi Kobayashi, Hiroaki Kitaoka, Yuichi Baba, Tomohiro Suhara, Jonathan D. Woo, Jason K. Higa, Karra S. Marh
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 314:H659-H668
Clinical studies have suggested that myocardial iron is a risk factor for left ventricular remodeling in patients after myocardial infarction. Ferroptosis has recently been reported as a mechanism of iron-dependent nonapoptotic cell death. However, f
Publikováno v:
American journal of physiology. Heart and circulatory physiology. 316(3)
β-Adrenergic receptor (β-AR) stimulation increases extracellular levels of ubiquitin (UB) in myocytes, and exogenous UB decreases β-AR-stimulated myocyte apoptosis and myocardial fibrosis. Here, we hypothesized that exogenous UB modulates the infl
Publikováno v:
Ferroptosis in Health and Disease ISBN: 9783030267797
Ferroptosis is a relatively newly discovered form of cell death, and although studies confirm its mechanisms in a variety of tissues and diseases, few studies confirm its mechanisms in the heart. The heart depends on iron for its constant energy dema
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89f3757969105efb799aa7e442156df9
https://doi.org/10.1007/978-3-030-26780-3_9
https://doi.org/10.1007/978-3-030-26780-3_9
Autor:
Jagat Narula, Paras Kumar Mishra, Shi Su, Antonio Abbate, James M. Downey, Hande Piristine, Peter M. Kang, Jason K. Higa, Sumit Kar, Takashi Matsui, Masafumi Takahashi, Adriana Adameova, Christopher P. Baines, Nicholas K. Kawasaki, Joseph A. Hill
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 317:H1390-H1390
Cell death is a fundamental process in cardiac pathologies. Recent studies have revealed multiple forms of cell death, and several of them have been demonstrated to underlie adverse cardiac remodeling and heart failure. With the expansion in the area
Publikováno v:
Curr Diab Rep
PURPOSE OF REVIEW: Type 2 diabetes mellitus (T2DM) is a risk factor for heart failure. The mechanistic target of rapamycin (mTOR) is a key mediator of the insulin signaling pathway. We will discuss the role of mTOR in myocardial dysfunction in T2DM.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::811e60a7d97f0b4dc6bc10e2cb600c5c
https://europepmc.org/articles/PMC8219468/
https://europepmc.org/articles/PMC8219468/