Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Jason K. Cheung"'
Autor:
David Rosen, Laurence Fayadat-Dilman, Yiwei Zhang, Konstantin Dobrenkov, Elliot Chartash, Richard Wnek, Smita Mauze, Hans van Eenennaam, Judith Stammen-Vogelzangs, Ying Yu, Marco Guadagnoli, Lars Guelen, Thierry O Fischmann, Jerelyn Wong, Nikolina Bąbała, Jozef Wagenaars, Veronica Juan, Winnie Prosise, Maurice Habraken, Imke Lodewijks, Danling Gu, Jeanne Baker, David Lutje Hulsik, Lilian Driessen-Engels, Dan Malashock, Joost Kreijtz, Astrid Bertens, Evert de Vries, Astrid Bovens, Arne Bramer, Sean Troth, Svetlana Sadekova, Andrea van Elsas, Jason K Cheung, Jannie Borst, Amy M Beebe
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 9 (2022)
Background Immune checkpoint inhibitors (ICI) have radically changed cancer therapy, but most patients with cancer are unresponsive or relapse after treatment. MK-5890 is a CD27 agonist antibody intended to complement ICI therapy. CD27 is a member of
Externí odkaz:
https://doaj.org/article/cc59fd0a12e04837b4168ce751ae8a2b
Publikováno v:
Advanced Drug Delivery Reviews. 174:1-29
Protein therapeutics carry inherent limitations of membrane impermeability and structural instability, despite their predominant role in the modern pharmaceutical market. Effective formulations are needed to overcome physiological and physicochemical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49505b6af11589218d1fdfeb58dea3c3
https://doi.org/10.1016/j.addr.2021.02.007
https://doi.org/10.1016/j.addr.2021.02.007
Publikováno v:
The Protein Journal. 39:318-327
The temperature-dependent secondary structure of two monoclonal IgG antibodies, anti-IGF1R and anti-TSLP, were examined by transmission mode Fourier Transform Infrared (FTIR) spectroscopy. Anti-IGF1R and anti-TSLP are IgG monoclonal antibodies (mAbs)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::092fb0096a7c8b0a3e89f32d801babc9
https://doi.org/10.1007/s10930-020-09907-y
https://doi.org/10.1007/s10930-020-09907-y
Autor:
Lars Guelen, Thierry O Fischmann, Jerelyn Wong, Smita Mauze, Marco Guadagnoli, Nikolina Bąbała, Jozef Wagenaars, Veronica Juan, David Rosen, Winnie Prosise, Maurice Habraken, Imke Lodewijks, Danling Gu, Judith Stammen-Vogelzangs, Ying Yu, Jeanne Baker, David Lutje Hulsik, Lilian Driessen-Engels, Dan Malashock, Joost Kreijtz, Astrid Bertens, Evert de Vries, Astrid Bovens, Arne Bramer, Yiwei Zhang, Richard Wnek, Sean Troth, Elliot Chartash, Konstantin Dobrenkov, Svetlana Sadekova, Andrea van Elsas, Jason K Cheung, Laurence Fayadat-Dilman, Jannie Borst, Amy M Beebe, Hans Van Eenennaam
Publikováno v:
Journal for ImmunoTherapy of Cancer, 10(9). BMJ PUBLISHING GROUP
BackgroundImmune checkpoint inhibitors (ICI) have radically changed cancer therapy, but most patients with cancer are unresponsive or relapse after treatment. MK-5890 is a CD27 agonist antibody intended to complement ICI therapy. CD27 is a member of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92e2a5657834d447f836b811d356fb97
https://doi.org/10.1136/jitc-2022-005049
https://doi.org/10.1136/jitc-2022-005049
Autor:
Tony Y. Shay, Carl A. Karouta, Ayush Sharma, Amjad Chowdhury, Jessica J. Hung, Keith P. Johnston, Maria P. Nieto, Kishan Ramachandran, Logan R. Wilks, Barton J. Dear, Thomas M. Truskett, Jason K. Cheung
Publikováno v:
Industrial & Engineering Chemistry Research. 58:22456-22471
To understand and predict the viscosities of highly concentrated monoclonal antibody (mAb) solutions, it is important to characterize the protein–protein interactions (PPI) and how they influence t...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6e2a159f2a08f08392b26692f736a02
https://doi.org/10.1021/acs.iecr.9b03432
https://doi.org/10.1021/acs.iecr.9b03432
Autor:
Jason K. Cheung, Tony Y. Shay, Thomas M. Truskett, Carl C. Hayden, Maria P. Nieto, Barton J. Dear, Carl A. Karouta, Wade F. Zeno, Keith P. Johnston, Amjad Chowdhury, Jeanne C. Stachowiak, Jessica J. Hung, Kishan Ramachandran
Publikováno v:
Soft Matter. 15:6660-6676
The dynamic behavior of monoclonal antibodies (mAbs) at high concentration provides insight into protein microstructure and protein-protein interactions (PPI) that influence solution viscosity and protein stability. At high concentration, interpretat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e66f4db2c89ca7b3bdce0c4f43f8e98e
https://doi.org/10.1039/c9sm01071h
https://doi.org/10.1039/c9sm01071h
Autor:
Dongdong Wang, Jason K. Cheung, Christine Nowak, Yingda Xu, Ning Li, Wei Xu, Bruce Mason, Tony Rossomando, Dingjiang Liu, Diane D Dong, Alain Beck, Joanne Sun, Amit Katiyar, Tao Xiang, Hongcheng Liu, Smita Raghava
Publikováno v:
mAbs. 11:239-264
Increasing attention has been paid to developability assessment with the understanding that thorough evaluation of monoclonal antibody lead candidates at an early stage can avoid delays during late-stage development. The concept of developability is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::403349622c416a603ec56c3e5223e638
https://doi.org/10.1080/19420862.2018.1553476
https://doi.org/10.1080/19420862.2018.1553476
Publikováno v:
PDA journal of pharmaceutical science and technology. 75(3)
Traditional statistical analyses of subvisible particle data are usually based on either descriptive statistics, normal-based methods, or standard Poisson models. These methods often do not adequately describe the counts or particle size distribution
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f197da059d70a4af62ba2bc80944e3c7
https://pubmed.ncbi.nlm.nih.gov/33199515
https://pubmed.ncbi.nlm.nih.gov/33199515
Autor:
Jason K. Cheung, Keith P. Johnston, Amjad Chowdhury, Barton J. Dear, Thomas M. Truskett, Jonathan A. Bollinger
Publikováno v:
Molecular pharmaceutics. 17(5)
Understanding protein-protein interactions in concentrated therapeutic monoclonal antibody (mAb) solutions is desirable for improved drug discovery, processing, and administration. Here, we deduce both the net protein charge and the magnitude and geo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2edb670d6a0b8833d544ba0897bb7f9
https://pubmed.ncbi.nlm.nih.gov/32101441
https://pubmed.ncbi.nlm.nih.gov/32101441
Autor:
P. Douglas Godfrin, Jessica J. Hung, Tony Y. Shay, Jason K. Cheung, Ayush Sharma, Keith P. Johnston, Maria P. Nieto, Amjad Chowdhury, Thomas M. Truskett, Dmytro Nykypanchuk, Jonathan A. Bollinger, Barton J. Dear, Carl A. Karouta, Kishan Ramachandran, Logan R. Wilks
Publikováno v:
The journal of physical chemistry. B. 123(25)
Attractive protein?protein interactions (PPI) in concentrated monoclonal antibody (mAb) solutions may lead to reversible oligomers (clusters) that impact colloidal stability and viscosity. Herein, the PPI are tuned for two mAbs via the addition of ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb07e838aca0990d52e38a8794c881ed
https://pubmed.ncbi.nlm.nih.gov/31146525
https://pubmed.ncbi.nlm.nih.gov/31146525