Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Jason K Sello"'
Autor:
David W Morgens, Charlene Chan, Andrew J Kane, Nicholas R Weir, Amy Li, Michael M Dubreuil, C Kimberly Tsui, Gaelen T Hess, Adam Lavertu, Kyuho Han, Nicole Polyakov, Jing Zhou, Emma L Handy, Philip Alabi, Amanda Dombroski, David Yao, Russ B Altman, Jason K Sello, Vladimir Denic, Michael C Bassik
Publikováno v:
eLife, Vol 8 (2019)
The small molecule Retro-2 prevents ricin toxicity through a poorly-defined mechanism of action (MOA), which involves halting retrograde vesicle transport to the endoplasmic reticulum (ER). CRISPRi genetic interaction analysis revealed Retro-2 activi
Externí odkaz:
https://doaj.org/article/f8b0b64eb9da49ff8b1b2ae4b6712fa1
Autor:
Evan Craig, Charles-Eugene Huyghues-Despointes, Chun Yu, Emma L Handy, Jason K Sello, Peter E Kima
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 11, Iss 5, p e0005556 (2017)
In infected mammalian cells, Leishmania parasites reside within specialized compartments called parasitophorous vacuoles (LPVs). We have previously shown that Retro-2, a member of a novel class of small retrograde pathway inhibitors caused reduced LP
Externí odkaz:
https://doaj.org/article/bf7770f55c804ed49eee5c3ec3267f42
Autor:
Marios Arvanitis, Gang Li, De-Dong Li, Daniel Cotnoir, Lisa Ganley-Leal, Daniel W Carney, Jason K Sello, Eleftherios Mylonakis
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0153912 (2016)
Cyclic acyldepsipeptides (ADEPs) are a novel class of antibacterial agents, some of which (e.g., ADEP 4) are highly active against Gram-positive bacteria. The focus of these in vivo studies is ADEP B315, a rationally designed compound that has the mo
Externí odkaz:
https://doaj.org/article/18ad74b3db3546f6a56a4490daeb051a
Autor:
Philip E. Alabi, Cécile Gautier, Thomas P. Murphy, Xilin Gu, Mathieu Lepas, Vishukumar Aimanianda, Jason K. Sello, Iuliana V. Ene
Publikováno v:
mBio, Vol 14, Iss 4 (2023)
ABSTRACT Each year, fungi cause more than 1.5 billion infections worldwide and have a devastating impact on human health, particularly in immunocompromised individuals or patients in intensive care units. The limited antifungal arsenal and emerging m
Externí odkaz:
https://doaj.org/article/15b990d5aad149fea455387c64e3f1e9
Autor:
Evan Craig, Anna Calarco, Raffaele Conte, Veronica Ambrogi, Giovanna Gomez d’Ayala, Philip Alabi, Jason K. Sello, Pierfrancesco Cerruti, Peter E. Kima
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
Clinical manifestations of leishmaniasis range from self-healing, cutaneous lesions to fatal infections of the viscera. With no preventative Leishmania vaccine available, the frontline option against leishmaniasis is chemotherapy. Unfortunately, curr
Externí odkaz:
https://doaj.org/article/fbf6f700420e4edbaa3fd4ce339c114f
Autor:
Siwen Wang, Zhonghan Li, Desiree Aispuro, Nathan Guevara, Juno Van Valkenburgh, Boxi Chen, Xiaoyun Zhou, Matthew N. McCarroll, Fei Ji, Xu Cong, Priyanka Sarkar, Rohit Chaudhuri, Zhili Guo, Nicole P. Perkins, Shiqun Shao, Jason K. Sello, Kai Chen, Min Xue
Publikováno v:
Journal of the American Chemical Society, vol 144, iss 44
Delivering cargo molecules across the plasma membrane is critical for biomedical research, and the need to develop molecularly well-defined tags that enable cargo transportation is ever-increasing. We report here a hydrophilic endocytosis-promoting p
Autor:
Philip E. Alabi, Cécile Gautier, Thomas P. Murphy, Xilin Gu, Mathieu Lepas, Vishukumar Aimanianda, Jason K. Sello, Iuliana V. Ene
Each year, fungi cause more than 1.5 billion infections worldwide and have a devastating impact on human health, particularly in immunocompromised individuals or patients in intensive care units. The limited antifungal arsenal and emerging multidrug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26fb5ddcc849cc2c94733fcf14819f14
https://doi.org/10.1101/2022.03.31.486631
https://doi.org/10.1101/2022.03.31.486631
Autor:
Jason K. Sello, Shashank Gupta, Robert T. Sauer, Emma L. Handy, Corey L. Compton, William R. Bishai, Karl R. Schmitz
Publikováno v:
ACS Chemical Biology. 18:724-733
Proteolytic complexes in Mycobacterium tuberculosis (Mtb), the deadliest bacterial pathogen, are major foci in tuberculosis drug development programs. The Clp proteases, which are essential for Mtb viability, are high priority targets. These protease
Autor:
Giovanna Gomez d'Ayala, Evan Craig, Jason K. Sello, Philip Alabi, Anna Calarco, Peter E. Kima, Raffaele Conte, Pierfrancesco Cerruti, Veronica Ambrogi
Publikováno v:
Frontiers in cellular and infection microbiology 11 (2021). doi:10.3389/fcimb.2021.702676
info:cnr-pdr/source/autori:Craig, Evan; Calarco, Anna; Conte, Raffaele; Ambrogi, Veronica; d'Ayala, Giovanna Gomez; Alabi, Philip; Sello, Jason K.; Cerruti, Pierfrancesco; Kima, Peter E./titolo:Thermoresponsive Copolymer Nanovectors Improve the Bioavailability of Retrograde Inhibitors in the Treatment of Leishmania Infections/doi:10.3389%2Ffcimb.2021.702676/rivista:Frontiers in cellular and infection microbiology/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume:11
Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
Frontiers in Cellular and Infection Microbiology
info:cnr-pdr/source/autori:Craig, Evan; Calarco, Anna; Conte, Raffaele; Ambrogi, Veronica; d'Ayala, Giovanna Gomez; Alabi, Philip; Sello, Jason K.; Cerruti, Pierfrancesco; Kima, Peter E./titolo:Thermoresponsive Copolymer Nanovectors Improve the Bioavailability of Retrograde Inhibitors in the Treatment of Leishmania Infections/doi:10.3389%2Ffcimb.2021.702676/rivista:Frontiers in cellular and infection microbiology/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume:11
Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
Frontiers in Cellular and Infection Microbiology
Clinical manifestations of leishmaniasis range from self-healing, cutaneous lesions to fatal infections of the viscera. With no preventative Leishmania vaccine available, the frontline option against leishmaniasis is chemotherapy. Unfortunately, curr
Autor:
Ruth M. Colwill, Robbert Creton, Elizabeth S. Kahn, Danielle E. Clift, Peter Baek, Tania M. Dominguez-Gonzalez, Kerry Eller, Renee J. Seto, Sara K. Tucker, Robert J. Thorn, Amanda Dombroski, Jason K. Sello
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Scientific Reports
Scientific Reports
Visual impairment affects 253 million people worldwide and new approaches for prevention and treatment are urgently needed. While small molecules with potential beneficial effects can be examined in various model systems, the in vivo evaluation of vi