Zobrazeno 1 - 10
of 284
pro vyhledávání: '"Jason K, Kim"'
Autor:
Randall H. Friedline, Hye Lim Noh, Sujin Suk, Mahaa Albusharif, Sezin Dagdeviren, Suchaorn Saengnipanthkul, Bukyung Kim, Allison M. Kim, Lauren H. Kim, Lauren A. Tauer, Natalie M. Baez Torres, Stephanie Choi, Bo-Yeon Kim, Suryateja D. Rao, Kaushal Kasina, Cheng Sun, Benjamin J. Toles, Chan Zhou, Zixiu Li, Vivian M. Benoit, Payal R. Patel, Doris X. T. Zheng, Kunikazu Inashima, Annika Beaverson, Xiaodi Hu, Duy A. Tran, Werner Muller, Dale L. Greiner, Alan C. Mullen, Ki Won Lee, Jason K. Kim
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Obesity is a major cause of metabolic dysfunction-associated steatohepatitis (MASH) and is characterized by inflammation and insulin resistance. Interferon-γ (IFNγ) is a pro-inflammatory cytokine elevated in obesity and modulating macropha
Externí odkaz:
https://doaj.org/article/8e5cb5e93c2e43288feb95e635cd27f8
Autor:
Randall H. Friedline, Hye Lim Noh, Sujin Suk, Mahaa Albusharif, Sezin Dagdeviren, Suchaorn Saengnipanthkul, Bukyung Kim, Allison M. Kim, Lauren H. Kim, Lauren A. Tauer, Natalie M. Baez Torres, Stephanie Choi, Bo-Yeon Kim, Suryateja D. Rao, Kaushal Kasina, Cheng Sun, Benjamin J. Toles, Chan Zhou, Zixiu Li, Vivian M. Benoit, Payal R. Patel, Doris X. T. Zheng, Kunikazu Inashima, Annika Beaverson, Xiaodi Hu, Duy A. Tran, Werner Muller, Dale L. Greiner, Alan C. Mullen, Ki Won Lee, Jason K. Kim
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/4fd7ed9712ca43fbbfea0936d917d2b4
Autor:
Emmanouela Tsagkaraki, Adilson Guilherme, Sarah M. Nicoloro, Mark Kelly, Lawrence M. Lifshitz, Hui Wang, Kyounghee Min, Leslie A. Rowland, Kaltinaitis B. Santos, Nicole Wetoska, Randall H. Friedline, Stacy A. Maitland, Min Chen, Lee S. Weinstein, Scot A. Wolfe, Jason K. Kim, Michael P. Czech
Publikováno v:
Molecular Metabolism, Vol 76, Iss , Pp 101780- (2023)
Objectives: Nuclear receptor interacting protein 1 (NRIP1) suppresses energy expenditure via repression of nuclear receptors, and its depletion markedly elevates uncoupled respiration in mouse and human adipocytes. We tested whether NRIP1 deficient a
Externí odkaz:
https://doaj.org/article/8509853fb6d444bb83dafa8e5ebf8337
Autor:
Qingbo Chen, Lei Huang, Dongning Pan, Kai Hu, Rui Li, Randall H. Friedline, Jason K. Kim, Lihua Julie Zhu, David A. Guertin, Yong-Xu Wang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
The signaling mechanisms regulating adipose thermogenesis have not been fully elucidated. Here, the authors show that a brown fat-enriched adipokine ADISSP promotes adipose thermogenesis and improves metabolic health independently of b-adrenergic rec
Externí odkaz:
https://doaj.org/article/8345619aee974758834d427199e5cc83
Autor:
Ye Tian, Kritika Mehta, Matthew J. Jellinek, Hao Sun, Wei Lu, Ruicheng Shi, Kevin Ingram, Randall H. Friedline, Jason K. Kim, Jongsook Kim Kemper, David A. Ford, Kai Zhang, Bo Wang
Publikováno v:
Advanced Science, Vol 10, Iss 18, Pp n/a-n/a (2023)
Abstract The liver plays a central role in regulating glucose and lipid metabolism. Aberrant insulin action in the liver is a major driver of selective insulin resistance, in which insulin fails to suppress glucose production but continues to activat
Externí odkaz:
https://doaj.org/article/9b28f14487204e688c30990ee63d6620
Autor:
Adilson Guilherme, Leslie A. Rowland, Nicole Wetoska, Emmanouela Tsagkaraki, Kaltinaitis B. Santos, Alexander H. Bedard, Felipe Henriques, Mark Kelly, Sean Munroe, David J. Pedersen, Olga R. Ilkayeva, Timothy R. Koves, Lauren Tauer, Meixia Pan, Xianlin Han, Jason K. Kim, Christopher B. Newgard, Deborah M. Muoio, Michael P. Czech
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112488- (2023)
Summary: Disruption of adipocyte de novo lipogenesis (DNL) by deletion of fatty acid synthase (FASN) in mice induces browning in inguinal white adipose tissue (iWAT). However, adipocyte FASN knockout (KO) increases acetyl-coenzyme A (CoA) and malonyl
Externí odkaz:
https://doaj.org/article/12bc2d6551c14f2b8d253e56cdc46fc0
Autor:
Søs Skovsø, Evgeniy Panzhinskiy, Jelena Kolic, Haoning Howard Cen, Derek A. Dionne, Xiao-Qing Dai, Rohit B. Sharma, Lynda Elghazi, Cara E. Ellis, Katharine Faulkner, Stephanie A. M. Marcil, Peter Overby, Nilou Noursadeghi, Daria Hutchinson, Xiaoke Hu, Hong Li, Honey Modi, Jennifer S. Wildi, J. Diego Botezelli, Hye Lim Noh, Sujin Suk, Brian Gablaski, Austin Bautista, Ryekjang Kim, Corentin Cras-Méneur, Stephane Flibotte, Sunita Sinha, Dan S. Luciani, Corey Nislow, Elizabeth J. Rideout, Eric N. Cytrynbaum, Jason K. Kim, Ernesto Bernal-Mizrachi, Laura C. Alonso, Patrick E. MacDonald, James D. Johnson
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-22 (2022)
Insulin receptor protein is present in pancreatic β-cells, but the consequences of β-cell insulin resistance are incompletely understood. Here the authors use a combination of mouse studies and mathematical modelling to show that loss of beta-cell
Externí odkaz:
https://doaj.org/article/34fcff15f65143fa8ca0bab84b4cd93e
Autor:
Emmanouela Tsagkaraki, Sarah M. Nicoloro, Tiffany DeSouza, Javier Solivan-Rivera, Anand Desai, Lawrence M. Lifshitz, Yuefei Shen, Mark Kelly, Adilson Guilherme, Felipe Henriques, Nadia Amrani, Raed Ibraheim, Tomas C. Rodriguez, Kevin Luk, Stacy Maitland, Randall H. Friedline, Lauren Tauer, Xiaodi Hu, Jason K. Kim, Scot A. Wolfe, Erik J. Sontheimer, Silvia Corvera, Michael P. Czech
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Worldwide pandemics of obesity and diabetes prompt an urgent need for new approaches to their prevention and cure. Here the authors present a CRISPR-based strategy that enhances the therapeutic potential of human adipocytes when implanted in obese mi
Externí odkaz:
https://doaj.org/article/9db95209ec9c4296b7f96552abbf9db0
Autor:
Kalpana D. Acharya, Randall H. Friedline, Doyle V. Ward, Madeline E. Graham, Lauren Tauer, Doris Zheng, Xiaodi Hu, Willem M. de Vos, Beth A. McCormick, Jason K. Kim, Marc J. Tetel
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Estrogens protect against weight gain and metabolic disruption in women and female rodents. Aberrations in the gut microbiota composition are linked to obesity and metabolic disorders. Furthermore, estrogen-mediated protection against diet-induced me
Externí odkaz:
https://doaj.org/article/165287e9809e4a129a026af32e7dca2d
Autor:
Suchaorn Saengnipanthkul, Hye Lim Noh, Randall H. Friedline, Sujin Suk, Stephanie Choi, Nicholas K. Acosta, Duy A. Tran, Xiaodi Hu, Kunikazu Inashima, Allison M. Kim, Ki Won Lee, Jason K. Kim
Publikováno v:
Physiological Reports, Vol 9, Iss 6, Pp n/a-n/a (2021)
Abstract Increasing evidence shows a potential link between the perinatal nutrient environment and metabolic outcome in offspring. Here, we investigated the effects of maternal feeding of a high‐fat diet (HFD) during the perinatal period on hepatic
Externí odkaz:
https://doaj.org/article/7e3e901846094972a3f3f8a6e838bb42