Epigenetic Silencing of PTEN and Epi-Transcriptional Silencing of MDM2 Underlied Progression to Secondary Acute Myeloid Leukemia in Myelodysplastic Syndrome Treated with Hypomethylating Agents

Autor: Paul Lee, Rita Yim, Kai-Kei Miu, Sin-Hang Fung, Jason Jinyue Liao, Zhangting Wang, Jun Li, Yammy Yung, Hiu-Tung Chu, Pui-Kwan Yip, Emily Lee, Eric Tse, Yok-Lam Kwong, Harinder Gill

Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 10, p 5670 (2022)

In myelodysplastic syndrome (MDS), resistance to hypomethylating agents (HMA) portends a poor prognosis, underscoring the importance of understanding the molecular mechanisms leading to HMA-resistance. In this study, P39 and Kasumi-1 cells and their

Externí odkaz: https://doaj.org/article/242f13a9adea43ac815fe4e8db79d843

Epigenetic Silencing of PTEN and Epi-Transcriptional Silencing of MDM2 Underlied Progression to Secondary Acute Myeloid Leukemia in Myelodysplastic Syndrome Treated with Hypomethylating Agents.

Autor: Lee, Paul¹ (AUTHOR) pl85@hku.hk, Yim, Rita¹ (AUTHOR) ritayim@hku.hk, Miu, Kai-Kei² (AUTHOR) kelvinmiu@cuhk.edu.hk, Fung, Sin-Hang² (AUTHOR) shfung@link.cuhk.edu.hk, Liao, Jason Jinyue³ (AUTHOR) liaojinyue@cuhk.edu.hk, Wang, Zhangting² (AUTHOR) wangzhangting@cuhk.edu.hk, Li, Jun⁴ (AUTHOR) jun.li@cityu.edu.hk, Yung, Yammy¹ (AUTHOR) u3558354@hku.hk, Chu, Hiu-Tung¹ (AUTHOR) u3557654@hku.hk, Yip, Pui-Kwan¹ (AUTHOR) u3557642@hku.hk, Lee, Emily¹ (AUTHOR) emilylmy@connect.hku.hk, Tse, Eric¹ (AUTHOR) ewctse@hku.hk, Kwong, Yok-Lam¹ (AUTHOR) ylkwong@hku.hk, Gill, Harinder¹ (AUTHOR) gillhsh@hku.hk

Publikováno v: International Journal of Molecular Sciences. May2022, Vol. 23 Issue 10, p5670-5670. 15p.