Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Jason J. Yuen"'
Autor:
Robin D. Clugston, Jason J. Yuen, Yunying Hu, Nada A. Abumrad, Paul D. Berk, Ira J. Goldberg, William S. Blaner, Li-Shin Huang
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 2, Pp 239-246 (2014)
CD36 is a scavenger receptor with multiple ligands and cellular functions, including facilitating cellular uptake of free fatty acids (FFAs). Chronic alcohol consumption increases hepatic CD36 expression, leading to the hypothesis that this promotes
Externí odkaz:
https://doaj.org/article/4a5bd38646eb437fb24884429b3e815a
Autor:
Gene P. Ables, Kryscilla Jian Zhang Yang, Silke Vogel, Antonio Hernandez-Ono, Shuiqing Yu, Jason J. Yuen, Susan Birtles, Linda K. Buckett, Andrew V. Turnbull, Ira J. Goldberg, William S. Blaner, Li-Shin Huang, Henry N. Ginsberg
Publikováno v:
Journal of Lipid Research, Vol 53, Iss 11, Pp 2364-2379 (2012)
Acyl CoA:diacylglycerol acyltransferase (DGAT) 1 catalyzes the final step of triglyceride (TG) synthesis. We show that acute administration of a DGAT1 inhibitor (DGAT1i) by oral gavage or genetic deletion of intestinal Dgat1 (intestine-Dgat1−/−)
Externí odkaz:
https://doaj.org/article/ef0ae0cad15247f89a3efeb1b1b8818c
Autor:
Robin D. Clugston, Hongfeng Jiang, Man Xia Lee, Roseann Piantedosi, Jason J. Yuen, Rajasekhar Ramakrishnan, Michael J. Lewis, Max E. Gottesman, Li-Shin Huang, Ira J. Goldberg, Paul D. Berk, William S. Blaner
Publikováno v:
Journal of Lipid Research, Vol 52, Iss 11, Pp 2021-2031 (2011)
Chronic alcohol consumption is associated with fatty liver disease in mammals. The object of this study was to gain an understanding of dysregulated lipid metabolism in alcohol-fed C57BL/6 mice using a targeted lipidomic approach. Liquid chromatograp
Externí odkaz:
https://doaj.org/article/a00929c172bd447894322b4e9117a329
Autor:
Judith Storch, Jun B. Feranil, Jenny Libien, Marcin Golczak, Wojciech Krezel, Kryscilla Jian Zhang Yang, Shmarakov Io, Hongfeng Jiang, Pierre-Jacques Brun, Seung-Ah Lee, William S. Blaner, Josie A. Silvaroli, Xueting Li, Jason J. Yuen, Rudolph L. Leibel, Atreju I. Lackey
Publikováno v:
Science Advances
Science Advances, 2020, 6 (11), pp.32195347. ⟨10.1126/sciadv.aay8937⟩
Science Advances, 2020, 6 (11), pp.32195347. ⟨10.1126/sciadv.aay8937⟩
Retinol-binding protein 2 (RBP2) binds 2-monoacylglycerols affecting their intestinal levels and enteroendocrine responses.
Expressed in the small intestine, retinol-binding protein 2 (RBP2) facilitates dietary retinoid absorption. Rbp2-deficien
Expressed in the small intestine, retinol-binding protein 2 (RBP2) facilitates dietary retinoid absorption. Rbp2-deficien
Autor:
Caleb T. Epps, Seung-Ah Lee, Ira J. Goldberg, Amit Saha, Sarahjean Kerolle, Yungying Hu, Li-Shin Huang, Robin D. Clugston, Jason J. Yuen, Hongfeng Jiang, William S. Blaner, Michael J. Trites
Publikováno v:
Alcoholism, Clinical and Experimental Research
Background The first stage of alcoholic liver disease is hepatic steatosis. While alcohol is known to profoundly impact hepatic lipid metabolism, gaps in our knowledge remain regarding the mechanisms leading to alcohol‐induced hepatic triglyceride
Publikováno v:
Hepatology. 64:1534-1546
There is considerable evidence that both retinoids and retinol-binding protein 4 (RBP4) contribute to the development of liver disease. To understand the basis for this, we generated and studied transgenic mice that express human RBP4 (hRBP4) specifi
Autor:
Sandhya Sriram, Kosuke Takeda, Wee Kiat Ong, Jayakumar Perumal, Seung-Ah Lee, Malini Olivo, Sue-Anne Toh, Jason J. Yuen, Shawn Hoon, Betty Tan, Weiping Han, Chia Rou Yeo, Vivek Tanavde, Xin Hui Derryn Chan, Shigeki Sugii, Kien Voon Kong, Jimmy Bok Yan So, Candida Vaz, Madhur Agrawal, Asim Shabbir, William S. Blaner, Hongfeng Jiang
Publikováno v:
Diabetes. 65:1164-1178
Increased visceral fat, rather than subcutaneous fat, during the onset of obesity is associated with a higher risk of developing metabolic diseases. The inherent adipogenic properties of human adipose-derived stem cells (ASCs) from visceral depots ar
Autor:
Seung-Ah Lee, Robert W. Curley, Sureshbabu Narayanasamy, Hongfeng Jiang, William S. Blaner, Jason J. Yuen, Earl H. Harrison, Cynthia X. Wang
Publikováno v:
Archives of Biochemistry and Biophysics. 572:2-10
β-Apo-carotenoids, including β-apo-13-carotenone and β-apo-14'-carotenal, are potent retinoic acid receptor (RAR) antagonists in transactivation assays. We asked how these influence RAR-dependent processes in living cells. Initially, we explored t
Autor:
Seung-Ah Lee, Jason J. Yuen, Robert W. Curley, Ira J. Goldberg, Hongfeng Jiang, Chad M. Trent, William S. Blaner, Earl H. Harrison, Sureshbabu Narayanasamy, Mathew S. Maurer
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 307:H1675-H1684
Dietary carotenoids like β-carotene are converted within the body either to retinoid, via β-carotene-15,15′-dioxygenase (BCO1), or to β-apo-carotenoids, via β-carotene-9′,10′-oxygenase 2. Some β-apo-carotenoids are potent antagonists of re
Autor:
Koichi Shudo, William S. Blaner, Bhaskar C. Das, Hiroyuki Kagechika, Pierre-Jacques Brun, Ambar Grijalva, Richard Rausch, Elizabeth Watson, Rudolph L. Leibel, Jason J. Yuen
Publikováno v:
The FASEB Journal. 29:671-683
Retinoic acid signaling is required for maintaining a range of cellular processes, including cell differentiation, proliferation, and apoptosis. We investigated the actions of all-trans-retinoic acid (atRA) signaling in pancreatic β-cells of adult m