Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Jason J. Shiers"'
Autor:
Andrew Leishman, Wayne Paes, Emma Sparrow, Ana Ribeiro, Michael Cundell, Milos Aleksic, Michael P. Pinggera, Jessica Sette, Kate Anderton, Nicola Ternette, Juliet Morgan, Jason J. Shiers, Martin Quibell, Peter I. Joyce
Publikováno v:
Cancer Research. 83:3467-3467
Immune checkpoint inhibitors (ICI) have changed the cancer treatment paradigm, yet significant unmet need remains. Clinical data shows that increasing antigen presentation diversity, genomic instability, tumor mutational burden and HLA diversity, as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d5bd330663d41c67cee96c805d7ad09
https://doi.org/10.1158/1538-7445.am2023-3467
https://doi.org/10.1158/1538-7445.am2023-3467
Autor:
Earl, Clarke, Christopher I, Jarvis, Maria B, Goncalves, S Barret, Kalindjian, David R, Adams, Jane T, Brown, Jason J, Shiers, David M A, Taddei, Elodie, Ravier, Stephanie, Barlow, Iain, Miller, Vanessa, Smith, Alan D, Borthwick, Jonathan P T, Corcoran
Publikováno v:
Bioorganic & Medicinal Chemistry
Graphical abstract
A ligand-based virtual screening exercise examining likely bioactive conformations of AM 580 (2) and AGN 193836 (3) was used to identify the novel, less lipophilic RARα agonist 4-(3,5-dichloro-4-ethoxybenzamido)benzoic acid 5
A ligand-based virtual screening exercise examining likely bioactive conformations of AM 580 (2) and AGN 193836 (3) was used to identify the novel, less lipophilic RARα agonist 4-(3,5-dichloro-4-ethoxybenzamido)benzoic acid 5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a651db96aeac6253440f0f177d2dd404
https://pubmed.ncbi.nlm.nih.gov/29288071
https://pubmed.ncbi.nlm.nih.gov/29288071
Autor:
Jerome F. Hayes, Michael Shipman, Sabitur Rahman, Gildas Prie, Natacha Prevost, Cyril Montagne, Jason J. Shiers
Publikováno v:
Tetrahedron. 62:8447-8457
2-Methyleneaziridinyl anions can be produced by selective deprotonation of the parent aziridine at C-3 using sec-BuLi/TMEDA. Subsequent reaction with a wide variety of electrophiles including MeI, ICH2CH2CH2CH2Cl, PhCH2Br, allyl bromide, Me3SiCl, Bu3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69b220ebdbf739630293126f3e2f5edc
https://doi.org/10.1016/j.tet.2006.06.083
https://doi.org/10.1016/j.tet.2006.06.083
Publikováno v:
ChemInform. 39
Ring opening of indole functionalised methyleneaziridines (3a-c, 7) with alcohols in the presence of boron trifluoride etherate leads to the formation of 1,1-disubstituted tetrahydro-beta-carbolines in moderate to good yields (37-83%). (c) 2008 Elsev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f758114433a169e37a4dcacdfbe65db9
https://doi.org/10.1002/chin.200835141
https://doi.org/10.1002/chin.200835141
Publikováno v:
ChemInform. 38
2-Methyleneaziridines can be transformed into 5,5′-disubstituted hydantoins in moderate to good yield (48–75%) via a ‘one-pot’ process that brings together up to six components in an orchestrated way.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e0a6e34cce75cd0bdba65a6acb078f5
https://doi.org/10.1002/chin.200714141
https://doi.org/10.1002/chin.200714141
Publikováno v:
Journal of the American Chemical Society. 126:6868-6869
Intramolecular nucleophilic substitution of the C-Br bond of (E)- and (Z)-2-bromobut-2-enylamines by the pendant nitrogen atom leads to 2-ethyleneaziridines by way of stereochemical inversion at the vinylic carbon atom. The stereochemistry of the pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6462f768bcf8171e71c57f4be595e8d2
https://doi.org/10.1021/ja0482684
https://doi.org/10.1021/ja0482684
Publikováno v:
Chemical Communications; Jan2006, Vol. 2006 Issue 6, p649-651, 3p
Autor:
Qin T; Sygnature Discovery Ltd., BioCity, Pennyfoot Street, Nottingham, United Kingdom. Electronic address: t.qin@sygnaturediscovery.com., Hernandez SER; Sygnature Discovery Ltd., BioCity, Pennyfoot Street, Nottingham, United Kingdom., Shiers J; Sygnature Discovery Ltd., BioCity, Pennyfoot Street, Nottingham, United Kingdom., Crittall M; Sygnature Discovery Ltd., BioCity, Pennyfoot Street, Nottingham, United Kingdom., Novak A; Sygnature Discovery Ltd., BioCity, Pennyfoot Street, Nottingham, United Kingdom., Smith CS; Sygnature Discovery Ltd., BioCity, Pennyfoot Street, Nottingham, United Kingdom.
Publikováno v:
SLAS technology [SLAS Technol] 2024 Jun; Vol. 29 (3), pp. 100143. Date of Electronic Publication: 2024 May 11.
Autor:
Qin T; Sygnature Discovery Ltd., BioCity, Pennyfoot Street, Nottingham, United Kingdom. Electronic address: t.qin@sygnaturediscovery.com., Grabski M; Sygnature Discovery Ltd., BioCity, Pennyfoot Street, Nottingham, United Kingdom., Fitzpatrick D; Antipodes Scientific Ltd., 41 College Ride, Bagshot, United Kingdom., Salsbury J; Sygnature Discovery Ltd., BioCity, Pennyfoot Street, Nottingham, United Kingdom., Allford T; Sygnature Discovery Ltd., BioCity, Pennyfoot Street, Nottingham, United Kingdom., Pole J; Sygnature Discovery Ltd., BioCity, Pennyfoot Street, Nottingham, United Kingdom., Novak A; Sygnature Discovery Ltd., BioCity, Pennyfoot Street, Nottingham, United Kingdom., Shiers J; Sygnature Discovery Ltd., BioCity, Pennyfoot Street, Nottingham, United Kingdom., Smith CS; Sygnature Discovery Ltd., BioCity, Pennyfoot Street, Nottingham, United Kingdom.
Publikováno v:
SLAS technology [SLAS Technol] 2022 Jun; Vol. 27 (3), pp. 204-208. Date of Electronic Publication: 2021 Dec 07.