Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Jason J. Reddick"'
Autor:
Grant Hardesty, Jennifer S. Doyle, Brittany E. Kiel, Natalie E. Hage, Amy L. Quattlebaum, Sherona Sirkisoon, Jason J. Reddick, Rejwi Acharya Dahal, William T. Booth, Sydney L. H. Adams, Victoria G. Meadows, Suzette N. Mills
Publikováno v:
Biochemistry. 56:5698-5711
The genome of Bacillus subtilis strain 168 contains the mother cell metabolic gene (mmg) operon that encodes homologues from the methylcitric acid cycle. We showed that the three genes, mmgDE and yqiQ(mmgF), provide three of the five steps of the met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e5e23920876aaafa3bc63e6a2bc3b2e
https://doi.org/10.1021/acs.biochem.7b00778
https://doi.org/10.1021/acs.biochem.7b00778
Autor:
Jayme Williams, Jason J. Reddick
Publikováno v:
Biotechnology Letters. 30:1045-1050
Early in sporulation, the mother cell compartment of Bacillus subtilis transcribes the mother cell metabolic gene (mmg) operon. The gene mmgA was assigned by other workers using sequence homology as an acetyl-CoA acetyltransferase [E.C. 2.3.1.9]. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d9ba6f7eda8aae1697b1e08a1d6a458
https://doi.org/10.1007/s10529-008-9642-4
https://doi.org/10.1007/s10529-008-9642-4
Publikováno v:
Biochemical and Biophysical Research Communications. 358:363-367
As part of the pksX gene cluster of Bacillus subtilis strain 168, pksS has been preliminarily annotated as a cytochrome P450 homolog that hydroxylates the polyketide product of this cluster, which was recently shown to be involved in the biosynthesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::807d1019c5bc6c085a0e053c5cd31dd5
https://doi.org/10.1016/j.bbrc.2007.04.151
https://doi.org/10.1016/j.bbrc.2007.04.151
Publikováno v:
Organic Letters. 5:1967-1970
[reaction: see text] The relative rates of Michael additions of 2'-(phenethyl)thiol to representative vinyl sulfonyl Michael acceptors were measured. The dependence of the reactivity of the Michael acceptor on the nature of the sulfonyl R substituent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d77941fc3aa83415680a284dca69497c
https://doi.org/10.1021/ol034555l
https://doi.org/10.1021/ol034555l
Autor:
Jonathan S. Melnick, Jian-ming Lee, Jason J. Reddick, Soumitra Saha, Tadhg P. Begley, John B. Perkins
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:2245-2248
The mechanism of bacimethrin (2) toxicity has been determined. This compound is converted to 2'-methoxy-thiamin pyrophosphate (10) by the thiamin biosynthetic enzymes. Of the seven thiamin pyrophosphate utilizing enzymes in Escherichia coli, 2'-metho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::924272bbd371001f81f29ee4fac779b4
https://doi.org/10.1016/s0960-894x(01)00373-0
https://doi.org/10.1016/s0960-894x(01)00373-0
Publikováno v:
Biochemistry. 40:10095-10102
Thiamin phosphate synthase catalyzes the coupling of 4-methyl-5-(beta-hydroxyethyl)thiazole phosphate (Thz-P) and 4-amino-5-(hydroxymethyl)-2-methylpyrimidine pyrophosphate (HMP-PP) to give thiamin phosphate. In this paper, we demonstrate that 4-amin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eee9dc29e8ade30cd96e56e3745f50c8
https://doi.org/10.1021/bi010267q
https://doi.org/10.1021/bi010267q
Autor:
Hsiu-Ju Chiu, Jason J. Reddick, Jun Xi, Nino Campobasso, Van Loon Ap, Diana M. Downs, Fred W. McLafferty, Cynthia Kinsland, Sean V. Taylor, Steven E. Ealick, Tadhg P. Begley
Publikováno v:
Archives of Microbiology. 171:293-300
Twelve genes involved in thiamin biosynthesis in prokaryotes have been identified and overexpressed. Of these, six are required for the thiazole biosynthesis (thiFSGH, thil, and dxs), one is involved in the pyrimidine biosynthesis (thiC), one is requ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02538dec4d734966eec832f6ae7c259a
https://doi.org/10.1007/s002030050713
https://doi.org/10.1007/s002030050713
Autor:
Todd Christian, Tadhg P. Begley, Cynthia Kinsland, Jason J. Reddick, Robb Nicewonger, Malcolm E. Winkler, Diana M. Downs
Publikováno v:
Tetrahedron. 54:15983-15991
The overexpression, purification and characterization of 4-amino-5-hydroxymethyl-2-methylpyrimidine kinase (HMP kinase) and 4-amino-5-hydroxymethyl-2-methylpyrimidine monophosphate kinase (HMP-P kinase) are described. Surprisingly HMP-P kinase also s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9253f12b724d2ba48d89fde4e19b3e6
https://doi.org/10.1016/s0040-4020(98)01006-0
https://doi.org/10.1016/s0040-4020(98)01006-0
Autor:
Diana M. Downs, Robb Nicewonger, Todd Christian, Jason J. Reddick, Malcolm E. Winkler, Cynthia Kinsland, Tadhg P. Begley
Publikováno v:
ChemInform. 30
The overexpression, purification and characterization of 4-amino-5-hydroxymethyl-2-methylpyrimidine kinase (HMP kinase) and 4-amino-5-hydroxymethyl-2-methylpyrimidine monophosphate kinase (HMP-P kinase) are described. Surprisingly HMP-P kinase also s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9a7b041a9097dd7b57f43310a04206f
https://doi.org/10.1002/chin.199917266
https://doi.org/10.1002/chin.199917266
Publikováno v:
Bioorganicmedicinal chemistry letters. 13(22)
Thiamin pyrophosphate was synthesized in 71% yield, on a multi-milligram scale, using overexpressed thiazole kinase, pyrimidine kinase, thiamin phosphate synthase, and thiamin phosphate kinase. This provides a facile route to isotopically labeled thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2399942243d50e7958f10ef28dbc2b31
https://pubmed.ncbi.nlm.nih.gov/14592524
https://pubmed.ncbi.nlm.nih.gov/14592524