Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Jason J. Marineau"'
Autor:
Ashraf Wilsily, Robert Zahler, Nan Ke, Claudio Chuaqui, Michael J. Bradley, Jason J. Marineau, Goran Malojčić, Stephane Ciblat, Anneli Savinainen, Darby Schmidt, Nigel J. Waters, Kristin B. Hamman, Sydney Alnemy, Stephanie Roy, Dana K. Winter, Anzhelika Kabro, Kenneth Matthew Whitmore, Shanhu Hu, Janessa Mihalich
Publikováno v:
Journal of medicinal chemistry. 65(2)
CDK7 has emerged as an exciting target in oncology due to its roles in two important processes that are misregulated in cancer cells: cell cycle and transcription. This report describes the discovery of SY-5609, a highly potent (sub-nM CDK7 Kd) and s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a002487d311de55b839be03137541dfe
https://pubmed.ncbi.nlm.nih.gov/34726887
https://pubmed.ncbi.nlm.nih.gov/34726887
Autor:
Nan Ke, Yoon Jong Choi, David A. Orlando, Emmanuelle di Tomaso, Kevin Sprott, Christian Fritz, Shanhu Hu, Michael J. Bradley, John Carulli, Darby Schmidt, Eric R. Olson, Stephane Ciblat, Nisha Rajagopal, Jason J. Marineau, J. Graeme Hodgson, Dana K. Winter, Anzhelika Kabro, Yixuan Ren, Kristin B. Hamman, Sydney Alnemy, Liv Johannessen
Publikováno v:
Cancer Research. 79:3479-3491
Recent studies suggest that targeting transcriptional machinery can lead to potent and selective anticancer effects in cancers dependent on high and constant expression of certain transcription factors for growth and survival. Cyclin-dependent kinase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06450210654bdc8576936764e0d54305
https://doi.org/10.1158/0008-5472.can-19-0119
https://doi.org/10.1158/0008-5472.can-19-0119
Autor:
Goran Malojčić, Martine Brault, Ines H. Kaltheuner, Lewis C. Cantley, Patrick Deroy, Heeyoun Bunch, Shanhu Hu, Janet Iwasa, Robin D. Dowell, Michael J. Bradley, Christian Clavette, Limei Tao, Peter W. White, Matthias Geyer, Zachary C. Poss, William M. Old, Zachary L. Maas, Shraddha Nayak, Tim-Michael Decker, Christopher C. Ebmeier, Benjamin Erickson, Leah J. Damon, David Bentley, Jenna K. Rimel, Tomer M. Yaron, Jason J. Marineau, Jared L. Johnson, Kristin B. Hamman, Dylan J. Taatjes
Publikováno v:
Genes Dev
CDK7 associates with the 10-subunit TFIIH complex and regulates transcription by phosphorylating the C-terminal domain (CTD) of RNA polymerase II (RNAPII). Few additional CDK7 substrates are known. Here, using the covalent inhibitor SY-351 and quanti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec82b692d03b26dca0e48986e06f8ae7
https://pubmed.ncbi.nlm.nih.gov/33060135
https://pubmed.ncbi.nlm.nih.gov/33060135
Autor:
Nan Ke, Anneli Savinainen, Liv Johannessen, Shanhu Hu, Anthony D'Ippolito, Jason J. Marineau, Graeme Hodgson, Nisha Rajagopal, William C. Zamboni
Publikováno v:
Molecular Cancer Therapeutics. 18:C091-C091
Introduction: CDK7 is a key regulator of transcription and cell cycle progression and has been implicated in multiple tumor types driven by aberrant transcriptional control (e.g. MYC-, ESR1-activation) and/or aberrant cell cycle control (e.g. RB1, CC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::79a28d1ec1fd4b80cd93b795ff3f8265
https://doi.org/10.1158/1535-7163.targ-19-c091
https://doi.org/10.1158/1535-7163.targ-19-c091
Autor:
James E. Bradner, Dennis L. Buckley, Wei Zhang, Harry Fu, Michael R. McKeown, Jason J. Marineau, Stephen C. Blacklow, Yibo Huang, Xiang Xu, Asha Kadam, Zijuan Zhang, Daniel L. Shaw, Xiaofeng Zhang, Jun Qi, Shuai Liu
Publikováno v:
Journal of Medicinal Chemistry
BET bromodomain inhibition has contributed new insights into gene regulation and emerged as a promising therapeutic strategy in cancer. Structural analogy of early methyl-triazolo BET inhibitors has prompted a need for structurally dissimilar ligands
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d198a068cb5dd9f388147d6534d170e7
http://europepmc.org/articles/PMC4234447
http://europepmc.org/articles/PMC4234447
Autor:
Luis E. N. Quadri, Poornima Mohandas, Alberto Munoz, Jason J. Marineau, James E. Bradner, William B. Smith, Andrew S. Au, Michael P. D'Erasmo, Ryan P. Murelli
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:4035-4038
7,9-Diaryl-1,6,8-trioxaspiro[4.5]dec-3-en-2-ones are a recently described group of spirocyclic butenolides that can be generated rapidly and as a single diastereomer through a cascade process between γ-hydroxybutenolides and aromatic aldehydes. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a3b85098f158d0ba5ca58064861ab17
https://doi.org/10.1016/j.bmcl.2014.05.102
https://doi.org/10.1016/j.bmcl.2014.05.102
Autor:
Alex Kentsis, A. Thomas Look, James E. Bradner, Frederic Baleydier, Ruta Grebliunaite, Jon C. Aster, Huipin Yuan, Andrew P. Weng, Françoise Pflumio, Li Pan, Lynn VerPlank, Jason J. Marineau, Stephanie Norton, Richard W.J. Groen, Frank An, Jason Burbank, Benjamin Uzan, Constantine S. Mitsiades, Hanno Steen, Sandrine Poglio, Nicola Tolliday, Casie Reed, Elena Kozakewich, Paul A. Clemons, Alejandro Gutierrez
Publikováno v:
Journal of Clinical Investigation, 124(2), 644-55. The American Society for Clinical Investigation
Gutierrez, A, Pan, L, Groen, R W J, Baleydier, F, Kentsis, A, Marineau, J, Grebliunaite, R, Kozakewich, E, Reed, C, Pflumio, F, Poglio, S, Uzan, B, Clemons, P, VerPlank, L, An, F, Burbank, J, Norton, S, Tolliday, N, Steen, H, Weng, A P, Yuan, H, Bradner, J E, Mitsiades, C, Look, A T & Aster, J C 2014, ' Phenothiazines induce PP2A-mediated apoptosis in T cell acute lymphoblastic leukemia ', Journal of Clinical Investigation, vol. 124, no. 2, pp. 644-55 . https://doi.org/10.1172/JCI65093
Gutierrez, A, Pan, L, Groen, R W J, Baleydier, F, Kentsis, A, Marineau, J, Grebliunaite, R, Kozakewich, E, Reed, C, Pflumio, F, Poglio, S, Uzan, B, Clemons, P, VerPlank, L, An, F, Burbank, J, Norton, S, Tolliday, N, Steen, H, Weng, A P, Yuan, H, Bradner, J E, Mitsiades, C, Look, A T & Aster, J C 2014, ' Phenothiazines induce PP2A-mediated apoptosis in T cell acute lymphoblastic leukemia ', Journal of Clinical Investigation, vol. 124, no. 2, pp. 644-55 . https://doi.org/10.1172/JCI65093
T cell acute lymphoblastic leukemia (T-ALL) is an aggressive cancer that is frequently associated with activating mutations in NOTCH1 and dysregulation of MYC. Here, we performed 2 complementary screens to identify FDA-approved drugs and drug-like sm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42754d1bf080836a1fcd220ac6453f2e
https://doi.org/10.1172/jci65093
https://doi.org/10.1172/jci65093
Autor:
James E. Bradner, Jason J. Marineau, Peter B. Rahl, Alla A. Sigova, Matthew G. Guenther, Zi Peng Fan, Jakob Lovén, Lars Anders, Richard A. Young, William B. Smith, Tong Ihn Lee, Jun Qi
Publikováno v:
Nature Biotechnology. 32:92-96
A vast number of small-molecule ligands, including therapeutic drugs under development and in clinical use, elicit their effects by binding specific proteins associated with the genome. An ability to map the direct interactions of a chemical entity w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eabdd8ac57a9a9cff0be2874ef1d18c7
https://doi.org/10.1038/nbt.2776
https://doi.org/10.1038/nbt.2776
Autor:
Michael Xiang, Jason J. Marineau, Sarah R. Walker, Daniel L. Shaw, Traci M. Blonquist, Richard Stone, Haesook T. Kim, Vincent T. Ho, Suhu Liu, Robert J. Soiffer, Zachary T. Giaccone, Yasmin Kroll, Donna Neuberg, Lisa N. Heppler, David A. Frank, Melodi Anahtar, James E. Bradner, Michal Bar-Natan, Darwin Q. Ye, Patricia A. Toniolo, Nichole Jones, Claudio Hetz
Publikováno v:
Blood
Artículos CONICYT
CONICYT Chile
instacron:CONICYT
Artículos CONICYT
CONICYT Chile
instacron:CONICYT
The oncogenic transcription factor signal transducer and activator of transcription 3 (STAT3) is frequently activated inappropriately in a wide range of hematological and solid cancers, but clinically available therapies targeting STAT3 are lacking.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8349c064b881a05ac4767213f8968b6e
Publikováno v:
Analytical chemistry. 87(12)
Analysis of complex mixtures of proteins by hydrogen exchange (HX) mass spectrometry (MS) is limited by one's ability to resolve the protein(s) of interest from the proteins that are not of interest. One strategy for overcoming this problem is to tag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f08f3a73f477f358342b642733f7648
https://pubmed.ncbi.nlm.nih.gov/26023704
https://pubmed.ncbi.nlm.nih.gov/26023704