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pro vyhledávání: '"Jason J. Kuo"'
Publikováno v:
The Journal of Physiology. 580:507-522
Throughout the mammalian spinal cord, interneurones have been shown to exhibit distinct firing patterns in response to a step of injected current. In this study of ventral horn interneurones in a thick slice preparation of the lumbar cord of 11–19-
Publikováno v:
The Journal of Physiology. 574:819-834
Spinal motoneurons, like many neurons, respond with repetitive spiking to sustained inputs. The afterhyperpolarization (AHP) that follows each spike, however, decays relatively slowly in motoneurons. The slow depolarization during this decay should a
Publikováno v:
The Journal of Physiology. 563:843-854
Mutations in the enzyme superoxide dismutase 1 (SOD1) initiate a progressive motoneurone degeneration in amyotrophic lateral sclerosis (ALS). Transgenic mice overexpressing this mutation develop a similar progressive motoneurone degeneration. In spin
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 82:549-555
Motoneurons have extensive dendritic trees that receive the numerous inputs required to produce movement. These dendrites are highly active, containing voltage-sensitive channels that generate persistent inward currents (PICs) that can enhance synapt
Publikováno v:
Journal of Neurophysiology. 90:3617-3624
Synaptic integration in vivo often involves activation of many afferent inputs whose firing patterns modulate over time. In spinal motoneurons, sustained excitatory inputs undergo enormous enhancement due to persistent inward currents (PICs) that are
Autor:
Alfons B.A. Kroese, Teepu Siddique, Peter R. Bär, Martijn Schonewille, Ronggen Fu, Annet N. A. Schults, Charles J. Heckman, Roberta Anelli, Jason J. Kuo
Publikováno v:
Journal of Neurophysiology, 91(1), 571-575. AMER PHYSIOLOGICAL SOC
ALS (amyotrophic lateral sclerosis) is an adult-onset and deadly neurodegenerative disease characterized by a progressive and selective loss of motoneurons. Transgenic mice overexpressing a mutated human gene (G93A) coding for the enzyme SOD1 (Cu/Zn
Publikováno v:
Journal of neurophysiology. 89(1)
The extensive dendritic tree of the adult spinal motoneuron generates a powerful persistent inward current (PIC). We investigated how this dendritic PIC influenced conversion of synaptic input to rhythmic firing. A linearly increasing, predominantly
Autor:
Chiang CF; Department of Economics, National Taiwan University, Taiwan. Electronic address: chunfang@ntu.edu.tw., Kuo J; Department of Political Science, National Taiwan University, Taiwan. Electronic address: jasonkuo@ntu.edu.tw., Liu JT; Department of Economics, National Taiwan University, Taiwan. Electronic address: liujt@ntu.edu.tw.
Publikováno v:
Social science & medicine (1982) [Soc Sci Med] 2022 Dec; Vol. 314, pp. 115403. Date of Electronic Publication: 2022 Oct 05.