Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Jason J. Holt"'
Autor:
Anatoliy S. Bushnev, Mark T. Baillie, Jason J. Holt, David S Menaldino, Alfred H. Merrill Jr., Dennis C. Liotta
Publikováno v:
ARKIVOC, Vol 2010, Iss 8, Pp 263-277 (2010)
Externí odkaz:
https://doaj.org/article/9e02da575f2e494a9beae5915b1c7b19
Autor:
G. Prabhakar Reddy, Randy B. Howard, Richard F. Arrendale, David S. Menaldino, Sarah T. Pruett, Manohar Saindane, Dennis C. Liotta, Mark T. Baillie, Jason J. Holt, Deborah G. Culver, John A. Petros, Eric J. Miller, Michael G. Natchus, Taylor J. Evers, Suzanne G. Mays
Publikováno v:
ACS Medicinal Chemistry Letters. 7:537-542
The orally bioavailable 1-deoxy-sphingosine analog, Enigmol, has demonstrated anticancer activity in numerous in vivo settings. However, as no Enigmol analog with enhanced potency in vitro has been identified, a new strategy to improve efficacy in vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5f8cc417011a9fe835509db03dfa969
https://doi.org/10.1021/acsmedchemlett.6b00113
https://doi.org/10.1021/acsmedchemlett.6b00113
Autor:
Jason J. Holt, John A. Petros, Anatoliy S. Bushnev, David S. Menaldino, Richard F. Arrendale, Lanny S. Liebeskind, Taylor J. Evers, Deborah G. Culver, G. Prabhakar Reddy, Suzanne G. Mays, Dennis C. Liotta, Mark T. Baillie, Randy B. Howard, Michael G. Natchus, Harsha Ramaraju, Ethel C. Garnier-Amblard
Publikováno v:
ACS Medicinal Chemistry Letters. 2:438-443
Enigmol is a synthetic, orally active 1-deoxysphingoid base analogue that has demonstrated promising activity against prostate cancer. In these studies, the pharmacologic roles of stereochemistry and N-methylation in the structure of enigmols were ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73d5ee2a7ea75912e9db3c96fd6717af
https://doi.org/10.1021/ml2000164
https://doi.org/10.1021/ml2000164
Autor:
Thomas J. Raub, M. Claire Bartlett, Tip W. Loo, Jason J. Holt, Michael R. Detty, Michael K. Gannon, Stephanie M. Bennett, Gregory Tombline, David M. Clarke, J. William Higgins, Bryan Wetzel, Geri A. Sawada
Publikováno v:
Journal of Medicinal Chemistry. 52:3328-3341
We have examined 46 tetramethylrosamine/rhodamine derivatives with structural diversity in the heteroatom of the xanthylium core, the amino substituents of the 3- and 6-positions, and the alkyl, aryl, or heteroaryl group at the 9-substituent. These c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f30a95b93a7a01c466e6dbeb74f94748
https://doi.org/10.1021/jm900253g
https://doi.org/10.1021/jm900253g
Autor:
Brandon D. Calitree, Michael R. Detty, Michael K. Gannon, Jochen Autschbach, David J. Donnelly, Cara L. Nygren, Jason J. Holt, Dinesh K. Sukumaran
Publikováno v:
Organometallics. 26:6248-6257
The first tellurium-containing analogues of the rosamine and rhodamine dyes were prepared by the addition of Grignard or organolithium reagents to telluroxanthone precursors. The 125Te spectra of both the dyes and the telluroxanthone precursors are r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00e3eb3f10c18cae10ec39ee6d64ffb2
https://doi.org/10.1021/om700846m
https://doi.org/10.1021/om700846m
Publikováno v:
The Journal of Organic Chemistry. 72:2690-2693
9-formyljulolidine was oxidized via a microwave-assisted Willgerodt-Kindler reaction to the N-piperidine or N-morpholine julolidine-9-thioamide. 9-formyl-1,1,7,7-tetramethyljulolidine gave the corresponding N-piperidine tetramethyljulolidine-9-thioam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3ac2ae536249238b78c2077ad4d46e3
https://doi.org/10.1021/jo070086f
https://doi.org/10.1021/jo070086f
Autor:
Gregory Tombline, Jason J. Holt, Michael R. Detty, Michael K. Gannon, Mao Ye, Youngjae You, Cara L. Nygren, David J. Donnelly
Publikováno v:
Biochemistry. 45:8034-8047
The multidrug resistance efflux pump P-glycoprotein (Pgp) couples drug export to ATP binding and hydrolysis. Details regarding drug trajectory, as well as the molecular basis for coupling, remain unknown. Nearly all drugs exported by Pgp have been as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbe7f1f996d4733cf3845542ff4d96b4
https://doi.org/10.1021/bi0603470
https://doi.org/10.1021/bi0603470
Publikováno v:
Organometallics. 24:3807-3810
The electrophilic cyclization of N,N-diethyl 4-N,N-(dimethylamino)-2-(3-N,N-dimethyldimethylaminophenylchalcogeno)benzamides 7 with POCl3 and triethylamine in CH2Cl2 or with POCl3 in acetonitrile gave excellent yields (77−97% in CH2Cl2, 73−77% in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::94a93d945bc929eaf9b591b2eb4f76ca
https://doi.org/10.1021/om050225o
https://doi.org/10.1021/om050225o
Autor:
Jason J. Holt, Esmeralda V. S. Meyer, Deborah G. Culver, Mark T. Ballie, G. Prabhakar Reddy, Dennis C. Liotta, Kathryn R. Girard, David S. Menaldino, Randy B. Howard, Anatoliy S. Bushnev, Taylor J. Evers, Stacey A. Lapp, Mary R. Galinski, Richard F. Arrendale, Michael G. Natchus
Publikováno v:
ACS medicinal chemistry letters. 3(1)
Plasmodium-infected erythrocytes have been shown to employ sphingolipids from both endogenous metabolism as well as existing host pools. Therapeutic agents that limit these supplies have thus emerged as intriguing, mechanistically distinct putative t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a1384c7cb49dd55c2bb0f648ba72068
https://pubmed.ncbi.nlm.nih.gov/24900369
https://pubmed.ncbi.nlm.nih.gov/24900369
Autor:
Jason J. Holt, Thomas J. Raub, Bryan Wetzel, Geri A. Sawada, Gregory Tombline, Michael R. Detty, Michael K. Gannon, David J. Donnelly
Publikováno v:
Biochemistry. 47(10)
The multidrug efflux pump P-glycoprotein (Pgp) couples drug transport to ATP hydrolysis. Previously, using a synthetic library of tetramethylrosamine ( TMR) analogues, we observed significant variation in ATPase stimulation ( V m (D)). Concentrations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::526c3151d2258cbac69c4fc302a40b96
https://pubmed.ncbi.nlm.nih.gov/18275155
https://pubmed.ncbi.nlm.nih.gov/18275155