Zobrazeno 1 - 10
of 144
pro vyhledávání: '"Jason J McDougall"'
Publikováno v:
PLoS ONE, Vol 13, Iss 2, p e0191906 (2018)
Avocado/soybean unsaponifiables such as Arthrocen have been reported to reduce cartilage catabolism and chondrocytic synthesis of inflammatory mediators associated with osteoarthritis (OA). While there is some clinical evidence that avocado/soybean u
Externí odkaz:
https://doaj.org/article/b649a8a253e341e387df0d4a55c54134
Publikováno v:
Orthopedic Research and Reviews, Vol 2011, Iss default, Pp 1-8 (2011)
Niklas Schuelert, Fiona A Russell, Jason J McDougallDepartment of Physiology and Pharmacology, University of Calgary, Calgary, AB, CanadaAbstract: Osteoarthritis (OA) is a common disease that affects millions of people worldwide. As there is no cure
Externí odkaz:
https://doaj.org/article/67f70fc20db34824a4ccd47a5a03730d
Publikováno v:
Canadian Journal of Pain, Vol 7, Iss 2 (2023)
Externí odkaz:
https://doaj.org/article/91b19c8dad82442fb2b20ed5a2b9b100
Autor:
Holly T. Philpott, Jason J. McDougall
Publikováno v:
Arthritis Research & Therapy, Vol 22, Iss 1, Pp 1-9 (2020)
Abstract Background Endocannabinoids are showing great promise as effective mediators for controlling joint inflammation and pain. One strategy that could be harnessed to promote endogenous cannabinoid function is to inhibit the enzymatic break down
Externí odkaz:
https://doaj.org/article/5f03ea48607044cda9bb2875fb174bde
Autor:
Jason J. McDougall, Allison R. Reid
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Joint pain is a complex phenomenon that involves multiple endogenous mediators and pathophysiological events. In addition to nociceptive and inflammatory pain, some patients report neuropathic-like pain symptoms. Examination of arthritic joints from
Externí odkaz:
https://doaj.org/article/8702464cfd724ac38870566e3107c99b
Autor:
Melissa S. O’Brien, Jason J. McDougall
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Serine proteases are elevated in arthritic joints where they can cleave protease activated receptors (PARs) to modulate pain and inflammation. Activation of protease-activated receptor 4 (PAR4) has been implicated in inflammatory joint pain. Whether
Externí odkaz:
https://doaj.org/article/31c8e75915d04412adfc9af4b8caff32
Publikováno v:
Biomolecules, Vol 12, Iss 11, p 1571 (2022)
The voltage gated sodium channels (Nav) 1.7, 1.8, and 1.9 are primarily located on nociceptors where they are involved in signalling neuropathic pain. This study examined the effect of Nav1.7 blockade on joint pain using either the small molecule inh
Externí odkaz:
https://doaj.org/article/db913d02dadc491e9f0a048246c85806
Autor:
Charlie H. T. Kwok, Yuta Kohro, Michael Mousseau, Melissa S. O’Brien, John R. Matyas, Jason J. McDougall, Tuan Trang
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Increased afferent input resulting from painful injury augments the activity of central nociceptive circuits via both neuron-neuron and neuron-glia interactions. Microglia, resident immune cells of the central nervous system (CNS), play a crucial rol
Externí odkaz:
https://doaj.org/article/f6a3eca28d1349de9516c2efbdc47656
Autor:
Jason J. McDougall
Publikováno v:
Osteoarthritis and Cartilage Open, Vol 1, Iss 1, Pp 100005- (2019)
Summary: Objective: This commentary aims to summarise the importance of the joint nervous system in maintaining joint homeostasis and the role of nerves in contributing to degenerative diseases such as osteoarthritis (OA). Methods: Pertinent scientif
Externí odkaz:
https://doaj.org/article/1044e6de59bf4191a573eb7e6aca895a
Autor:
Jason J. McDougall, Meagan McKenna
Publikováno v:
Br J Pharmacol
A significant number of cannabinoids are known to have analgesic and anti‐inflammatory properties in various diseases. Due to their presynaptic/terminal location, cannabinoid receptors can inhibit synaptic transmission and have the potential to reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b571b8c462a583e1388ba2053417069
https://doi.org/10.1111/bph.15208
https://doi.org/10.1111/bph.15208