Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Jason Isaacson"'
Autor:
Wade S Blair, Chris Pickford, Stephen L Irving, David G Brown, Marie Anderson, Richard Bazin, Joan Cao, Giuseppe Ciaramella, Jason Isaacson, Lynn Jackson, Rachael Hunt, Anne Kjerrstrom, James A Nieman, Amy K Patick, Manos Perros, Andrew D Scott, Kevin Whitby, Hua Wu, Scott L Butler
Publikováno v:
PLoS Pathogens, Vol 6, Iss 12, p e1001220 (2010)
Despite a high current standard of care in antiretroviral therapy for HIV, multidrug-resistant strains continue to emerge, underscoring the need for additional novel mechanism inhibitors that will offer expanded therapeutic options in the clinic. We
Externí odkaz:
https://doaj.org/article/8648c9ca262f41ee91d7fa89fbbd3323
Autor:
Jason Isaacson
Publikováno v:
Cell and Gene Therapy Insights. :1045-1045
Autor:
Rohit Duggal, Jason Isaacson, Heyue Zhou, James T. Patterson, Yanwen Fu, Tong Zhu, Gunnar F. Kaufmann, Ghazi Atassi, Lisa Kerwin, Damien Bresson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:5490-5495
Bioconjugate formats provide alternative strategies for antigen targeting with bispecific antibodies. Here, PSMA-targeted Fab conjugates were generated using different bispecific formats. Interchain disulfide bridging of an αCD3 Fab enabled installa
Autor:
Joan Cao, Hua Wu, Paul Griffin, Qinghai Peng, R. Lynn Jackson, Scott L. Butler, Wade S. Blair, Edward J. Murray, Chris Pickford, Amy K. Patick, Juin Fok-Seang, Manos Perros, Jason Isaacson
Publikováno v:
Antimicrobial Agents and Chemotherapy. 53:5080-5087
A new small-molecule inhibitor class that targets virion maturation was identified from a human immunodeficiency virus type 1 (HIV-1) antiviral screen. PF-46396, a representative molecule, exhibits antiviral activity against HIV-1 laboratory strains
Autor:
Anne-Marie Malfait, Lynn Jackson, Micky D. Tortorella, Hua Wu, Wade S. Blair, Alex Chu, Amy K. Patick, Joanne P. Graham, Qinghai Peng, Scott L. Butler, Joan Cao, Judith Jimenez, Jason Isaacson
Publikováno v:
Antimicrobial Agents and Chemotherapy. 51:3554-3561
More than 10 6 compounds were evaluated in a human immunodeficiency virus type 1 (HIV-1) high-throughput antiviral screen, resulting in the identification of a novel HIV-1 inhibitor (UK-201844). UK-201844 exhibited antiviral activity against HIV-1 NL
Autor:
Catherine A. O’Brien, Mark J. Sinnamon, Eric S. Martin, Nicole E. Baryla, Ping Jiang, Kenneth E. Hung, Julie L.C. Kan, Scott L. Weinrich, Bradly G. Wouters, Oivin Guicherit, Valeria Fantin, David Shields, Peter Olson, Trevor D. McKee, Nathan V. Lee, James G. Christensen, Tao Xie, Paul A. Rejto, Jatin Roper, Jason Isaacson, Todd VanArsdale, Peter J. Belmont
Publikováno v:
Science signaling. 7(351)
Targeted blockade of aberrantly activated signaling pathways is an attractive therapeutic strategy for solid tumors, but drug resistance is common. KRAS is a frequently mutated gene in human cancer but remains a challenging clinical target. Inhibitor
Autor:
Qinghai Peng, Joan Cao, Xinqiang Li, Jason Isaacson, George F.Z. Kong, Amy K. Patick, Wade S. Blair
Publikováno v:
Antiviral Research. 65:107-116
Antiviral high throughput screens remain a viable option for identifying novel target inhibitors. However, few antiviral screens have been reduced to practice on an industrial scale. In this study, we describe an HIV-1 dual reporter assay that allows
Autor:
Jennifer Buenviaje, Paul Szymanski, Francois Lebel, John A. Barrett, Kristi Elliott, Jeffrey Rosenbloom, Richard Einstein, Jason Isaacson, Srinivas Rengarajan
Publikováno v:
Cancer Immunology Research. 3:B16-B16
Cell Linking Moieties (CLMs) are bi-specific antibody fragments that are capable of recognizing epitopes on tumor cells and specific effector cells via unique cell surface receptors. They are comprised of 2 scFv elements recognizing unique epitopes,
Autor:
Andrew D. Scott, Chris Pickford, Manos Perros, Stephen L. Irving, Anne Maria Kristina Kjerrstrom, James A. Nieman, Giuseppe Ciaramella, David G. Brown, Lynn Jackson, Kevin Whitby, Wade S. Blair, Marie Anderson, Jason Isaacson, Amy K. Patick, Hua Wu, Joan Cao, Scott L. Butler, Rachael Hunt, Richard Bazin
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 6, Iss 12, p e1001220 (2010)
PLoS Pathogens, Vol 6, Iss 12, p e1001220 (2010)
Despite a high current standard of care in antiretroviral therapy for HIV, multidrug-resistant strains continue to emerge, underscoring the need for additional novel mechanism inhibitors that will offer expanded therapeutic options in the clinic. We
Publikováno v:
Antimicrobial agents and chemotherapy. 49(9)
Antiviral screens have proved useful for the identification of novel human immunodeficiency virus type 1 (HIV-1) inhibitors. In this study, we describe an HIV-1 full replication (HIV-1 Rep) assay that incorporates all of the targets required for repl