Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Jason H. Chaplin"'
Autor:
Martine Keenan, Eileen Ryan, Scott Cornwall, Andrea Khong, Jason H. Chaplin, Wayne M. Best, Karen L. White, R.C. Andrew Thompson, Catherine J. Perez, Ivan Scandale, Susan A. Charman, Michael J. Abbott, Paul W. Alexander, Francis C. K. Chiu, David M. Shackleford, Michael Campbell, Maria Koltun, Eric Chatelain, Adriana Botero, Julia Morizzi, Thomas W. von Geldern
Publikováno v:
Journal of Medicinal Chemistry
Chagas disease, caused by the protozoan parasite Trypanosoma cruzi (T. cruzi), is an increasing threat to global health. Available medicines were introduced over 40 years ago, have undesirable side effects, and give equivocal results of cure in the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38832ff07aa1233c73b2095f1457b219
https://doi.org/10.1021/jm401610c
https://doi.org/10.1021/jm401610c
Autor:
Eric Chatelain, Tatiana Y. Hargrove, Martine Keenan, Michael R. Waterman, Paul W. Alexander, Galina I. Lepesheva, Susan A. Charman, Jason H. Chaplin, Catherine J. Perez, Zdzislaw Wawrzak
Publikováno v:
Journal of Biological Chemistry. 288:31602-31615
Chagas disease, caused by the eukaryotic (protozoan) parasite Trypanosoma cruzi, is an alarming emerging global health problem with no clinical drugs available to treat the chronic stage. Azole inhibitors of sterol 14α-demethylase (CYP51) were prove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a301ec53c5e5d30f9c2826f0541adfbf
https://doi.org/10.1074/jbc.m113.497990
https://doi.org/10.1074/jbc.m113.497990
Autor:
Martine Keenan, Eileen Ryan, Susan A. Charman, Jason H. Chaplin, Karen L. White, Eric Chatelain, Gong Chen, Jean-Robert Ioset, Zhisen Wang, Michael J. Abbott, Scott Cornwall, Wayne M. Best, Sarah Keatley, Paul W. Alexander, Thomas W. von Geldern, Hugo Diao, Catherine J. Perez, R.C. Andrew Thompson
Publikováno v:
Future Medicinal Chemistry. 5:1733-1752
Background: Inhibitors of Trypanosoma cruzi with novel mechanisms of action are urgently required to diversify the current clinical and preclinical pipelines. Increasing the number and diversity of hits available for assessment at the beginning of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9de70cd8bb075d45ff1f1bb4e212c14b
https://doi.org/10.4155/fmc.13.139
https://doi.org/10.4155/fmc.13.139
Autor:
David K. Chalmers, Jason H. Chaplin, Tina C. Lavranos, Bernard L. Flynn, Annabell F. Leske, Dharam Paul, Gurmit S. Gill, Damian Grobelny, Ernest Hamel, Edmund Kostewicz, Julia Morizzi, M. Katherine Jung, David M. Shackleford, Gabriel Kremmidiotis, Susan A. Charman
Publikováno v:
Journal of Medicinal Chemistry. 54:6014-6027
A structure-activity relationship (SAR) guided design of novel tubulin polymerization inhibitors has resulted in a series of benzo[b]furans with exceptional potency toward cancer cells and activated endothelial cells. The potency of early lead compou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e50248d4cd2d0cae01b413445e930e2a
https://doi.org/10.1021/jm200454y
https://doi.org/10.1021/jm200454y
Autor:
Martine, Keenan, Jason H, Chaplin
Publikováno v:
Progress in medicinal chemistry. 54
Recent clinical trials investigating treatment of chronic indeterminate Chagas disease with two re-purposed azole anti-fungal drugs, posaconazole and ravuconazole, revealed their inferiority to the current standard-of-care benznidazole and highlighte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e433e60f3394d9bb951a1327b1034d2c
https://pubmed.ncbi.nlm.nih.gov/25727705
https://pubmed.ncbi.nlm.nih.gov/25727705
Autor:
Martine Keenan, Jason H. Chaplin
Recent clinical trials investigating treatment of chronic indeterminate Chagas disease with two re-purposed azole anti-fungal drugs, posaconazole and ravuconazole, revealed their inferiority to the current standard-of-care benznidazole and highlighte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba96f5803f332a87f24111e1e5922e88
https://doi.org/10.1016/bs.pmch.2014.12.001
https://doi.org/10.1016/bs.pmch.2014.12.001
Autor:
Bernard L. Flynn, Gurmit S. Gill, Damian W. Grobelny, Jason H. Chaplin, Dharam Paul, Annabell F. Leske, Tina C. Lavranos, David K. Chalmers, Susan A. Charman, Edmund Kostewicz, David M. Shackleford, Julia Morizzi, Ernest Hamel, M. Katherine Jung, Gabriel Kremmidiotis
Publikováno v:
Journal of Medicinal Chemistry; Sep2011, Vol. 54 Issue 17, p6014-6027, 14p