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Peptide Inhibitors of a-Amylase Based on Tendamistat: Development of Analogues with ϖ-Amino Acids Linking Critical Binding Segments

Autor: Stephen E. Schullery, Shakila Tobwala, Deborah L. Heyl, Rebecca W. Himm, A. Dammika Nandanie, Jeffrey Asbill, Jonathan K. Nzoma, Leo Solomon Lucas, Jennifer Kappler, Cara Jarosz, Hanna Palamma, Jason Groom, Elizabeth J. Blaney

Publikováno v: Protein & Peptide Letters. 12:275-280

Peptide analogues of Tendamistat which include the most essential residues linked by novel w-amino acids (X,Y,Z: H2N-(CH2)n-CO2H, where n=2-10) were designed, synthesized (Ac-Tyr15-X-Trp18-Arg19-Tyr20-Y-Thr55-Z-Asp58- Gly59-Tyr60-Ile61-Gly62-NH2), an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::08a81bf5befeb2ea364f17627420dd14
https://doi.org/10.2174/0929866053587110

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Peptide inhibitors of alpha-amylase based on tendamistat: development of analogues with omega-amino acids linking critical binding segments

Autor: Deborah L, Heyl, Shakila, Tobwala, Leo Solomon, Lucas, A Dammika, Nandanie, Rebecca W, Himm, Himm Jennifer, Kappler, Elizabeth J, Blaney, Jason, Groom, Jeffrey, Asbill, Jonathan K, Nzoma, Cara, Jarosz, Hanna, Palamma, Stephen E, Schullery

Publikováno v: Protein and peptide letters. 12(3)

Peptide analogues of Tendamistat which include the most essential residues linked by novel omega-amino acids (X,Y,Z: H2N-(CH2)n-CO(2)H, where n=2-10) were designed, synthesized (Ac-Tyr(15)-X-Trp(18)-Arg(19)-Tyr(20)-Y-Thr(55)-Z-Asp(58)-Gly(59)-Tyr(60)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::874268faf58f76d7853809db01acef58
https://pubmed.ncbi.nlm.nih.gov/15777278

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Peptide Inhibitors of α-Amylase Based on Tendamistat: Synthesis and Kinetic Studies

Autor: Deborah L. Heyl, Jeffrey Asbill, Leo Solomon Lucas, Mary Gillispie, Jennifer Kappler, Rebecca W. Himm, Jason Groom, Janice Lima, Jon Nzoma

Publikováno v: Peptides: The Wave of the Future ISBN: 9789401039055

Tendamistat is a tight-binding pseudo-irreversible inhibitor of mammalian α-amylases with a KI value of 9 • 10–12 M [1,2]. The crystal structure of the α-amylase-Tenda-mistat complex has been elucidated by X-ray techniques and nuclear magnetic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::13b5cb1fc4415421dc14c7b34a1c64c7
https://doi.org/10.1007/978-94-010-0464-0_252

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