Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Jason G. Wood"'
A somatic piRNA pathway in the Drosophila fat body ensures metabolic homeostasis and normal lifespan
Autor:
Brian C. Jones, Jason G. Wood, Chengyi Chang, Austin D. Tam, Michael J. Franklin, Emily R. Siegel, Stephen L. Helfand
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
The Piwi-interacting RNA (piRNA) pathway is known to suppress transposable elements in gonadal tissues. Here the authors provide evidence for a functional piRNA pathway in the somatic cells of theDrosophilafat body with roles in metabolism, immunolog
Externí odkaz:
https://doaj.org/article/375810040fa843ed8187901066d6abbf
Autor:
Jason G. Wood, Stephen L. Helfand
Publikováno v:
Frontiers in Genetics, Vol 4 (2013)
Epigenetic regulatory mechanisms are increasingly appreciated as central to a diverse array of biological processes, including aging. An association between heterochromatic silencing and longevity has long been recognized in yeast, and in more recent
Externí odkaz:
https://doaj.org/article/62a1fb69928e41519beb392108d4e6ac
Autor:
Jackson R. Taylor, Jason G. Wood, Evan Mizerak, Samuel Hinthorn, Julianna Liu, Matthew Finn, Sarah Gordon, Louis Zingas, Chengyi Chang, Mark A. Klein, John M. Denu, Vera Gorbunova, Andrei Seluanov, Jef D. Boeke, John M. Sedivy, Stephen L. Helfand
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Significance Sirt6 is well known for its role in regulating the aging process, particularly for its ability to extend lifespan in mice when overexpressed. However, the underlying molecular mechanisms responsible for lifespan regulation by Sirt6 are n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b51dda80bd2b29eaaec28d0497d21c6
https://doi.org/10.1073/pnas.2111176119
https://doi.org/10.1073/pnas.2111176119
A somatic piRNA pathway in the Drosophila fat body ensures metabolic homeostasis and normal lifespan
Autor:
Stephen L. Helfand, Chengyi Chang, Brian C. Jones, Jason G. Wood, Michael J. Franklin, Emily R. Siegel, Austin D. Tam
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
Nature Communications
Nature Communications
In gonadal tissues, the Piwi-interacting (piRNA) pathway preserves genomic integrity by employing 23–29 nucleotide (nt) small RNAs complexed with argonaute proteins to suppress parasitic mobile sequences of DNA called transposable elements (TEs). A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bfb402d30ee1be1ad2f890754049af7
https://doaj.org/article/375810040fa843ed8187901066d6abbf
https://doaj.org/article/375810040fa843ed8187901066d6abbf
Autor:
Matthew Finn, Sarah H. Gordon, Stephen L. Helfand, Jason G. Wood, Evan Mizerak, Julianna Liu, Jackson Taylor, Corinne Hutfilz
Publikováno v:
Innovation in Aging
Sirt6 is a multifunctional enzyme that regulates numerous cellular processes connected to longevity. Overexpressing Sirt6 extends lifespan in mice, but the underlying cellular mechanisms are unclear. Here, we used the powerful genetic tools and short
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55d1d4fee50033d50dfd9c75657e4693
https://doi.org/10.1093/geroni/igaa057.2617
https://doi.org/10.1093/geroni/igaa057.2617
Sirtuins are an evolutionarily conserved family of NAD+-dependent deacylases that control metabolism, stress response, genomic stability, and longevity. In mammals, three of these sirtuins (Sirt3, 4, and 5) are located in the mitochondrial, while the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bbd05a2ceef6ec82847345f417b23ae
https://europepmc.org/articles/PMC6229463/
https://europepmc.org/articles/PMC6229463/
Autor:
Claire Goodman, S Iliffe, Kate Walters, Drennan, Kalpa Kharicha, Benjamin Gardner, Jason G. Wood, Jill Manthorpe
Publikováno v:
Europe PubMed Central
Little is known about how to improve outcomes in mild frailty. We synthesised findings from three systematic reviews and qualitative work with 102 diverse participants (older people, caregivers, multi-disciplinary professionals) using a co-design pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d279cc0cb2acc3314b69c2239bcc57e1
https://europepmc.org/articles/PMC6183490/
https://europepmc.org/articles/PMC6183490/
Autor:
Stephen L. Helfand, Steven W. Criscione, Jill A. Kreiling, Marco De Cecco, John M. Sedivy, Brian C. Jones, Nicola Neretti, Jason G. Wood
Publikováno v:
Human Retrotransposons in Health and Disease ISBN: 9783319483436
Retrotransposable elements (RTEs) are abundant in the genomes of most species and continue to evolve and adapt to the defense mechanisms of their host cells. RTEs have contributed to the evolution of their hosts by creating germline genomic diversity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::942352e84d255b34214ccbf0807fd7b0
https://doi.org/10.1007/978-3-319-48344-3_13
https://doi.org/10.1007/978-3-319-48344-3_13
Publikováno v:
Innovation in Aging. 2:90-91
Sirtuins (SIRT1-7 in mammals) are a family of NAD+ dependent deacylases which regulate multiple cellular pathways involved in the aging process. SIRT6, in particular, has emerged as a key regulator of longevity, with roles in DNA repair, metabolism,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1365062e44e08270f383bf3beb3460ba
https://doi.org/10.1093/geroni/igy023.344
https://doi.org/10.1093/geroni/igy023.344
Autor:
Stephen L. Helfand, Nicola Neretti, Nan Jiang, Ethan Tobias, Jason G. Wood, Guyu Du, Rachel Whitaker
Publikováno v:
Aging (Albany NY)
Scopus-Elsevier
Scopus-Elsevier
During aging, changes in chromatin state that alter gene transcription have been postulated to result in expression of genes that are normally silenced, leading to deleterious age-related effects on cellular physiology. Despite the prevalence of this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dea6ab1cf6249256f045560e25b3442
https://doi.org/10.18632/aging.100614
https://doi.org/10.18632/aging.100614