Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Jason G. Pattis"'
Autor:
Subodh Kumar Samrat, Jimin Xu, Xuping Xie, Eleonora Gianti, Haiying Chen, Jing Zou, Jason G. Pattis, Khaled Elokely, Hyun Lee, Zhong Li, Michael L. Klein, Pei-Yong Shi, Jia Zhou, Hongmin Li
Publikováno v:
Antiviral Research. 205:105381
SARS-CoV-2 has raised the alarm to search for effective therapy for this virus. To date several vaccines have been approved but few available drugs reported recently still need approval from FDA. Remdesivir was approved for emergency use only. In thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e4840327d0c8de8a5d2a3e0878c9916
https://doi.org/10.1016/j.antiviral.2022.105381
https://doi.org/10.1016/j.antiviral.2022.105381
Autor:
Akram Hazeen, Jolanta Krucinska, Victoria L. Robinson, Heidi Erlandsen, Searle S. Duay, Eric R. May, Dennis L. Wright, Michael N. Lombardo, Jason G. Pattis
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Many years ago, the natural secondary metabolite SF2312, produced by the actinomycete Micromonospora, was reported to display broad spectrum antibacterial properties against both Gram-positive and Gram-negative bacteria. Recent studies have revealed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07b74224c343a8cedb977da9f0e54b98
https://pubmed.ncbi.nlm.nih.gov/31745118
https://pubmed.ncbi.nlm.nih.gov/31745118
Autor:
Eric R. May, Jason G. Pattis
Publikováno v:
Biophysical Journal. 110:1246-1254
Lassa virus protects its viral genome through the formation of a ribonucleoprotein complex in which the nucleoprotein (NP) encapsidates the single-stranded RNA genome. Crystal structures provide evidence that a conformational change must occur to all
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9696008d48835c7eba336df4952f5b9
https://doi.org/10.1016/j.bpj.2016.02.008
https://doi.org/10.1016/j.bpj.2016.02.008
Autor:
Eric R. May, Jason G. Pattis
Publikováno v:
Structure
Lassa virus contains a nucleoprotein (NP) that encapsulates the viral genomic RNA forming the ribonucleoprotein (RNP). The NP forms trimers that do not bind RNA, but a structure of only the NP N-terminal domain was co-crystallized with RNA bound. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04c0b4bb1bfc01a54915c04155b4275c
https://doi.org/10.1016/j.str.2020.03.002
https://doi.org/10.1016/j.str.2020.03.002
Publikováno v:
The journal of physical chemistry. B. 123(4)
The enzyme phosphodiesterase 6 (PDE6) is a critical component of the visual signaling pathway and functions to convert cGMP to GMP. The ability of PDE6 to affect cellular cGMP levels leads to deactivation of cGMP-gated ion channels in both rod and co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee6e3e5adfcd440bdd4a3d94ce9533c7
https://pubmed.ncbi.nlm.nih.gov/30616346
https://pubmed.ncbi.nlm.nih.gov/30616346
Publikováno v:
Journal of biological physics. 44(2)
Flock House virus (FHV) is a well-characterized model system to study infection mechanisms in non-enveloped viruses. A key stage of the infection cycle is the disruption of the endosomal membrane by a component of the FHV capsid, the membrane active
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b814f279e300368858d7ffd6c580648f
https://pubmed.ncbi.nlm.nih.gov/29644513
https://pubmed.ncbi.nlm.nih.gov/29644513
Autor:
Jason G. Pattis, Eric R. May
Publikováno v:
Biophysical Journal. 108(2)
Lassa virus is an enveloped virus, with a bisegmented ambisense single-stranded RNA genome, encoding only four gene products. The most abundant protein is the nucleoprotein (NP) which encapsidates the viral genomic RNA. Multiple structures of the NP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b41435dd046e45c619e4c7c690589ca
Publikováno v:
Biophysical Journal. 112:191a
Lassa is a dangerous Arenavirus, which is enveloped and has a single-stranded (ss)RNA genome. The nucleoprotein (NP) is the most abundant protein in the virion and functions to encapsidate the viral genome to form a ribonucleoprotein complex (RNP). S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::320d2e5b0abf44af8662e333c73165d4
https://doi.org/10.1016/j.bpj.2016.11.1061
https://doi.org/10.1016/j.bpj.2016.11.1061