Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Jason G. Chen"'
Autor:
Wenxue Wu, Gonzalo Hernandez, Weifeng Hu, Renmao Liu, Xiaogen Yang, Mark S. Bednarz, Jie Yan, Haiming Zhang, Lawrence F. Courtney, Yuelie Lu, Jason G. Chen
Publikováno v:
Tetrahedron. 69:4041-4046
A practical and scalable synthesis of in vivo sphingosine-1-phosphate lyase inhibitor LX2931 (1) is described. The synthetic route features an improved Buchi cyclocondensation of 2-ethoxyacrylonitrile (3) with either 1-amino-1-deoxy-d-fructose acetat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed02592a918bb4652d893c11092a71f5
https://doi.org/10.1016/j.tet.2013.03.071
https://doi.org/10.1016/j.tet.2013.03.071
Publikováno v:
Organic Letters. 6:3233-3235
[reaction: see text] A novel crystallization-induced chiral inversion of (S)-2-bromo-3-phenylpropanoic acid to its (R)-enantiomer with excellent enantiomeric excess (96-99%) is achieved. Optically pure (S)-2-acetylthio-3-phenylpropanoic acid can be p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fd0b9cf3aa33679a5a3ff87b253f53a
https://doi.org/10.1021/ol0489806
https://doi.org/10.1021/ol0489806
Publikováno v:
Tetrahedron Letters. 43:7585-7587
A method of synthesizing optically pure (S)-2-acetylthio-3-benzenepropanoic acid has been developed and good to excellent enantiomeric excess achieved via enzymatic resolution.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cdccc03dc78a8227f71efe3a43cfb2cb
https://doi.org/10.1016/s0040-4039(02)01820-8
https://doi.org/10.1016/s0040-4039(02)01820-8
Autor:
Ioannis N. Houpis, Changkang Huang, Jason G. Chen, Martine Canters, Ulrike Nettekoven, Renmao Liu
Publikováno v:
ChemInform. 40
The carboxylate anion has been used as a directing group to effect selective ortho-substituted derivatives 3 (>99:1 selectivity 50−80% yield). The solvent, base, and equivalents of base are the determining factors for the success of this reaction.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae8a21c30bc7976ffc37deecb445cbe7
https://doi.org/10.1002/chin.200917098
https://doi.org/10.1002/chin.200917098
Autor:
Renmao Liu, Jason G. Chen, Martine Canters, Ulrike Nettekoven, Changkang Huang, Ioannis N. Houpis
Publikováno v:
Organic letters. 10(24)
The carboxylate anion has been used as a directing group to effect selective ortho-substituted derivatives 3 (>99:1 selectivity 50−80% yield). The solvent, base, and equivalents of base are the determining factors for the success of this reaction.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4eacb1ed4f7c02af9dd1c81b49a20ab
https://pubmed.ncbi.nlm.nih.gov/19053734
https://pubmed.ncbi.nlm.nih.gov/19053734