Enhanced insulin sensitivity in skeletal muscle and liver by physiological overexpression of SIRT6

Autor: Jason G. Anderson, Giorgio Ramadori, Rafael M. Ioris, Mirco Galiè, Eric D. Berglund, Katie C. Coate, Teppei Fujikawa, Stefania Pucciarelli, Benedetta Moreschini, Augusto Amici, Cristina Andreani, Roberto Coppari

Publikováno v: Molecular Metabolism, Vol 4, Iss 11, Pp 846-856 (2015)

Objective: Available treatment for obesity and type 2 diabetes mellitus (T2DM) is suboptimal. Thus, identifying novel molecular target(s) exerting protective effects against these metabolic imbalances is of enormous medical significance. Sirt6 loss-

Externí odkaz: https://doaj.org/article/342ca602a10d4d6e8cd7632471dd0105

Reviewers

Autor: Jason G. Anderson, Christopher Bednarek, Jesse Samuel Bernstein, Gregory Burkard, Sean P. Butler, Anthony A. Cuneo, Aleeza Furman, Swaroop Gonchikar, Michael J. Jaffe, Nicholas R. Jasper, Paul R. Overdorf, Simon J. Shapiro, Tory B. Speert, Brady M. Wahlberg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aaf02fb33528b6d25210445f3496f2bb
https://doi.org/10.1016/b978-0-323-40153-1.08001-x

Lumbar Zygapophysial Joint Nerve (Medial Branch) Injection—Oblique Approach

Autor: Jason G. Anderson, Leland Berkwits, Michael B. Furman, Luis D. Baez-Cabrera

The fluoroscopically guided lumbar medial branch block will be described using the oblique view as the trajectory view, and needle placement is confirmed in the anteroposterior view. The oblique approach is the most convenient and the least technical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3ca3c2d294597f40c5df265ecd6d5ab4
https://doi.org/10.1016/b978-0-323-40153-1.00028-7

SIRT6 suppresses cancer stem-like capacity in tumors with PI3K activation independently of its deacetylase activity

Autor: Mirco Galiè, Rafael M. Ioris, Raul Mostoslavsky, Georgia Konstantinidou, Jason G. Anderson, Algera Goga, Denis Martinvalet, Carlos Sebastian, Giorgio Ramadori, Roberto Coppari, Pierre Baldi, Anne Charollais, Ebru Aras, Xavier Cyril Brenachot, Nicholas Ceglia

Publikováno v: Cell reports
Ioris, Rafael M.; Galié, Mirco; Ramadori, Giorgio; Anderson, Jason G.; Charollais, Anne; Konstantinidou, Georgia; Brenachot, Xavier; Aras, Ebru; Goga, Algera; Ceglia, Nicholas; Sebastián, Carlos; Martinvalet, Denis; Mostoslavsky, Raul; Baldi, Pierre; Coppari, Roberto (2017). SIRT6 Suppresses Cancer Stem-like Capacity in Tumors with PI3K Activation Independently of Its Deacetylase Activity. Cell reports, 18(8), pp. 1858-1868. Cell Press 10.1016/j.celrep.2017.01.065
Cell Reports, Vol 18, Iss 8, Pp 1858-1868 (2017)
Cell Reports
Cell Reports, Vol. 18, No 8 (2017) pp. 1858-1868

Summary Cancer stem cells (CSCs) have high tumorigenic capacity. Here, we show that stem-like traits of specific human cancer cells are reduced by overexpression of the histone deacetylase sirtuin 6 (SIRT6). SIRT6-sensitive cancer cells bear mutation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bd61614ec7a196eb3a961c5c6c3d319
http://hdl.handle.net/11562/958614

SIRT1 Deacetylase in POMC Neurons Is Required for Homeostatic Defenses against Diet-Induced Obesity

Autor: Mario Perello, Teppei Fujikawa, Giorgio Ramadori, Jason G. Anderson, Claudia R. Vianna, Raul Mostoslavsky, Ronald C. Stuart, Donald A. Morgan, Roberto Coppari, Kamal Rahmouni, Eduardo A. Nillni, Makoto Fukuda

Publikováno v: Cell Metabolism. 12(1):78-87

Summary Feeding on high-calorie (HC) diets induces serious metabolic imbalances, including obesity. Understanding the mechanisms against excessive body weight gain is critical for developing effective antiobesity strategies. Here we show that lack of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d886e798bea5d3e4ea36246ea5e24e4b