Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Jason G Smith"'
Publikováno v:
PLoS Pathogens, Vol 20, Iss 6, p e1012317 (2024)
Mammalian α-defensins are a family of abundant effector peptides of the mucosal innate immune system. Although primarily considered to be antimicrobial, α-defensins can increase rather than block infection by certain prominent bacterial and viral p
Externí odkaz:
https://doaj.org/article/e3e8dcbe444b49d1976e4cd42e22efe1
Publikováno v:
BMJ Open, Vol 14, Iss 2 (2024)
Introduction Pharmacists provide a spectrum of services and comprehensive medication management for patients with substance use disorders (SUDs) with many providing timely and increased access to care for patients. Prior studies have evaluated other
Externí odkaz:
https://doaj.org/article/7a6fd30411184ee38db381e12be92d6f
Autor:
Barbara G Bokhour, Gemmae M Fix, Aishwarya Khanna, Ekaterina Anderson, Rendelle E Bolton, Marva Foster, Jason G Smith, Varsha G Vimalananda
Publikováno v:
BMJ Open, Vol 12, Iss 12 (2022)
Introduction Patient-centred care and care coordination are each key priority areas for delivering high quality healthcare. However, the intersection between these two concepts is poorly characterised. We theorise that greater advancements in healthc
Externí odkaz:
https://doaj.org/article/ed9ba6aace8d4de4816cb67c4ff804df
Autor:
Karina Diaz, Ciara T Hu, Youngmee Sul, Beth A Bromme, Nicolle D Myers, Ksenia V Skorohodova, Anshu P Gounder, Jason G Smith
Publikováno v:
PLoS Pathogens, Vol 16, Iss 11, p e1009018 (2020)
Enteric alpha-defensins are potent effectors of innate immunity that are abundantly expressed in the small intestine. Certain enteric bacteria and viruses are resistant to defensins and even appropriate them to enhance infection despite neutralizatio
Externí odkaz:
https://doaj.org/article/34c75e27d60c4474ac4664893017405b
Autor:
Sarah S Wilson, Beth A Bromme, Mayumi K Holly, Mayim E Wiens, Anshu P Gounder, Youngmee Sul, Jason G Smith
Publikováno v:
PLoS Pathogens, Vol 13, Iss 6, p e1006446 (2017)
The small intestinal epithelium produces numerous antimicrobial peptides and proteins, including abundant enteric α-defensins. Although they most commonly function as potent antivirals in cell culture, enteric α-defensins have also been shown to en
Externí odkaz:
https://doaj.org/article/fd2216afedea466ca68a6bbfd4d8888b
Autor:
Anshu P Gounder, Nicolle D Myers, Piper M Treuting, Beth A Bromme, Sarah S Wilson, Mayim E Wiens, Wuyuan Lu, André J Ouellette, Katherine R Spindler, William C Parks, Jason G Smith
Publikováno v:
PLoS Pathogens, Vol 12, Iss 3, p e1005474 (2016)
α-defensins are abundant antimicrobial peptides with broad, potent antibacterial, antifungal, and antiviral activities in vitro. Although their contribution to host defense against bacteria in vivo has been demonstrated, comparable studies of their
Externí odkaz:
https://doaj.org/article/c0ee2ab0ebf04fb3b159d213bd915432
Publikováno v:
PLoS Pathogens, Vol 10, Iss 9, p e1004360 (2014)
Human α-defensins are potent anti-microbial peptides with the ability to neutralize bacterial and viral targets. Single alanine mutagenesis has been used to identify determinants of anti-bacterial activity and binding to bacterial proteins such as a
Externí odkaz:
https://doaj.org/article/ad892edd516044cd9b0a3422a861febb
Publikováno v:
PLoS Pathogens, Vol 10, Iss 7, p e1004186 (2014)
Externí odkaz:
https://doaj.org/article/12bf69cb0fe348f88aa4fd14c882633a
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e61571 (2013)
Human α-defensins are proteins of the innate immune system that suppress viral and bacterial infections by multiple mechanisms including membrane disruption. For viruses that lack envelopes, such as human adenovirus (HAdV), other, less well defined,
Externí odkaz:
https://doaj.org/article/b3161e911ecc4397aa513568d4d8ba4e
Autor:
Jason G Smith, Mariena Silvestry, Steffen Lindert, Wuyuan Lu, Glen R Nemerow, Phoebe L Stewart
Publikováno v:
PLoS Pathogens, Vol 6, Iss 6, p e1000959 (2010)
Defensins are effectors of the innate immune response with potent antibacterial activity. Their role in antiviral immunity, particularly for non-enveloped viruses, is poorly understood. We recently found that human alpha-defensins inhibit human adeno
Externí odkaz:
https://doaj.org/article/f8303a732833465089b6356b5079e7a6