Zobrazeno 1 - 10
of 112
pro vyhledávání: '"Jason Ernst"'
Autor:
Artur Jaroszewicz, Jason Ernst
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-31 (2023)
Abstract Various computational approaches have been developed to annotate epigenomes on a per-position basis by modeling combinatorial and spatial patterns within epigenomic data. However, such annotations are less suitable for gene-based analyses. W
Externí odkaz:
https://doaj.org/article/4e43563159b244bea8d48984b2129be0
Autor:
Ha Vu, Jason Ernst
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-13 (2023)
Abstract A large-scale application of the “stacked modeling” approach for chromatin state discovery previously provides a single “universal” chromatin state annotation of the human genome based jointly on data from many cell and tissue types.
Externí odkaz:
https://doaj.org/article/9b2e0e9a406741c9beaea31c6c520e51
Publikováno v:
IEEE Access, Vol 11, Pp 50805-50822 (2023)
One of the essential processes in Mobile Ad hoc Networks (MANETs) is blind flooding to discover routes between source and destination mobile nodes. As the density of nodes in the network increases, the number of broadcast packets increases exponentia
Externí odkaz:
https://doaj.org/article/a128ca90366d42fca0ae6d1a6523f391
Autor:
Adriana Arneson, Amin Haghani, Michael J. Thompson, Matteo Pellegrini, Soo Bin Kwon, Ha Vu, Emily Maciejewski, Mingjia Yao, Caesar Z. Li, Ake T. Lu, Marco Morselli, Liudmilla Rubbi, Bret Barnes, Kasper D. Hansen, Wanding Zhou, Charles E. Breeze, Jason Ernst, Steve Horvath
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Methods to probe DNA methylation in the majority of non-human mammals are lacking. Here the authors developed a Mammalian Methylation Array that includes 36k well-conserved CpGs in mammals which will facilitate cross-species comparisons. They annotat
Externí odkaz:
https://doaj.org/article/8a6ba8ee9691468fa2b7b8d99e1a4571
Autor:
Ha Vu, Jason Ernst
Publikováno v:
Genome Biology, Vol 23, Iss 1, Pp 1-37 (2022)
Abstract Background Genome-wide maps of chromatin marks such as histone modifications and open chromatin sites provide valuable information for annotating the non-coding genome, including identifying regulatory elements. Computational approaches such
Externí odkaz:
https://doaj.org/article/79e57b111ee84b619f69cb6d4e57c23a
Autor:
Soo Bin Kwon, Jason Ernst
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
Kwon and Ernst applied the comparative genomics method, ConsHMM, to the multi-strain alignments of different coronaviruses in order to annotate every base of the SARS-CoV-2 genome with conservation states. The conservation states reflect sequence ali
Externí odkaz:
https://doaj.org/article/93d5a587959f4192b539707ede788392
Autor:
Soo Bin Kwon, Jason Ernst
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Understanding conserved functional genomic properties between human and mouse provides important context for mouse model studies. Here, the authors present a genome-wide conservation score integrating epigenomic, transcription factor binding, and tra
Externí odkaz:
https://doaj.org/article/0932a4110b8849139c03740e978a6ce1
Autor:
Olivera Grujic, Tanya N. Phung, Soo Bin Kwon, Adriana Arneson, Yuju Lee, Kirk E. Lohmueller, Jason Ernst
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Genome-wide maps of evolutionary constraint and large-scale compendia of epigenomic and transcription factor data provide complementary information for genome annotation. Here, the authors develop the Constrained Non-Exonic Predictor (CNEP) that enab
Externí odkaz:
https://doaj.org/article/627265ce26714edfacd642533c677bf1
Autor:
Arash Pezhouman, Ngoc B. Nguyen, Alexander J. Sercel, Thang L. Nguyen, Ali Daraei, Shan Sabri, Douglas J. Chapski, Melton Zheng, Alexander N. Patananan, Jason Ernst, Kathrin Plath, Thomas M. Vondriska, Michael A. Teitell, Reza Ardehali
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Background: Human embryonic stem cell-derived cardiomyocytes (hESC-CMs) can be used as a source for cell delivery to remuscularize the heart after myocardial infarction. Despite their therapeutic potential, the emergence of ventricular arrhythmias ha
Externí odkaz:
https://doaj.org/article/b15067c9d27942a09f1c72c4d61693ac
Autor:
Gabriel B. Ferguson, Ben Van Handel, Maxwell Bay, Petko Fiziev, Tonis Org, Siyoung Lee, Ruzanna Shkhyan, Nicholas W. Banks, Mila Scheinberg, Ling Wu, Biagio Saitta, Joseph Elphingstone, A. Noelle Larson, Scott M. Riester, April D. Pyle, Nicholas M. Bernthal, Hanna KA Mikkola, Jason Ernst, Andre J. van Wijnen, Michael Bonaguidi, Denis Evseenko
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Human development provides a roadmap for advancing pluripotent stem cell-based regenerative therapies. Here the authors mapped human skeletogenesis using RNA sequencing on 5 cell types from a single foetal stage as well as chondrocytes at 4 stages in
Externí odkaz:
https://doaj.org/article/1d363aed9a4649c2a647c893fe451af6