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Advancing the application of organoids, tissue-on-a-chip, and other emerging in vitro models to support cell and gene therapy

Autor: Jason Ekert, Marie Davies, Pelin Candarlioglu

Publikováno v: Cell and Gene Therapy Insights. :75-85

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c62dc0c00f1962cf7a070d460015659d
https://doi.org/10.18609/cgti.2022.002

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Lung Tumor Microphysiological System with 3D Endothelium to Evaluate Modulators of T-Cell Infiltration

Autor: Katrina M. Wisdom, Johnny Suijker, Lenie van den Broek, BanuPriya Sridharan, Taraka Sai Pavan Grandhi, Aaron Cheng, Mahdi Lamb, Steven A. Titus, Andrew Gehman, Derek Poore, Niyant Shah, Shih-Hsun Cheng, Edward Kim, Sue Griffin, Jason Ekert

Lung cancer is a leading cause of death worldwide, with only a fraction of patients responding to immunotherapy. The correlation between increased T-cell infiltration and positive patient outcomes has motivated the search for therapeutics promoting T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8a5ad874b6f3d5ab84a948e72e36fb57
https://doi.org/10.1101/2022.08.03.502507

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Phenotypic Characterization of Liver Sinusoidal Endothelial Cells on the Human Liver-Chip for Potential in vitro Therapeutic Antibody Pharmacology Applications

Autor: Pelin L. Candarlioglu, Sushma Jadalannagari, Jake Chaff, James Velez, Sannidhi R Joshipura, Marianne Kanellias, Alexander P. Simpson, S. Jordan Kerns, Lorna Ewart, Manjunath Hegde, Jason Ekert

Liver plays a vital role in the human immune system, in the internalization and catabolic clearance of therapeutic antibodies and antibody-bound immune complexes via Fc-receptor (FcR) binding on the hepatic reticuloendothelial system cells. This Fc p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4d8befb581d9d4c79f28c4c07e7e2293
https://doi.org/10.1101/2022.03.04.482954

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Label-free multimodal multiphoton imaging of Liver-on-a-Chip models

Autor: Aneesh Alex, Terrence Roh, BanuPriya Sridharan, Jindou Shi, Prabuddha Mukherjee, Eric J. Chaney, James Tunstead, Jan Majer, Kajari Bera, Darold R. Spillman, Marina Marjanovic, Jason Ekert, Steve R. Hood, Stephen A. Boppart

Publikováno v: Label-free Biomedical Imaging and Sensing (LBIS) 2022.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a8688b6f58f5ff8ff9dc93552920e049
https://doi.org/10.1117/12.2608861

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