Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Jason E. Toombs"'
Autor:
Karoliina Stefanius, Kelly Servage, Marcela de Souza Santos, Hillery Fields Gray, Jason E Toombs, Suneeta Chimalapati, Min S Kim, Venkat S Malladi, Rolf Brekken, Kim Orth
Publikováno v:
eLife, Vol 8 (2019)
Cancer evolves through a multistep process that occurs by the temporal accumulation of genetic mutations. Tumor-derived exosomes are emerging contributors to tumorigenesis. To understand how exosomes might contribute to cell transformation, we utiliz
Externí odkaz:
https://doaj.org/article/d1922c4d232445f49f2061be196cfa8a
Autor:
Nick Loizos, Rolf A. Brekken, Colleen Burns, Timothy Bailey, Jennifer Malaby, Inga Duignan, Michael Peyton, Jason E. Toombs, Michael T. Dellinger, Puja Gupta, David E. Gerber
PDF file, 156K, Species and target specificity of IMC-3G3 and 1E10.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::433fb0e5b3f734405f2853cb0aa6d4da
https://doi.org/10.1158/1535-7163.22497432
https://doi.org/10.1158/1535-7163.22497432
Autor:
Rolf A. Brekken, Jason M. Foulks, Steven L. Warner, Huocong Huang, Jason E. Toombs, Ali Rizvi, Emily N. Arner, Yuqing Zhang
Supplementary figures show the efficacy of TP-0903 and its effects on tumor infiltrating immune cells and EMT markers expression.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b35f8e3f35bd872f4b714209c15c10b
https://doi.org/10.1158/1535-7163.22522456.v1
https://doi.org/10.1158/1535-7163.22522456.v1
Autor:
Rolf A. Brekken, James B. Lorens, Thomas M. Wilkie, Muhammad S. Beg, Yuqing Zhang, Jason E. Toombs, Jill Westcott, Zhaoning Wang, Huocong Huang, Natalie Z. Phinney, Wenting Du
Pancreatic ductal adenocarcinoma (PDA), a leading cause of cancer-related death in the United States, has a high metastatic rate, and is associated with persistent immune suppression. AXL, a member of the TAM (TYRO3, AXL, MERTK) receptor tyrosine kin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::216cadfd0bd0ac7653262927c32b5dd8
https://doi.org/10.1158/1541-7786.c.6545003.v1
https://doi.org/10.1158/1541-7786.c.6545003.v1
Autor:
Nick Loizos, Rolf A. Brekken, Colleen Burns, Timothy Bailey, Jennifer Malaby, Inga Duignan, Michael Peyton, Jason E. Toombs, Michael T. Dellinger, Puja Gupta, David E. Gerber
In lung cancer, platelet-derived growth factor receptor α (PDGFRα) is expressed frequently by tumor-associated stromal cells and by cancer cells in a subset of tumors. We sought to determine the effect of targeting stromal PDGFRα in preclinical lu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::874c4025e37e3874f2ebebd8c1b83be5
https://doi.org/10.1158/1535-7163.c.6535614.v1
https://doi.org/10.1158/1535-7163.c.6535614.v1
Autor:
Nick Loizos, Rolf A. Brekken, Colleen Burns, Timothy Bailey, Jennifer Malaby, Inga Duignan, Michael Peyton, Jason E. Toombs, Michael T. Dellinger, Puja Gupta, David E. Gerber
PDF file, 46K.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7225d085b5054d300fe6894dff981838
https://doi.org/10.1158/1535-7163.22497429
https://doi.org/10.1158/1535-7163.22497429
Autor:
Rolf A. Brekken, James B. Lorens, Thomas M. Wilkie, Muhammad S. Beg, Yuqing Zhang, Jason E. Toombs, Jill Westcott, Zhaoning Wang, Huocong Huang, Natalie Z. Phinney, Wenting Du
S1. Gene Ontology (GO) analysis of gene clusters from AXL-positive cancer cell populations based on scRNA-Seq data from Hosein et al (35). S2. Expression of Axl in tumors from WT and AXLLacZ/LacZ (AAKIC) KIC mice. S3. Tumor tissues from KIC and AxlLa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4577a74526a1ed25a8a638910a8dc765
https://doi.org/10.1158/1541-7786.22526093
https://doi.org/10.1158/1541-7786.22526093
Autor:
Rolf A. Brekken, Jason M. Foulks, Steven L. Warner, Huocong Huang, Jason E. Toombs, Ali Rizvi, Emily N. Arner, Yuqing Zhang
Pancreatic cancer is the third leading cause of cancer-related deaths in the United States with a 5-year survival less than 5%. Resistance to standard therapy and limited response to immune checkpoint blockade due to the immunosuppressive and stroma-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e0a0079a727f282df95fa2a1a26fba4
https://doi.org/10.1158/1535-7163.c.6543388
https://doi.org/10.1158/1535-7163.c.6543388
Autor:
Rolf A. Brekken, James B. Lorens, Anirban Maitra, N.V. Rajeshkumar, Shinichi Yabuuchi, Victoria H. Cruz, Jason E. Toombs, Mary Topalovski, Katarzyna Wnuk-Lipinska, Noah B. Sorrelle, Wenting Du, Kathleen F. Ludwig
Supplementary Figures 1-7 and Supplementary Table 1. Supplementary Figure 1 H&E stain and trichrome stain of representative 7-week-old KIC tumor tissue. Supplementary Figure 2 Axl gene expression in pancreatic cancer patient-derived xenografts. Suppl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::318dd776a2f705e23be8ac011adcc930
https://doi.org/10.1158/0008-5472.22417191
https://doi.org/10.1158/0008-5472.22417191
Autor:
Rolf A. Brekken, James B. Lorens, Anirban Maitra, N.V. Rajeshkumar, Shinichi Yabuuchi, Victoria H. Cruz, Jason E. Toombs, Mary Topalovski, Katarzyna Wnuk-Lipinska, Noah B. Sorrelle, Wenting Du, Kathleen F. Ludwig
Expanded Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35447ae3039f835ba31b710398913978
https://doi.org/10.1158/0008-5472.22417188.v1
https://doi.org/10.1158/0008-5472.22417188.v1