Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Jason E. Hudak"'
Autor:
Angelo Solania, Mason J. Appel, Peter V. Robinson, Brian Belardi, Carolyn R. Bertozzi, Jason E. Hudak
Publikováno v:
Bioorganic & Medicinal Chemistry. 24:4791-4800
The generation of homogeneously glycosylated proteins is essential for defining glycoform-specific activity and improving protein-based therapeutics. We present a novel glycodendron prosthetic which can be site-selectively appended to recombinant pro
Autor:
David Alvarez, Dennis L. Kasper, Ulrich H. von Andrian, Jason E. Hudak, Deniz Erturk-Hasdemir, Naama Geva-Zatorsky, Suryasarathi Dasgupta, Nicola C. Reading
Publikováno v:
Nature Medicine. 21:1091-1100
The intestine is densely populated by anaerobic commensal bacteria. These microorganisms shape immune system development, but understanding of host-commensal interactions is hampered by a lack of tools for studying the anaerobic intestinal environmen
Publikováno v:
Nature microbiology
The immunomodulatory surface molecules of commensal and pathogenic bacteria are critical to microorganisms' survival and the host's response1,2. Recent studies have highlighted the unique and important responses elicited by commensal-derived surface
Autor:
Jason E. Hudak, Carolyn R. Bertozzi
Publikováno v:
Chemistry & Biology. 21(1):16-37
The beginning of the 20(th) century marked the dawn of modern medicine with glycan-based therapies at the forefront. However, glycans quickly became overshadowed as DNA- and protein-focused treatments became readily accessible. The recent development
Publikováno v:
Nature chemical biology
The increase of cell surface sialic acid is a characteristic shared by many tumor types. A correlation between hypersialylation and immunoprotection has been observed, but few hypotheses have provided a mechanistic understanding of this immunosuppres
Publikováno v:
Journal of the American Chemical Society
Homogeneously glycosylated proteins are important targets for fundamental research and for biopharmaceutical development. The use of unnatural protein–glycan linkages bearing structural similarity to their native counterparts can accelerate the syn
Autor:
Anthony J. Berdis, Jennifer Fishovitz, Kristin S. Ko, Hilary Frase, Min Li, Sandra Craig, Carolyn K. Suzuki, Irene Lee, Jason E. Hudak
Publikováno v:
ACS Chemical Biology. 6:781-788
Lon and ClpXP are the only soluble ATP-dependent proteases within the mammalian mitochondria matrix, which function in protein quality control by selectively degrading misfolded, misassembled, or damaged proteins. Chemical tools to study these protea
Publikováno v:
Biochemistry. 45:8264-8274
Lon is a homo-oligomeric ATP-dependent serine protease which functions in the degradation of damaged and certain regulatory proteins. The importance of Lon activity in bacterial pathogenicity has led to its emergence as a target in the development of
Autor:
Jason E. Hudak, Dennis L. Kasper, Naama Geva-Zatorsky, Suryasarathi Dasgupta, Ulrich H. von Andrian, David Alvarez, Deniz Erturk-Hasdemir, Nicola C. Reading Mans
Publikováno v:
Cancer Immunology Research. 4:IA18-IA18
Adaptive co-evolution has formed a complex network of inextricable bonds between the resident microbes and the mammalian host. These symbiotic microbes are now believed to have critical impacts on human health. One of the most common gut symbionts, B
Publikováno v:
Cancer Immunology Research. 4:PR07-PR07
The biomass of the human microbiome is estimated to account for 1-3% of total host body weight. This bulk quantity includes an abundance of microbial metabolites and macromolecules that are sensed by and alter host physiology. In fact, recent studies