Zobrazeno 1 - 10
of 300
pro vyhledávání: '"Jason E. Gestwicki"'
Autor:
Cory M. Nadel, Saugat Pokhrel, Kristin Wucherer, Abby Oehler, Aye C. Thwin, Koli Basu, Matthew D. Callahan, Daniel R. Southworth, Daniel A. Mordes, Charles S. Craik, Jason E. Gestwicki
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Microtubule-associated protein tau (MAPT/tau) accumulates in a family of neurodegenerative diseases, including Alzheimer’s disease (AD). In disease, tau is aberrantly modified by post-translational modifications (PTMs), including hyper-pho
Externí odkaz:
https://doaj.org/article/65e099c2e88a4ef08f3a505a925ec40b
Autor:
Pengfei Xu, Joy C. Yang, Bo Chen, Shu Ning, Xiong Zhang, Leyi Wang, Christopher Nip, Yuqiu Shen, Oleta T. Johnson, Gabriela Grigorean, Brett Phinney, Liangren Liu, Qiang Wei, Eva Corey, Clifford G. Tepper, Hong-Wu Chen, Christopher P. Evans, Marc A. Dall’Era, Allen C. Gao, Jason E. Gestwicki, Chengfei Liu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract N-Myc is a key driver of neuroblastoma and neuroendocrine prostate cancer (NEPC). One potential way to circumvent the challenge of undruggable N-Myc is to target the protein homeostasis (proteostasis) system that maintains N-Myc levels. Here
Externí odkaz:
https://doaj.org/article/7245d627558b40309015d3fca64f4865
Autor:
Sook Wah Yee, Luis Ferrández-Peral, Pol Alentorn-Moron, Claudia Fontsere, Merve Ceylan, Megan L. Koleske, Niklas Handin, Virginia M. Artegoitia, Giovanni Lara, Huan-Chieh Chien, Xujia Zhou, Jacques Dainat, Arthur Zalevsky, Andrej Sali, Colin M. Brand, Finn D. Wolfreys, Jia Yang, Jason E. Gestwicki, John A. Capra, Per Artursson, John W. Newman, Tomàs Marquès-Bonet, Kathleen M. Giacomini
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract SLC22A10 is an orphan transporter with unknown substrates and function. The goal of this study is to elucidate its substrate specificity and functional characteristics. In contrast to orthologs from great apes, human SLC22A10, tagged with gr
Externí odkaz:
https://doaj.org/article/a48ee6cda4514840ac818713e505c1b2
Autor:
Miyuu Tanaka, Ryoko Fujikawa, Takahiro Sekiguchi, Jason Hernandez, Oleta T. Johnson, Daisuke Tanaka, Kenta Kumafuji, Tadao Serikawa, Hieu Hoang Trung, Kosuke Hattori, Tomoji Mashimo, Mitsuru Kuwamura, Jason E. Gestwicki, Takashi Kuramoto
Publikováno v:
Frontiers in Neuroscience, Vol 18 (2024)
Neuroaxonal dystrophy (NAD) is a neurodegenerative disease characterized by spheroid (swollen axon) formation in the nervous system. In the present study, we focused on a newly established autosomal recessive mutant strain of F344-kk/kk rats with hin
Externí odkaz:
https://doaj.org/article/b5bf84a562e746e195914f25780aba1c
Autor:
Daniel C. Carrettiero, Maria C. Almeida, Andrew P. Longhini, Jennifer N. Rauch, Dasol Han, Xuemei Zhang, Saeed Najafi, Jason E. Gestwicki, Kenneth S. Kosik
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
While cellular stress shuts down translation, how protein degradation occurs with stress is incompletely understood. The authors describe a stress-induced phase separated organelle that mediates ubiquitin-independent degradation in the proteasome.
Externí odkaz:
https://doaj.org/article/05017f2d937b43558ca0b32aba9c135f
Autor:
Pengfei Xu, Joy C. Yang, Shu Ning, Bo Chen, Christopher Nip, Qiang Wei, Liangren Liu, Oleta T. Johnson, Allen C. Gao, Jason E. Gestwicki, Christopher P. Evans, Chengfei Liu
Publikováno v:
Pharmacological Research, Vol 189, Iss , Pp 106692- (2023)
Ubiquitin proteasome activity is suppressed in enzalutamide resistant prostate cancer cells, and the heat shock protein 70/STIP1 homology and U-box-containing protein 1 (HSP70/STUB1) machinery are involved in androgen receptor (AR) and AR variant pro
Externí odkaz:
https://doaj.org/article/0aa5beefd47948149ef46484906a60a3
Autor:
Chao Wang, Li Fan, Rabia R. Khawaja, Bangyan Liu, Lihong Zhan, Lay Kodama, Marcus Chin, Yaqiao Li, David Le, Yungui Zhou, Carlo Condello, Lea T. Grinberg, William W. Seeley, Bruce L. Miller, Sue-Ann Mok, Jason E. Gestwicki, Ana Maria Cuervo, Wenjie Luo, Li Gan
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Wang et al show that microglial NF-κB activation is essential for tau spreading and tau-mediated spatial learning and memory deficits in tauopathy mice. Inactivation of NF-κB reversed tau associated microglial states and rescued autophagy deficits.
Externí odkaz:
https://doaj.org/article/1f855da0da7c4c2995106bb45af63b8f
Autor:
Kwadwo A. Opoku-Nsiah, Andres H. de la Pena, Sarah K. Williams, Nikita Chopra, Andrej Sali, Gabriel C. Lander, Jason E. Gestwicki
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
The proteasome complexes, composed of 20S core particles and one or two regulatory particles (proteasome activators), degrade most eukaryotic proteins. Here, the authors identify a sequence motif and resolve its interactions mediating the activation
Externí odkaz:
https://doaj.org/article/12967c8972e54d50b98fad4d225e07ce
Autor:
Benjamin Caballero, Mathieu Bourdenx, Enrique Luengo, Antonio Diaz, Peter Dongmin Sohn, Xu Chen, Chao Wang, Yves R. Juste, Susanne Wegmann, Bindi Patel, Zapporah T. Young, Szu Yu Kuo, Jose Antonio Rodriguez-Navarro, Hao Shao, Manuela G. Lopez, Celeste M. Karch, Alison M. Goate, Jason E. Gestwicki, Bradley T. Hyman, Li Gan, Ana Maria Cuervo
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
The tau protein has been implicated in neurodegenerative disorders and can propagate from cell to cell. Here, the authors show that tau acetylation reduces its degradation by chaperone-mediated autophagy, causing re-routing to other autophagic pathwa
Externí odkaz:
https://doaj.org/article/212054e33af24b80a55cb5e3dd710b36
Autor:
Xu Chen, Yaqiao Li, Chao Wang, Yinyan Tang, Sue-Ann Mok, Richard M. Tsai, Julio C. Rojas, Anna Karydas, Bruce L. Miller, Adam L. Boxer, Jason E. Gestwicki, Michelle Arkin, Ana Maria Cuervo, Li Gan
Publikováno v:
Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-19 (2020)
Abstract Background The trans-neuronal propagation of tau has been implicated in the progression of tau-mediated neurodegeneration. There is critical knowledge gap in understanding how tau is released and transmitted, and how that is dysregulated in
Externí odkaz:
https://doaj.org/article/8fad18ce72e441399290291663f48c2c