Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Jason E Toombs"'
Autor:
Karoliina Stefanius, Kelly Servage, Marcela de Souza Santos, Hillery Fields Gray, Jason E Toombs, Suneeta Chimalapati, Min S Kim, Venkat S Malladi, Rolf Brekken, Kim Orth
Publikováno v:
eLife, Vol 8 (2019)
Cancer evolves through a multistep process that occurs by the temporal accumulation of genetic mutations. Tumor-derived exosomes are emerging contributors to tumorigenesis. To understand how exosomes might contribute to cell transformation, we utiliz
Externí odkaz:
https://doaj.org/article/d1922c4d232445f49f2061be196cfa8a
Autor:
Shanna A Arnold, Lee B Rivera, Juliet G Carbon, Jason E Toombs, Chi-Lun Chang, Amy D Bradshaw, Rolf A Brekken
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e31384 (2012)
Pancreatic adenocarcinoma, a desmoplastic disease, is the fourth leading cause of cancer-related death in the Western world due, in large part, to locally invasive primary tumor growth and ensuing metastasis. SPARC is a matricellular protein that gov
Externí odkaz:
https://doaj.org/article/b0a53f3997654674a95e5e63977da4a0
Autor:
Laura A Sullivan, Juliet G Carbon, Christina L Roland, Jason E Toombs, Mari Nyquist-Andersen, Anita Kavlie, Kyle Schlunegger, James A Richardson, Rolf A Brekken
Publikováno v:
PLoS ONE, Vol 5, Iss 8, p e12031 (2010)
Vascular endothelial growth factor (VEGF) is critical for physiological and pathological angiogenesis. Within the tumor microenvironment, VEGF functions as an endothelial cell survival factor, permeability factor, mitogen, and chemotactic agent. The
Externí odkaz:
https://doaj.org/article/1183e444564844c3b2fa4ec922339798
Autor:
Christina L Roland, Kristi D Lynn, Jason E Toombs, Sean P Dineen, D Gomika Udugamasooriya, Rolf A Brekken
Publikováno v:
PLoS ONE, Vol 4, Iss 11, p e7669 (2009)
The effect of blocking VEGF activity in solid tumors extends beyond inhibition of angiogenesis. However, no studies have compared the effectiveness of mechanistically different anti-VEGF inhibitors with respect to changes in tumor growth and alterati
Externí odkaz:
https://doaj.org/article/1f8ba5d37820475c9124a92a94922d4e
Autor:
Nick Loizos, Rolf A. Brekken, Colleen Burns, Timothy Bailey, Jennifer Malaby, Inga Duignan, Michael Peyton, Jason E. Toombs, Michael T. Dellinger, Puja Gupta, David E. Gerber
PDF file, 156K, Species and target specificity of IMC-3G3 and 1E10.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::433fb0e5b3f734405f2853cb0aa6d4da
https://doi.org/10.1158/1535-7163.22497432
https://doi.org/10.1158/1535-7163.22497432
Autor:
Rolf A. Brekken, Jason M. Foulks, Steven L. Warner, Huocong Huang, Jason E. Toombs, Ali Rizvi, Emily N. Arner, Yuqing Zhang
Supplementary figures show the efficacy of TP-0903 and its effects on tumor infiltrating immune cells and EMT markers expression.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b35f8e3f35bd872f4b714209c15c10b
https://doi.org/10.1158/1535-7163.22522456.v1
https://doi.org/10.1158/1535-7163.22522456.v1
Autor:
Rolf A. Brekken, James B. Lorens, Thomas M. Wilkie, Muhammad S. Beg, Yuqing Zhang, Jason E. Toombs, Jill Westcott, Zhaoning Wang, Huocong Huang, Natalie Z. Phinney, Wenting Du
Pancreatic ductal adenocarcinoma (PDA), a leading cause of cancer-related death in the United States, has a high metastatic rate, and is associated with persistent immune suppression. AXL, a member of the TAM (TYRO3, AXL, MERTK) receptor tyrosine kin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::216cadfd0bd0ac7653262927c32b5dd8
https://doi.org/10.1158/1541-7786.c.6545003.v1
https://doi.org/10.1158/1541-7786.c.6545003.v1
Autor:
Nick Loizos, Rolf A. Brekken, Colleen Burns, Timothy Bailey, Jennifer Malaby, Inga Duignan, Michael Peyton, Jason E. Toombs, Michael T. Dellinger, Puja Gupta, David E. Gerber
In lung cancer, platelet-derived growth factor receptor α (PDGFRα) is expressed frequently by tumor-associated stromal cells and by cancer cells in a subset of tumors. We sought to determine the effect of targeting stromal PDGFRα in preclinical lu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::874c4025e37e3874f2ebebd8c1b83be5
https://doi.org/10.1158/1535-7163.c.6535614.v1
https://doi.org/10.1158/1535-7163.c.6535614.v1
Autor:
Nick Loizos, Rolf A. Brekken, Colleen Burns, Timothy Bailey, Jennifer Malaby, Inga Duignan, Michael Peyton, Jason E. Toombs, Michael T. Dellinger, Puja Gupta, David E. Gerber
PDF file, 46K.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7225d085b5054d300fe6894dff981838
https://doi.org/10.1158/1535-7163.22497429
https://doi.org/10.1158/1535-7163.22497429
Autor:
Rolf A. Brekken, James B. Lorens, Thomas M. Wilkie, Muhammad S. Beg, Yuqing Zhang, Jason E. Toombs, Jill Westcott, Zhaoning Wang, Huocong Huang, Natalie Z. Phinney, Wenting Du
S1. Gene Ontology (GO) analysis of gene clusters from AXL-positive cancer cell populations based on scRNA-Seq data from Hosein et al (35). S2. Expression of Axl in tumors from WT and AXLLacZ/LacZ (AAKIC) KIC mice. S3. Tumor tissues from KIC and AxlLa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4577a74526a1ed25a8a638910a8dc765
https://doi.org/10.1158/1541-7786.22526093
https://doi.org/10.1158/1541-7786.22526093