Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Jason D. Shepherd"'
Autor:
Alicia Ravens, Cornelia N. Stacher-Hörndli, Jared Emery, Susan Steinwand, Jason D. Shepherd, Christopher Gregg
Publikováno v:
iScience, Vol 26, Iss 5, Pp 106761- (2023)
Summary: Foraging in animals relies on innate decision-making heuristics that can result in suboptimal cognitive biases in some contexts. The mechanisms underlying these biases are not well understood, but likely involve strong genetic effects. To ex
Externí odkaz:
https://doaj.org/article/fa8bf5650b3a4210b814093e546e0749
Autor:
Kyle R. Jenks, Jason D. Shepherd
Publikováno v:
Cell Reports, Vol 30, Iss 6, Pp 1982-1994.e4 (2020)
Summary: The development of neuronal circuits requires both hard-wired gene expression and experience-dependent plasticity. Sensory processing, such as binocular vision, is especially sensitive to perturbations of experience. We investigated the expe
Externí odkaz:
https://doaj.org/article/e323c673f3e34d0dbbc554ce39bee27b
Autor:
Elissa D. Pastuzyn, Jason D. Shepherd
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 10 (2017)
Angelman syndrome (AS) is a neurodevelopmental disorder that results from deletions or mutations in chromosome 15, which usually includes the UBE3A gene. Ube3A protein is an E3 ubiquitin ligase that ubiquitinates proteins and targets them for degrada
Externí odkaz:
https://doaj.org/article/76db2324fbc4424688413ddb4cf5f05b
Autor:
D Garrett Brown, Raymond Soto, Soumya Yandamuri, Colleen Stone, Laura Dickey, Joao Carlos Gomes-Neto, Elissa D Pastuzyn, Rickesha Bell, Charisse Petersen, Kaitlin Buhrke, Robert S Fujinami, Ryan M O'Connell, W Zac Stephens, Jason D Shepherd, Thomas E Lane, June L Round
Publikováno v:
eLife, Vol 8 (2019)
Symbiotic microbes impact the function and development of the central nervous system (CNS); however, little is known about the contribution of the microbiota during viral-induced neurologic damage. We identify that commensals aid in host defense foll
Externí odkaz:
https://doaj.org/article/8f9c877ea32349559ba7e12f43882bd9
Autor:
Junjie Xu, Simon Erlendsson, Manvendra Singh, Matthew Regier, Iosune Ibiricu, Gregory S. Day, Amanda L. Piquet, Stacey L. Clardy, Cedric Feschotte, John A. G. Briggs, Jason D. Shepherd
Publikováno v:
bioRxiv
Theparaneoplastic Ma antigen(PNMA) genes are associated with cancer-induced paraneoplastic syndromes that present with neurological symptoms and autoantibody production. How PNMA proteins trigger a severe autoimmune disease is unclear.PNMAgenes are p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::493fe0a65a242c127cd89b91c1fe570a
https://europepmc.org/articles/PMC9934673/
https://europepmc.org/articles/PMC9934673/
Autor:
Donghwi, Bae, Rachel Elizabeth, Jones, Katherine M, Piscopo, Mitali, Tyagi, Jason D, Shepherd, Julie, Hollien
Publikováno v:
Molecular biology of the cell. 33(13)
Huntington's disease is characterized by accumulation of the aggregation-prone mutant Huntingtin (mHTT) protein. Here, we show that expression of exon 1 of mHTT in mouse cultured cells activates IRE1, the transmembrane sensor of stress in the endopla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::82186a4b8dc43612ea52a471f2f6212c
https://pubmed.ncbi.nlm.nih.gov/36044348
https://pubmed.ncbi.nlm.nih.gov/36044348
Autor:
Donghwi Bae, Rachel Elizabeth Jones, Katherine M. Piscopo, Mitali Tyagi, Jason D. Shepherd, Julie Hollien
Publikováno v:
Molecular Biology of the Cell. 33
Huntington’s disease is characterized by accumulation of the aggregation-prone mutant Huntingtin (mHTT) protein. Here, we show that expression of mHTT in mouse cultured cells activates IRE1, the transmembrane sensor of stress in the endoplasmic ret
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bf99904f481fe87337ea2b9961b1724
https://doi.org/10.1091/mbc.e22-07-0281
https://doi.org/10.1091/mbc.e22-07-0281
Autor:
Pradipta R. Ray, Tarjani Shukla, June Bryan de la Peña, Jason D. Shepherd, Sarah Loerch, Lokesh Basavarajappa, Paulino Barragán-Iglesias, Salim Megat, Jane Song, Zachary T. Campbell, Nikesh Kunder, Andi Wanghzou, Kenneth Hoyt, Dominique James, Jamie K. Moy, Theodore J. Price, Oswald Steward, Tzu-Fang Lou
Publikováno v:
J Neurosci
Injury responses require communication between different cell types in the skin. Sensory neurons contribute to inflammation and can secrete signaling molecules that affect non-neuronal cells. Despite the pervasive role of translational regulation in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00169068d62eead004bb8fb082a82546
https://doi.org/10.1523/jneurosci.0440-21.2021
https://doi.org/10.1523/jneurosci.0440-21.2021
Autor:
Alicia Ravens, Cornelia N. Stacher-Hörndli, Jared Emery, Susan Steinwand, Jason D. Shepherd, Christopher Gregg
Foraging involves innate decision heuristics that are adapted for the wild but can cause economically suboptimal cognitive biases in some contexts. The mechanisms underlying cognitive biases are poorly understood but are likely genetic. Here, we inve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19fc24ae368a071e5221d10516f9a81b
https://doi.org/10.1101/2022.07.27.501779
https://doi.org/10.1101/2022.07.27.501779
Publikováno v:
Trends Neurosci
Viruses and transposable elements are major drivers of evolution and make up over half the sequences in the human genome. In some cases, these elements are co-opted to perform biological functions for the host. Recent studies made the surprising obse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0519a8485658b97ad779b3678cb9a4c
https://doi.org/10.1016/j.tins.2020.12.003
https://doi.org/10.1016/j.tins.2020.12.003