Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Jason D. Meadows"'
Autor:
Jason D. Meadows, Joseph A. Breuer, Shanna N. Lavalle, Michael R. Hirschenberger, Meera M. Patel, Duong Nguyen, Alyssa Kim, Jessica Cassin, Michael R. Gorman, David K. Welsh, Pamela L. Mellon, Hanne M. Hoffmann
Publikováno v:
Molecular Metabolism, Vol 57, Iss , Pp 101431- (2022)
Objective: The increasing prevalence of obesity makes it important to increase the understanding of the maturation and function of the neuronal integrators and regulators of metabolic function. Methods: Behavioral, molecular, and physiological analys
Externí odkaz:
https://doaj.org/article/600c4c304fde4903a956dadec4508da6
Autor:
Michael R. Gorman, Jeffrey W. Doser, Joseph A Breuer, Jessica Sora Lee, David K. Welsh, Austin Y Chin, Duong Nguyen, Hanne M. Hoffmann, Jason D. Meadows, Alexandra M. Yaw, Haley J Oosterhouse, Pamela L. Mellon, Karen J. Tonsfeldt, Crystal Trang, Brooke M Devries
Publikováno v:
J Neurosci Res
The homeodomain transcription factors sine oculis homeobox 3 (Six3) and ventral anterior homeobox 1 (Vax1) are required for brain development. Their expression in specific brain areas is maintained in adulthood, where their functions are poorly under
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c52bb9e5eff9d33a767b57665168b3f1
https://pubmed.ncbi.nlm.nih.gov/34212416
https://pubmed.ncbi.nlm.nih.gov/34212416
Kisspeptin Regulates Gonadotropin Genes via Immediate Early Gene Induction in Pituitary Gonadotropes
Autor:
Emily A. Witham, Alexander S. Kauffman, Pamela L. Mellon, Hanne M. Hoffmann, Djurdjica Coss, Jason D. Meadows, Shadi Shojaei
Publikováno v:
Molecular Endocrinology. 27:1283-1294
Kisspeptin signaling through its receptor, Kiss1R, is crucial for many reproductive functions including puberty, sex steroid feedback, and overall fertility. Although the importance of Kiss1R in the brain is firmly established, its role in regulating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa1bb53e3332dd9dcf2d4635b7dfa65b
https://doi.org/10.1210/me.2012-1405
https://doi.org/10.1210/me.2012-1405
Autor:
Pamela L. Mellon, Daniel D. Clark, Michael R. Gorman, Jason D. Meadows, Megumi Hatori, Satchidananda Panda
Publikováno v:
Journal of Biological Rhythms. 28:15-25
The suprachiasmatic nucleus (SCN) of the mammalian hypothalamus is the central pacemaker for peripheral and organismal circadian rhythms. The development of this hypothalamic structure depends on genetic programs throughout embryogenesis. We have inv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1b4606dd4e6bf0bde59e894e934f7c9
https://doi.org/10.1177/0748730412468084
https://doi.org/10.1177/0748730412468084
Publikováno v:
Endocrinology. 153:4522-4532
Sex steroid hormone production and feedback mechanisms are critical components of the hypothalamic-pituitary-gonadal (HPG) axis and regulate fetal development, puberty, fertility, and menopause. In female mammals, developmental exposure to excess and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::741b91eb68684d07b0667809c8b41ab3
https://doi.org/10.1210/en.2012-1283
https://doi.org/10.1210/en.2012-1283
Roles of binding elements, FOXL2 domains, and interactions with cJUN and SMADs in regulation of FSHβ
Autor:
Nermeen H. Barakat, Patricia Pepa, Kellie M Breen, Arpi Hambarchyan, Jason D. Meadows, Pamela L. Mellon, Djurdjica Coss, Lacey L. Roybal
Publikováno v:
Molecular endocrinology (Baltimore, Md.), vol 28, iss 10
We previously identified FOXL2 as a critical component in FSHβ gene transcription. Here, we show that mice deficient in FOXL2 have lower levels of gonadotropin gene expression and fewer LH- and FSH-containing cells, but the same level of other pitui
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef1db9ff6e36e10eb7edb0c88ecaf871
https://escholarship.org/uc/item/7x32m7dc
https://escholarship.org/uc/item/7x32m7dc
Autor:
Susan L. Mayo, Pamela L. Mellon, Daniel D. Clark, Jason D. Meadows, Ikuo Kimura, Rachel Larder
Together, the hypothalamus, pituitary and gonads direct the development and regulation of reproductive function in mammals. Gonadotropin-releasing hormone (GnRH) expression is limited to ∼800 neurons that originate in the olfactory placode then mig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47adafcdc1b15a71c39535250c37d9bb
https://europepmc.org/articles/PMC3771655/
https://europepmc.org/articles/PMC3771655/
Autor:
Pamela L. Mellon, Anita K. Iyer, Paul P. Shao, Christine A. Glidewell-Kenney, Anna M. H. Grove, Jason D. Meadows
Publikováno v:
Molecular endocrinology (Baltimore, Md.). 27(3)
Genetic studies in human patients with idiopathic hypogonadotropic hypogonadism (IHH) identified mutations in the genes that encode neurokinin B (NKB) and the neurokinin 3 receptor (NK3R). However, determining the mechanism whereby NKB regulates gona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2437ce6a7c599f172f43219f90de3bf
https://pubmed.ncbi.nlm.nih.gov/23393128
https://pubmed.ncbi.nlm.nih.gov/23393128
Multiple homeodomain transcription factors are crucial for pituitary organogenesis and cellular differentiation. A homeodomain repressor, Msx1, is expressed from the ventral aspect of the developing anterior pituitary and implicated in gonadotrope di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4444811028e4846b0dc8e8e6447bdc0
https://europepmc.org/articles/PMC3589667/
https://europepmc.org/articles/PMC3589667/