Zobrazeno 1 - 10
of 133
pro vyhledávání: '"Jason D. Lieb"'
Autor:
Vincent J. Lynch, Mauris C. Nnamani, Aurélie Kapusta, Kathryn Brayer, Silvia L. Plaza, Erik C. Mazur, Deena Emera, Shehzad Z. Sheikh, Frank Grützner, Stefan Bauersachs, Alexander Graf, Steven L. Young, Jason D. Lieb, Francesco J. DeMayo, Cédric Feschotte, Günter P. Wagner
Publikováno v:
Cell Reports, Vol 10, Iss 4, Pp 551-561 (2015)
A major challenge in biology is determining how evolutionarily novel characters originate; however, mechanistic explanations for the origin of new characters are almost completely unknown. The evolution of pregnancy is an excellent system in which to
Externí odkaz:
https://doaj.org/article/160dd80e03d34e2d89920f43dc99d149
Publikováno v:
PLoS Genetics, Vol 11, Iss 4, p e1005117 (2015)
After fertilization but prior to the onset of zygotic transcription, the C. elegans zygote cleaves asymmetrically to create the anterior AB and posterior P1 blastomeres, each of which goes on to generate distinct cell lineages. To understand how patt
Externí odkaz:
https://doaj.org/article/f3935849659c40a3ada137d6bf3159ce
Autor:
Zhihao Ding, Yunyun Ni, Sander W Timmer, Bum-Kyu Lee, Anna Battenhouse, Sandra Louzada, Fengtang Yang, Ian Dunham, Gregory E Crawford, Jason D Lieb, Richard Durbin, Vishwanath R Iyer, Ewan Birney
Publikováno v:
PLoS Genetics, Vol 11, Iss 4, p e1005177 (2015)
[This corrects the article DOI: 10.1371/journal.pgen.1004798.].
Externí odkaz:
https://doaj.org/article/83e971f382564f24903663e69bd1e39f
Autor:
Zhihao Ding, Yunyun Ni, Sander W Timmer, Bum-Kyu Lee, Anna Battenhouse, Sandra Louzada, Fengtang Yang, Ian Dunham, Gregory E Crawford, Jason D Lieb, Richard Durbin, Vishwanath R Iyer, Ewan Birney
Publikováno v:
PLoS Genetics, Vol 10, Iss 11, p e1004798 (2014)
Associating genetic variation with quantitative measures of gene regulation offers a way to bridge the gap between genotype and complex phenotypes. In order to identify quantitative trait loci (QTLs) that influence the binding of a transcription fact
Externí odkaz:
https://doaj.org/article/d650d1d5787144e6b909d9a7af586c3a
Autor:
Sunny Yang Liu, Natalia Ayres, Alexis V. Stutzman, Omar Almakki, Jason D. Lieb, Sachie Ikegami, Kohta Ikegami, Stefano Secchia, Ivan P. Moskowitz
Publikováno v:
Circulation Research. 127
The segregation of heterochromatin domains (LADs) at the nuclear periphery by the nuclear lamina, composed by polymerized nuclear Lamin A/C, provides a longstanding paradigm for the control of gene expression and for the mechanisms underlying Lamin-A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cdebf16a7bbcb8032d33ba483795ce23
https://doi.org/10.1161/res.127.suppl_1.508
https://doi.org/10.1161/res.127.suppl_1.508
Publikováno v:
Dev Cell
LMNA encodes nuclear lamin A/C that tethers lamina-associated heterochromatin domains (LADs) to the nuclear periphery. Point mutations in LMNA cause degenerative disorders including the premature aging disorder Hutchinson-Gilford progeria, but the me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62bc3a692936e97532b363ab8d8729be
https://europepmc.org/articles/PMC7201903/
https://europepmc.org/articles/PMC7201903/
Autor:
Anne Vielle, Jackie Lang, Yan Dong, Sevinc Ercan, Chitra Kotwaliwale, Andreas Rechtsteiner, Alex Appert, Q Brent Chen, Andrea Dose, Thea Egelhofer, Hiroshi Kimura, Przemyslaw Stempor, Abby Dernburg, Jason D Lieb, Susan Strome, Julie Ahringer
Publikováno v:
PLoS Genetics, Vol 8, Iss 9, p e1002933 (2012)
The Caenorhabditis elegans dosage compensation complex (DCC) equalizes X-chromosome gene dosage between XO males and XX hermaphrodites by two-fold repression of X-linked gene expression in hermaphrodites. The DCC localizes to the X chromosomes in her
Externí odkaz:
https://doaj.org/article/f43f8cf7e6aa42c480ecd8b77d089361
Autor:
Andrea J Gossett, Jason D Lieb
Publikováno v:
PLoS Genetics, Vol 8, Iss 6, p e1002771 (2012)
Previous studies in Saccharomyces cerevisiae established that depletion of histone H4 results in the genome-wide transcriptional de-repression of hundreds of genes. To probe the mechanism of this transcriptional de-repression, we depleted nucleosomes
Externí odkaz:
https://doaj.org/article/a5f626306b6e48c8b1d141626f7aaef1
Autor:
Ivan Rusyn, Terrence S. Furey, Grace A. Chappell, Jeremy M. Simon, Gregory E. Crawford, Paul A Cotney, Lauren Lewis, Wanda Bodnar, Sebastian Pott, Jason D. Lieb, Jennifer W Israel, Alexias Safi, Hala Boulos
Publikováno v:
Mammalian Genome. 29:153-167
Epigenetic effects of environmental chemicals are under intense investigation to fill existing knowledge gaps between environmental/occupational exposures and adverse health outcomes. Chromatin accessibility is one prominent mechanism of epigenetic c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cb980b70582af44fcdba7aae93e73bf
https://doi.org/10.1007/s00335-018-9739-6
https://doi.org/10.1007/s00335-018-9739-6
Autor:
Andres R Mansisidor, Germano Cecere, Sebastian Hoersch, Morten B Jensen, Trupti Kawli, Lisa M Kennedy, Violeta Chavez, Man-Wah Tan, Jason D Lieb, Alla Grishok
Publikováno v:
PLoS Genetics, Vol 7, Iss 9, p e1002299 (2011)
Insulin signaling has a profound effect on longevity and the oxidative stress resistance of animals. Inhibition of insulin signaling results in the activation of DAF-16/FOXO and SKN-1/Nrf transcription factors and increased animal fitness. By studyin
Externí odkaz:
https://doaj.org/article/952a7a01c6164bd3a0e7659bb4b9b77f