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pro vyhledávání: '"Jason D. Dapper"'
Publikováno v:
Neurobiology of Disease, Vol 59, Iss , Pp 26-37 (2013)
The p38 mitogen-activated protein kinase (MAPK) isoforms are phosphorylated by a variety of stress stimuli in neurodegenerative disease and act as upstream activators of myriad pathogenic processes. Thus, p38 MAPK inhibitors are of growing interest a
Externí odkaz:
https://doaj.org/article/c67db30c1edb4d468f5242b7a776932d
Publikováno v:
Neurobiology of Disease, Vol 59, Iss, Pp 26-37 (2013)
The p38 mitogen-activated protein kinase (MAPK) isoforms are phosphorylated by a variety of stress stimuli in neurodegenerative disease and act as upstream activators of myriad pathogenic processes. Thus, p38 MAPK inhibitors are of growing interest a
Publikováno v:
Mammalian Genome. 16:672-682
The mutant allelic series of the mouse quaking gene consists of the spontaneous quaking(viable) (qk(v)) allele, which is homozygous viable with a dysmyelination phenotype, and four ENU-induced alleles (qk(kt 1), qk(k2), qk(kt3/4), and qk(l-1)), which
Autor:
Marjorie Withers, Jason D. Dapper, Keiko Wakui, James R. Lupski, Christine J. Shaw, Lisa G. Shaffer, Leah I. Elizondo, Pawel Stankiewicz, Sung Sup Park
Publikováno v:
The American Journal of Human Genetics. 72(5):1101-1116
To investigate the potential involvement of genome architecture in nonrecurrent chromosome rearrangements, we analyzed the breakpoints of eight translocations and 18 unusual-sized deletions involving human proximal 17p. Surprisingly, we found that ma
Autor:
Samuel D. Crish, Jason D. Dapper, Wendi S. Lambert, Tatiana N. Sidorova, Pooja Balaram, Sarah E. MacNamee, David J. Calkins
Publikováno v:
Neuroscience. 229
Failure of anterograde transport to distal targets in the brain is a common feature of neurodegenerative diseases. We have demonstrated in rodent models of glaucoma, the most common optic neuropathy, early loss of anterograde transport along the reti
Autor:
Jason D. Dapper, Monica J. Justice
Publikováno v:
Movement disorders : official journal of the Movement Disorder Society. 20(10)
The quakingviable (qkv) mutant mouse shows a recessive neurological phenotype that includes central nervous system (CNS) dysmyelination, seizures, and tremor associated with voluntary movement. The molecular defect of qkv has been previously reported