Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Jason D Wells"'
Publikováno v:
Cancer Informatics, Vol 20 (2021)
Motivation: Despite increasing understanding of the molecular characteristics of cancer, chemotherapy success rates remain low for many cancer types. Studies have attempted to identify patient and tumor characteristics that predict sensitivity or res
Externí odkaz:
https://doaj.org/article/02adf09781d74dfb95d30f31d2f24da8
Publikováno v:
PLoS ONE, Vol 14, Iss 11, p e0224267 (2019)
BackgroundPrecision oncology seeks to integrate multiple layers of data from a patient's cancer to effectively tailor therapy. Conventional chemotherapies are sometimes effective but accompanied by adverse events, warranting the identification of a b
Externí odkaz:
https://doaj.org/article/481fc2af96824e0a9f5f1c8e2d19830e
Autor:
Todd W. Miller, Matthew P. Goetz, Chao Cheng, Arminja N. Kettenbach, Eugene Demidenko, Judy C. Boughey, Jia Yu, Krishna R. Kalari, Liewei Wang, Megan A. Zeldenrust, Stephanie C. Liu, Wei Yang, Nicole A. Traphagen, Riley A. Hampsch, Matthew Ung, Jason D. Wells, Kevin Shee
Suppl Data and Methods Fig. S1. Flowchart of experimental approach. Fig. S2. Unsupervised hierarchical clustering of breast or ovarian cancer cell lines confirms known subtypes. Fig. S3. Validation of BR/OV-1 and -2 clusters of BRCA and OVCA cell lin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1575eb5671b3a3ee12b9fd52e46d41ac
https://doi.org/10.1158/1078-0432.22473524.v1
https://doi.org/10.1158/1078-0432.22473524.v1
Autor:
Todd W. Miller, William B. Kinlaw, Abigail E. Goen, Jonathan D. Marotti, Yina H. Huang, Eugene Demidenko, Lionel D. Lewis, Darcy B. Pooler, Lloye M. Dillon, Kevin Shee, Jennifer L. Fields, Charlotte F. McCleery, Nicole A. Traphagen, Jason D. Wells, Riley A. Hampsch
Table S1 shows normalized mRNA counts from NanoString analysis of MCF-7 xenografts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::034af3ee8adf3492f1c3bc3cb7b1f82f
https://doi.org/10.1158/1078-0432.22474875.v1
https://doi.org/10.1158/1078-0432.22474875.v1
Autor:
Todd W. Miller, William B. Kinlaw, Abigail E. Goen, Jonathan D. Marotti, Yina H. Huang, Eugene Demidenko, Lionel D. Lewis, Darcy B. Pooler, Lloye M. Dillon, Kevin Shee, Jennifer L. Fields, Charlotte F. McCleery, Nicole A. Traphagen, Jason D. Wells, Riley A. Hampsch
Purpose:Despite adjuvant endocrine therapy for patients with estrogen receptor alpha (ER)-positive breast cancer, dormant residual disease can persist for years and eventually cause tumor recurrence. We sought to deduce mechanisms underlying the pers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04a8c9c2f0753d34d218ff789fb6a458
https://doi.org/10.1158/1078-0432.c.6528927.v1
https://doi.org/10.1158/1078-0432.c.6528927.v1
Autor:
Todd W. Miller, William B. Kinlaw, Abigail E. Goen, Jonathan D. Marotti, Yina H. Huang, Eugene Demidenko, Lionel D. Lewis, Darcy B. Pooler, Lloye M. Dillon, Kevin Shee, Jennifer L. Fields, Charlotte F. McCleery, Nicole A. Traphagen, Jason D. Wells, Riley A. Hampsch
Legend for Table S1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::265e56648460b9d5940d40c5fb956f3e
https://doi.org/10.1158/1078-0432.22474884.v1
https://doi.org/10.1158/1078-0432.22474884.v1
Autor:
Todd W. Miller, Matthew P. Goetz, Chao Cheng, Arminja N. Kettenbach, Eugene Demidenko, Judy C. Boughey, Jia Yu, Krishna R. Kalari, Liewei Wang, Megan A. Zeldenrust, Stephanie C. Liu, Wei Yang, Nicole A. Traphagen, Riley A. Hampsch, Matthew Ung, Jason D. Wells, Kevin Shee
Purpose:We hypothesized that integrated analysis of cancer types from different lineages would reveal novel molecularly defined subgroups with unique therapeutic vulnerabilities. On the basis of the molecular similarities between subgroups of breast
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b752bad97ad5ee76460a8cb0a9016bd
https://doi.org/10.1158/1078-0432.c.6528530
https://doi.org/10.1158/1078-0432.c.6528530
Autor:
Todd W. Miller, Matthew P. Goetz, Chao Cheng, Arminja N. Kettenbach, Eugene Demidenko, Judy C. Boughey, Jia Yu, Krishna R. Kalari, Liewei Wang, Megan A. Zeldenrust, Stephanie C. Liu, Wei Yang, Nicole A. Traphagen, Riley A. Hampsch, Matthew Ung, Jason D. Wells, Kevin Shee
Table S1. BRCA and OVCA cell lines analyzed. Cell line data were obtained from the GDSC or CCLE databases as indicated. Table S2. Drug sensitivity analysis for BR/OV-1 vs. -2 cell lines in GDSC. Table S3. BR/OV-1/2 gene expression classifier. Table S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c5b5f9424accae72b44d6464f2d4e17
https://doi.org/10.1158/1078-0432.22473521.v1
https://doi.org/10.1158/1078-0432.22473521.v1
Autor:
Todd W. Miller, William B. Kinlaw, Abigail E. Goen, Jonathan D. Marotti, Yina H. Huang, Eugene Demidenko, Lionel D. Lewis, Darcy B. Pooler, Lloye M. Dillon, Kevin Shee, Jennifer L. Fields, Charlotte F. McCleery, Nicole A. Traphagen, Jason D. Wells, Riley A. Hampsch
Fig. S1 shows that dormant ER+ breast cancer cells retain tumor-initiating capacity. Fig. S2 shows individual tumor growth curves. Fig. S3 shows IHC images for Ki67, cleaved caspase-3 and ER in xenografts. Fig. S4 shows Gene Set Variation Analysis of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::942f4cb45c16679917f436a94aadf17d
https://doi.org/10.1158/1078-0432.22474878
https://doi.org/10.1158/1078-0432.22474878
Autor:
Todd W. Miller, William B. Kinlaw, Abigail E. Goen, Jonathan D. Marotti, Yina H. Huang, Eugene Demidenko, Lionel D. Lewis, Darcy B. Pooler, Lloye M. Dillon, Kevin Shee, Jennifer L. Fields, Charlotte F. McCleery, Nicole A. Traphagen, Jason D. Wells, Riley A. Hampsch
Supplementary methods and supplementary references cited.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::954554b359aa65290b345ea8d91cbc8b
https://doi.org/10.1158/1078-0432.22474881.v1
https://doi.org/10.1158/1078-0432.22474881.v1