Zobrazeno 1 - 10
of 115
pro vyhledávání: '"Jason D Weber"'
Publikováno v:
eLife, Vol 8 (2019)
Proliferating cells often have increased glucose consumption and lactate excretion relative to the same cells in the quiescent state, a phenomenon known as the Warburg effect. Despite an increase in glycolysis, however, here we show that non-transfor
Externí odkaz:
https://doaj.org/article/e65f61cec7b345d382006736cb79f515
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e42005 (2012)
Osteoclasts are terminally differentiated cells that attach to bone and secrete proteases to degrade the bone matrix. The primary protease responsible for the degradation of the organic component of the bone matrix is Cathepsin K, which was largely t
Externí odkaz:
https://doaj.org/article/7855893af56740ffb4f0446e434de3eb
Autor:
Daniel A Rauch, Michelle A Hurchla, John C Harding, Hongju Deng, Lauren K Shea, Mark C Eagleton, Stefan Niewiesk, Michael D Lairmore, David Piwnica-Worms, Thomas J Rosol, Jason D Weber, Lee Ratner, Katherine N Weilbaecher
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e15755 (2010)
The ARF tumor suppressor regulates p53 as well as basic developmental processes independent of p53, including osteoclast activation, by controlling ribosomal biogenesis. Here we provide evidence that ARF is a master regulator of bone remodeling and o
Externí odkaz:
https://doaj.org/article/9e04b58e081040a1b178b0f2155d2a9b
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Abstract Tumor cells require nominal increases in protein synthesis in order to maintain high proliferation rates. As such, tumor cells must acquire enhanced ribosome production. How the numerous mutations in tumor cells ultimately achieve this aberr
Externí odkaz:
https://doaj.org/article/60e397c48e944433a97436aa66b949cd
Autor:
Che-Pei Kung, Jason D. Weber
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Anti-tumorigenic mechanisms mediated by the tumor suppressor p53, upon oncogenic stresses, are our bodies’ greatest weapons to battle against cancer onset and development. Consequently, factors that possess significant p53-regulating activities hav
Externí odkaz:
https://doaj.org/article/601d69ae18234fac8f2b99d42deb97ff
Publikováno v:
Breast Cancer Research, Vol 21, Iss 1, Pp 1-7 (2019)
Abstract Background Lobular carcinoma in situ (LCIS) of the breast is a risk factor of developing invasive breast cancer. We evaluated the racial differences in the risks of subsequent invasive breast cancer following LCIS. Methods We utilized data f
Externí odkaz:
https://doaj.org/article/9c59dc88c0814eb89db24e8e0b8eecef
Autor:
Alex H. Wagner, Siddhartha Devarakonda, Zachary L. Skidmore, Kilannin Krysiak, Avinash Ramu, Lee Trani, Jason Kunisaki, Ashiq Masood, Saiama N. Waqar, Nicholas C. Spies, Daniel Morgensztern, Jason Waligorski, Jennifer Ponce, Robert S. Fulton, Leonard B. Maggi, Jason D. Weber, Mark A. Watson, Christopher J. O’Conor, Jon H. Ritter, Rachelle R. Olsen, Haixia Cheng, Anandaroop Mukhopadhyay, Ismail Can, Melissa H. Cessna, Trudy G. Oliver, Elaine R. Mardis, Richard K. Wilson, Malachi Griffith, Obi L. Griffith, Ramaswamy Govindan
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Small cell lung cancer (SCLC) patients frequently relapse and become resistant to chemotherapy. Here, the authors analyse the genomic and transcriptomic landscape of primary and relapsed SCLC patients as well as in vitro models, and discover that act
Externí odkaz:
https://doaj.org/article/633460ab94c74c7ba9529694b90819e7
Autor:
Loren S. Michel, Christine H. Chung, Jason D. Weber, Jeffrey M. Arbeit, Raleigh D. Kladney, James Lewis, Peter Humphrey, Ryan Day, Yiyu Dong, Aimin Li, Dorota Grabowska, Kaihua Zhang, Jianbo Wang
PDF file - 264K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cce78bbe92d3d54962c63e851f0ba28
https://doi.org/10.1158/1541-7786.22519048
https://doi.org/10.1158/1541-7786.22519048
Autor:
Loren S. Michel, Christine H. Chung, Jason D. Weber, Jeffrey M. Arbeit, Raleigh D. Kladney, James Lewis, Peter Humphrey, Ryan Day, Yiyu Dong, Aimin Li, Dorota Grabowska, Kaihua Zhang, Jianbo Wang
Trop2, an oncogenic cell surface protein under investigation as a therapeutic target, is commonly overexpressed in several epithelial tumor types yet its function in tumor biology remains relatively unexplored. To investigate the role of Trop2 in epi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1044bfb33d2227e1ae9b0a320941d42d
https://doi.org/10.1158/1541-7786.c.6542266
https://doi.org/10.1158/1541-7786.c.6542266
Supplementary Figure Legends 1-4 from Synthetic Lethality through Combined Notch–Epidermal Growth Factor Receptor Pathway Inhibition in Basal-Like Breast Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e4c2e6eb611626589a7d68512fde14b
https://doi.org/10.1158/0008-5472.22382112.v1
https://doi.org/10.1158/0008-5472.22382112.v1