Zobrazeno 1 - 10
of 459
pro vyhledávání: '"Jason D Warren"'
Autor:
Jason D Warren, Anna Volkmer, Chris JD Hardy, David A Copland, Sarah J Wallace, Maya L Henry, Rosemary Varley
Publikováno v:
BMJ Open, Vol 14, Iss 5 (2024)
Introduction The term primary progressive aphasia (PPA) describes a group of language-led dementias. Disease-modifying treatments that delay, slow or reverse progression of PPA are currently lacking, though a number of interventions to manage the sym
Externí odkaz:
https://doaj.org/article/1ecc19a7cf374ae09b263cc3d555012b
Autor:
Jason D Warren, Jonathan D Rohrer, Caroline Greaves, Lucianne Dobson, Rebecca L Bond, Chris JD Hardy, Sebastian J Crutch, Jessica Jiang, Elia Benhamou, Mai-Carmen Requena-Komuro, Suzie Barker, Lucy Russell, Emilie V Brotherhood
Publikováno v:
BMJ Open, Vol 12, Iss 11 (2022)
Objectives We explored whether adapting neuropsychological tests for online administration during the COVID-19 pandemic was feasible for dementia research.Design We used a longitudinal design for healthy controls, who completed face-to-face assessmen
Externí odkaz:
https://doaj.org/article/ef7dd2b33cb64c79a824d652821af8ce
Autor:
Alexandra L Young, Razvan V Marinescu, Neil P Oxtoby, Martina Bocchetta, Keir Yong, Nicholas C Firth, David M Cash, David L Thomas, Katrina M Dick, Jorge Cardoso, John van Swieten, Barbara Borroni, Daniela Galimberti, Mario Masellis, Maria Carmela Tartaglia, James B Rowe, Caroline Graff, Fabrizio Tagliavini, Giovanni B Frisoni, Robert Laforce, Elizabeth Finger, Alexandre de Mendonça, Sandro Sorbi, Jason D Warren, Sebastian Crutch, Nick C Fox, Sebastien Ourselin, Jonathan M Schott, Jonathan D Rohrer, Daniel C Alexander, The Genetic FTD Initiative (GENFI), The Alzheimer’s Disease Neuroimaging Initiative (ADNI)
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Progressive diseases tend to be heterogeneous in their underlying aetiology mechanism, disease manifestation, and disease time course. Here, Young and colleagues devise a computational method to account for both phenotypic heterogeneity and temporal
Externí odkaz:
https://doaj.org/article/edb6d5c8fa064af8b4704e322938446c
Publikováno v:
Pilot and Feasibility Studies, Vol 4, Iss 1, Pp 1-10 (2018)
Abstract Background Primary progressive aphasia is a language-led dementia, often associated with frontotemporal dementia. It presents as insidious deterioration of language skills (e.g. naming objects and understanding complex sentences), with relat
Externí odkaz:
https://doaj.org/article/89cb7b5c229e4b37ab7568f394bdbee1
Publikováno v:
PLoS ONE, Vol 13, Iss 2, p e0192518 (2018)
Pathogenic protein accumulation and spread are fundamental principles of neurodegenerative diseases and ultimately account for the atrophy patterns that distinguish these diseases clinically. However, the biological mechanisms that link pathogenic pr
Externí odkaz:
https://doaj.org/article/e19919b1a9db4c029d6e5d5db808d878
Autor:
Anthipa Chokesuwattanaskul, Dexter Penn, Claudia Albero, Jeremy C. S. Johnson, Elia Benhamou, Lucy L. Russell, Chris J. D. Hardy, Charles R. Marshall, Jonathan D. Rohrer, Jason D. Warren
Publikováno v:
Frontiers in Neurology, Vol 15 (2024)
BackgroundInappropriate trusting behaviour may have significant social, financial and other consequences for people living with dementia. However, its clinical associations and predictors have not been clarified. Here we addressed this issue in canon
Externí odkaz:
https://doaj.org/article/99e988f291e844f485a03e1632884cab
Autor:
Rebecca Louise Bond, Laura E Downey, Philip SJ Weston, Catherine F Slattery, Camilla N Clark, Kirsty eMacpherson, Catherine J Mummery, Jason D Warren
Publikováno v:
Frontiers in Human Neuroscience, Vol 10 (2016)
Despite considerable evidence for abnormalities of self-awareness in Alzheimer’s disease (AD), the cognitive mechanisms of altered self-processing in AD have not been fully defined. Here we addressed this issue in a detailed analysis of self/non-se
Externí odkaz:
https://doaj.org/article/748cc684ed5846d0b5270a76c5455e78
Publikováno v:
PLoS ONE, Vol 3, Iss 1, p e1470 (2008)
Pitch patterns, such as melodies, consist of two levels of structure: a global level, comprising the pattern of ups and downs, or contour; and a local level, comprising the precise intervals that make up this contour. An influential neuropsychologica
Externí odkaz:
https://doaj.org/article/66f6626f85fe4ad1a944789d683dbb18
Autor:
Tobias Overath, Rhodri Cusack, Sukhbinder Kumar, Katharina von Kriegstein, Jason D Warren, Manon Grube, Robert P Carlyon, Timothy D Griffiths
Publikováno v:
PLoS Biology, Vol 5, Iss 11, p e288 (2007)
The entropy metric derived from information theory provides a means to quantify the amount of information transmitted in acoustic streams like speech or music. By systematically varying the entropy of pitch sequences, we sought brain areas where neur
Externí odkaz:
https://doaj.org/article/b5d39061df104490afe1dfcb477f61d1
Publikováno v:
PLoS Computational Biology, Vol 3, Iss 6, p e100 (2007)
This work examines the computational architecture used by the brain during the analysis of the spectral envelope of sounds, an important acoustic feature for defining auditory objects. Dynamic causal modelling and Bayesian model selection were used t
Externí odkaz:
https://doaj.org/article/018fc9523267415080f8ee5f8c87a3e4